no code implementations • 12 Jun 2023 • Bongjin Koo, Julien Martel, Ariana Peck, Axel Levy, Frédéric Poitevin, Nina Miolane
Cryogenic electron microscopy (cryo-EM) has transformed structural biology by allowing to reconstruct 3D biomolecular structures up to near-atomic resolution.
no code implementations • 29 Sep 2022 • Youssef Nashed, Ariana Peck, Julien Martel, Axel Levy, Bongjin Koo, Gordon Wetzstein, Nina Miolane, Daniel Ratner, Frédéric Poitevin
Cryogenic electron microscopy (cryo-EM) provides a unique opportunity to study the structural heterogeneity of biomolecules.
1 code implementation • 15 Mar 2022 • Axel Levy, Frédéric Poitevin, Julien Martel, Youssef Nashed, Ariana Peck, Nina Miolane, Daniel Ratner, Mike Dunne, Gordon Wetzstein
We introduce cryoAI, an ab initio reconstruction algorithm for homogeneous conformations that uses direct gradient-based optimization of particle poses and the electron scattering potential from single-particle cryo-EM data.