1 code implementation • 31 Oct 2018 • Nicholas J. Seewald, Kelley M. Kidwell, Inbal Nahum-Shani, Tianshuang Wu, James R. McKay, Daniel Almirall
We show that the sample size formula for a SMART can be written as the product of the sample size formula for a standard two-arm randomized trial, a deflation factor that accounts for the increased statistical efficiency resulting from a repeated-measures analysis, and an inflation factor that accounts for the design of a SMART.
Methodology