Search Results for author: Chengyu Hou

Found 4 papers, 0 papers with code

Space Layout of Low-entropy Hydration Shells Guides Protein Binding

no code implementations22 Feb 2022 Lin Yang, Shuai Guo, Chengyu Hou, Chencheng Liao, Jiacheng Li, Liping Shi, Xiaoliang Ma, Shenda Jiang, Bing Zheng, Yi Fang, Lin Ye, Xiaodong He

According to an analysis of determined protein complex structures, shape matching between the largest low-entropy hydration shell region of a protein and that of its partner at the binding sites is revealed as a regular pattern.

Hydrophobic interaction determines docking affinity of SARS CoV 2 variants with antibodies

no code implementations28 Feb 2021 Jiacheng Li, Chengyu Hou, Menghao Wang, Chencheng Liao, Shuai Guo, Liping Shi, Xiaoliang Ma, Hongchi Zhang, Shenda Jiang, Bing Zheng, Lin Ye, Lin Yang, Xiaodong He

Preliminary epidemiologic, phylogenetic and clinical findings suggest that several novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have increased transmissibility and decreased efficacy of several existing vaccines.

A hydrophobic-interaction-based mechanism trigger docking between the SARS CoV 2 spike and angiotensin-converting enzyme 2

no code implementations27 Aug 2020 Jiacheng Li, Xiaoliang Ma, Shuai Guo, Chengyu Hou, Liping Shi, Hongchi Zhang, Bing Zheng, Chencheng Liao, Lin Yang, Lin Ye, Xiaodong He

The hydrophobic interaction between the SARS-CoV-2 S and ACE2 protein is found to be significantly greater than that between SARS-CoV S and ACE2.

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