Search Results for author: ChangYu Hsieh

Found 2 papers, 1 papers with code

ODBO: Bayesian Optimization with Search Space Prescreening for Directed Protein Evolution

2 code implementations19 May 2022 Lixue Cheng, ZiYi Yang, ChangYu Hsieh, Benben Liao, Shengyu Zhang

Directed evolution is a versatile technique in protein engineering that mimics the process of natural selection by iteratively alternating between mutagenesis and screening in order to search for sequences that optimize a given property of interest, such as catalytic activity and binding affinity to a specified target.

Bayesian Optimization Experimental Design +1

SPLDExtraTrees: Robust machine learning approach for predicting kinase inhibitor resistance

no code implementations15 Nov 2021 ZiYi Yang, Zhaofeng Ye, Yijia Xiao, ChangYu Hsieh, Shengyu Zhang

Drug resistance is a major threat to the global health and a significant concern throughout the clinical treatment of diseases and drug development.

BIG-bench Machine Learning

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