no code implementations • 9 Mar 2024 • Elise Grosjean, Alex Keilmann, Henry Jäger, Shimi Mohanan, Claudia Redenbach, Bernd Simeon, Christina Surulescu, Luisa de Roy, Andreas Seitz, Graciosa Teixeira, Martin Dauner, Carsten Linti, Günter Schmidt
We develop a model the dynamics of human mesenchymal stem cells (hMSCs) and chondrocytes evolving in a nonwoven polyethylene terephtalate (PET) scaffold impregnated with hyaluron and supplied with a differentiation medium.
no code implementations • 22 Mar 2022 • Martina Conte, Yvonne Dzierma, Sven Knobe, Christina Surulescu
A multiscale model for glioma spread in brain tissue under the influence of vascularization and vascular endothelial growth factors is proposed.
no code implementations • 29 Jun 2021 • Pawan Kumar, Christina Surulescu, Anna Zhigun
We propose a multiphase modeling approach to describe glioma pseudopalisade patterning under the influence of acidosis.
no code implementations • 7 Oct 2020 • Anne Dietrich, Niklas Kolbe, Nikolaos Sfakianakis, Christina Surulescu
We propose a novel approach to modeling cell migration in an anisotropic environment with biochemical heterogeneity and interspecies interactions, using as a paradigm glioma invasion in brain tissue under the influence of hypoxia-triggered angiogenesis.
no code implementations • 21 Sep 2020 • Pawan Kumar, Christina Surulescu
We propose a model for glioma patterns in a microlocal tumor environment under the influence of acidity, angiogenesis, and tissue anisotropy.
no code implementations • 23 Jul 2020 • Martina Conte, Christina Surulescu
Starting from kinetic transport equations and subcellular dynamics we deduce a multiscale model for glioma invasion relying on the go-or-grow dichotomy and the influence of vasculature, acidity, and brain tissue anisotropy.
no code implementations • 10 Jul 2020 • Pawan Kumar, Jing Li, Christina Surulescu
Moreover, we study two different types of scaling and compare the behavior of the obtained macroscopic PDEs by way of simulations.
