The low-entropy hydration shell at the binding site of spike RBD determines the contagiousness of SARS-CoV-2 variants

no code implementations • 27 Apr 2022 • Lin Yang, Shuai Guo, Chengyu Houc, Jiacheng Lia, Liping Shi, Chenchen Liao, Rongchun Shi, Xiaoliang Ma, Bing Zheng, Yi Fang, Lin Ye, Xiaodong He

The low-entropy level of hydration shells at the binding site of a spike protein is found to be an important indicator of the contagiousness of the coronavirus.

The role of hydrophobic interactions in folding of $β$-sheets

no code implementations • 16 Sep 2020 • Jiacheng Li, Xiaoliang Ma, Hongchi Zhang, Chengyu Hou, Liping Shi, Shuai Guo, Chenchen Liao, Bing Zheng, Lin Ye, Lin Yang, Xiaodong He

Exploring the protein-folding problem has been a long-standing challenge in molecular biology.

Protein Folding