Index analysis: an approach to understand signal transduction with application to the EGFR signalling pathway

no code implementations • 17 Feb 2023 • Jane Knöchel, Charlotte Kloft, Wilhelm Huisinga

In systems biology and pharmacology, large-scale kinetic models are used to study the dynamic response of a system to a specific input or stimulus.

Drug Discovery

Reinforcement learning and Bayesian data assimilation for model-informed precision dosing in oncology

no code implementations • 1 Jun 2020 • Corinna Maier, Niklas Hartung, Charlotte Kloft, Wilhelm Huisinga, Jana de Wiljes

Model-informed precision dosing (MIPD) using therapeutic drug/biomarker monitoring offers the opportunity to significantly improve the efficacy and safety of drug therapies.

reinforcement-learning Reinforcement Learning (RL)