Search Results for author: Defu Yang

Found 5 papers, 0 papers with code

Pathology Steered Stratification Network for Subtype Identification in Alzheimer's Disease

no code implementations12 Oct 2022 Enze Xu, Jingwen Zhang, Jiadi Li, Qianqian Song, Defu Yang, Guorong Wu, Minghan Chen

Alzheimer's disease (AD) is a heterogeneous, multifactorial neurodegenerative disorder characterized by beta-amyloid, pathologic tau, and neurodegeneration.

Uncovering the System Vulnerability and Criticality of Human Brain under Dynamical Neuropathological Events in Alzheimer's Disease

no code implementations22 Jan 2022 Jingwen Zhang, Qing Liu, Haorui Zhang, Michelle Dai, Qianqian Song, Defu Yang, Guorong Wu, Minghan Chen

Background: Despite the striking efforts in investigating neurobiological factors behind the acquisition of amyloid-\b{eta} (A), protein tau (T), and neurodegeneration ([N]) biomarkers, the mechanistic pathways of how AT[N] biomarkers spreading throughout the brain remain elusive.

Analyzing the Spatiotemporal Interaction and Propagation of ATN Biomarkers in Alzheimer's Disease using Longitudinal Neuroimaging Data

no code implementations7 Mar 2021 Qing Liu, Defu Yang, Jingwen Zhang, Ziming Wei, Guorong Wu, Minghan Chen

Three major biomarkers: beta-amyloid (A), pathologic tau (T), and neurodegeneration (N), are recognized as valid proxies for neuropathologic changes of Alzheimer's disease.

valid

A Network-Guided Reaction-Diffusion Model of AT[N] Biomarkers in Alzheimer's Disease

no code implementations10 Sep 2020 Jingwen Zhang, Defu Yang, wei he, Guorong Wu, Minghan Chen

Currently, many studies of Alzheimer's disease (AD) are investigating the neurobiological factors behind the acquisition of beta-amyloid (A), pathologic tau (T), and neurodegeneration ([N]) biomarkers from neuroimages.

Learning Common Harmonic Waves on Stiefel Manifold -- A New Mathematical Approach for Brain Network Analyses

no code implementations1 Jul 2020 Jiazhou Chen, Guoqiang Han, Hongmin Cai, Defu Yang, Paul J. Laurienti, Martin Styner, Guorong Wu, Alzheimer's Disease Neuroimaging Initiative ADNI

To that end, we propose a novel connectome harmonic analysis framework to provide enhanced mathematical insights by detecting frequency-based alterations relevant to brain disorders.

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