no code implementations • 12 Oct 2022 • Enze Xu, Jingwen Zhang, Jiadi Li, Qianqian Song, Defu Yang, Guorong Wu, Minghan Chen
Alzheimer's disease (AD) is a heterogeneous, multifactorial neurodegenerative disorder characterized by beta-amyloid, pathologic tau, and neurodegeneration.
no code implementations • 22 Jan 2022 • Jingwen Zhang, Qing Liu, Haorui Zhang, Michelle Dai, Qianqian Song, Defu Yang, Guorong Wu, Minghan Chen
Background: Despite the striking efforts in investigating neurobiological factors behind the acquisition of amyloid-\b{eta} (A), protein tau (T), and neurodegeneration ([N]) biomarkers, the mechanistic pathways of how AT[N] biomarkers spreading throughout the brain remain elusive.
no code implementations • 7 Mar 2021 • Qing Liu, Defu Yang, Jingwen Zhang, Ziming Wei, Guorong Wu, Minghan Chen
Three major biomarkers: beta-amyloid (A), pathologic tau (T), and neurodegeneration (N), are recognized as valid proxies for neuropathologic changes of Alzheimer's disease.
no code implementations • 10 Sep 2020 • Jingwen Zhang, Defu Yang, wei he, Guorong Wu, Minghan Chen
Currently, many studies of Alzheimer's disease (AD) are investigating the neurobiological factors behind the acquisition of beta-amyloid (A), pathologic tau (T), and neurodegeneration ([N]) biomarkers from neuroimages.
no code implementations • 1 Jul 2020 • Jiazhou Chen, Guoqiang Han, Hongmin Cai, Defu Yang, Paul J. Laurienti, Martin Styner, Guorong Wu, Alzheimer's Disease Neuroimaging Initiative ADNI
To that end, we propose a novel connectome harmonic analysis framework to provide enhanced mathematical insights by detecting frequency-based alterations relevant to brain disorders.