no code implementations • 29 May 2023 • Philippe Weitz, Masi Valkonen, Leslie Solorzano, Circe Carr, Kimmo Kartasalo, Constance Boissin, Sonja Koivukoski, Aino Kuusela, Dusan Rasic, Yanbo Feng, Sandra Sinius Pouplier, Abhinav Sharma, Kajsa Ledesma Eriksson, Stephanie Robertson, Christian Marzahl, Chandler D. Gatenbee, Alexander R. A. Anderson, Marek Wodzinski, Artur Jurgas, Niccolò Marini, Manfredo Atzori, Henning Müller, Daniel Budelmann, Nick Weiss, Stefan Heldmann, Johannes Lotz, Jelmer M. Wolterink, Bruno De Santi, Abhijeet Patil, Amit Sethi, Satoshi Kondo, Satoshi Kasai, Kousuke Hirasawa, Mahtab Farrokh, Neeraj Kumar, Russell Greiner, Leena Latonen, Anne-Vibeke Laenkholm, Johan Hartman, Pekka Ruusuvuori, Mattias Rantalainen
The alignment of tissue between histopathological whole-slide-images (WSI) is crucial for research and clinical applications.
no code implementations • 6 Apr 2022 • Marc Aubreville, Nikolas Stathonikos, Christof A. Bertram, Robert Klopleisch, Natalie ter Hoeve, Francesco Ciompi, Frauke Wilm, Christian Marzahl, Taryn A. Donovan, Andreas Maier, Jack Breen, Nishant Ravikumar, Youjin Chung, Jinah Park, Ramin Nateghi, Fattaneh Pourakpour, Rutger H. J. Fick, Saima Ben Hadj, Mostafa Jahanifar, Nasir Rajpoot, Jakob Dexl, Thomas Wittenberg, Satoshi Kondo, Maxime W. Lafarge, Viktor H. Koelzer, Jingtang Liang, YuBo Wang, Xi Long, Jingxin Liu, Salar Razavi, April Khademi, Sen yang, Xiyue Wang, Mitko Veta, Katharina Breininger
The goal of the MICCAI MIDOG 2021 challenge has been to propose and evaluate methods that counter this domain shift and derive scanner-agnostic mitosis detection algorithms.
1 code implementation • 27 Jan 2022 • Frauke Wilm, Marco Fragoso, Christian Marzahl, Jingna Qiu, Chloé Puget, Laura Diehl, Christof A. Bertram, Robert Klopfleisch, Andreas Maier, Katharina Breininger, Marc Aubreville
Due to morphological similarities, the differentiation of histologic sections of cutaneous tumors into individual subtypes can be challenging.
no code implementations • 19 Jan 2022 • Mathias Öttl, Jana Mönius, Christian Marzahl, Matthias Rübner, Carol I. Geppert, Arndt Hartmann, Matthias W. Beckmann, Peter Fasching, Andreas Maier, Ramona Erber, Katharina Breininger
When evaluating the approaches on fully manually annotated images, we observe that the autoencoder-based superpixels achieve a 23% increase in boundary F1 score compared to the baseline SLIC superpixels.
no code implementations • 5 Nov 2021 • Sonja Kunzmann, Christian Marzahl, Felix Denzinger, Christof A. Bertram, Robert Klopfleisch, Katharina Breininger, Vincent Christlein, Andreas Maier
Annotating data, especially in the medical domain, requires expert knowledge and a lot of effort.
no code implementations • 25 Aug 2021 • Frauke Wilm, Christian Marzahl, Katharina Breininger, Marc Aubreville
This work presents a mitotic figure detection algorithm developed as a baseline for the challenge, based on domain adversarial training.
1 code implementation • 19 Aug 2021 • Christian Marzahl, Jenny Hill, Jason Stayt, Dorothee Bienzle, Lutz Welker, Frauke Wilm, Jörn Voigt, Marc Aubreville, Andreas Maier, Robert Klopfleisch, Katharina Breininger, Christof A. Bertram
Pulmonary hemorrhage (P-Hem) occurs among multiple species and can have various causes.
1 code implementation • MICCAI Workshop COMPAY 2021 • Christian Marzahl, Frauke Wilm, Christine Kröger, Franz F Dressler, Lars Tharun, Sven Perner, Christof Bertram, Jörn Voigt, Robert Klopfleisch, Andreas Maier, Marc Aubreville, Katharina Breininger
The registration of whole slide images (WSIs) provides the basis for many subsequent processing steps in digital pathology.
no code implementations • 13 Jan 2021 • Christian Marzahl, Christof A. Bertram, Frauke Wilm, Jörn Voigt, Ann K. Barton, Robert Klopfleisch, Katharina Breininger, Andreas Maier, Marc Aubreville
We evaluated our pipeline in a cross-validation setup with a fixed training set using a dataset of six equine WSIs of which four are partially annotated and used for training, and two fully annotated WSI are used for validation and testing.
2 code implementations • 5 Jan 2021 • Christof A. Bertram, Taryn A. Donovan, Marco Tecilla, Florian Bartenschlager, Marco Fragoso, Frauke Wilm, Christian Marzahl, Katharina Breininger, Andreas Maier, Robert Klopfleisch, Marc Aubreville
For this study, we created the first open source data-set with 19, 983 annotations of BiNC and 1, 416 annotations of MuNC in 32 histological whole slide images of ccMCT.
no code implementations • 4 Dec 2020 • Frauke Wilm, Christof A. Bertram, Christian Marzahl, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Kathrin Becker, Mark Bennett, Sarah Corner, Brieuc Cossic, Daniela Denk, Martina Dettwiler, Beatriz Garcia Gonzalez, Corinne Gurtner, Annika Lehmbecker, Sophie Merz, Stephanie Plog, Anja Schmidt, Rebecca C. Smedley, Marco Tecilla, Tuddow Thaiwong, Katharina Breininger, Matti Kiupel, Andreas Maier, Robert Klopfleisch, Marc Aubreville
Density of mitotic figures in histologic sections is a prognostically relevant characteristic for many tumours.
1 code implementation • 24 Aug 2020 • Marc Aubreville, Christof A. Bertram, Taryn A. Donovan, Christian Marzahl, Andreas Maier, Robert Klopfleisch
We achieved a mean F1-score of 0. 791 on the test set and of up to 0. 696 on a human breast cancer dataset.
1 code implementation • 10 Jul 2020 • Christof A. Bertram, Mitko Veta, Christian Marzahl, Nikolas Stathonikos, Andreas Maier, Robert Klopfleisch, Marc Aubreville
To date, some datasets on mitotic figures are available and were used for development of promising deep learning-based algorithms.
2 code implementations • 30 Apr 2020 • Christian Marzahl, Marc Aubreville, Christof A. Bertram, Jennifer Maier, Christian Bergler, Christine Kröger, Jörn Voigt, Katharina Breininger, Robert Klopfleisch, Andreas Maier
In many research areas, scientific progress is accelerated by multidisciplinary access to image data and their interdisciplinary annotation.
1 code implementation • 13 Apr 2020 • Christian Marzahl, Christof A. Bertram, Marc Aubreville, Anne Petrick, Kristina Weiler, Agnes C. Gläsel, Marco Fragoso, Sophie Merz, Florian Bartenschlager, Judith Hoppe, Alina Langenhagen, Anne Jasensky, Jörn Voigt, Robert Klopfleisch, Andreas Maier
However, a significant percentage of the deliberately introduced false labels was not identified by the experts.
Human-Computer Interaction Image and Video Processing
no code implementations • 25 Nov 2019 • Marc Aubreville, Christof A. Bertram, Samir Jabari, Christian Marzahl, Robert Klopfleisch, Andreas Maier
We were able to show that domain adversarial training considerably improves accuracy when applying mitotic figure classification learned from the canine on the human data sets (up to +12. 8% in accuracy) and is thus a helpful method to transfer knowledge from existing data sets to new tissue types and species.
2 code implementations • 12 Aug 2019 • Christian Marzahl, Marc Aubreville, Christof A. Bertram, Jason Stayt, Anne-Katherine Jasensky, Florian Bartenschlager, Marco Fragoso-Garcia, Ann K. Barton, Svenja Elsemann, Samir Jabari, Jens Krauth, Prathmesh Madhu, Jörn Voigt, Jenny Hill, Robert Klopfleisch, Andreas Maier
Additionally, we evaluated object detection methods on a novel data set of 17 completely annotated cytology whole slide images (WSI) containing 78, 047 hemosiderophages.
1 code implementation • 12 Feb 2019 • Marc Aubreville, Christof A. Bertram, Christian Marzahl, Corinne Gurtner, Martina Dettwiler, Anja Schmidt, Florian Bartenschlager, Sophie Merz, Marco Fragoso, Olivia Kershaw, Robert Klopfleisch, Andreas Maier
Manual count of mitotic figures, which is determined in the tumor region with the highest mitotic activity, is a key parameter of most tumor grading schemes.