no code implementations • 4 Jul 2023 • Changjian Shui, Justin Szeto, Raghav Mehta, Douglas L. Arnold, Tal Arbel
However, models that are well calibrated overall can still be poorly calibrated for a sub-population, potentially resulting in a clinician unwittingly making poor decisions for this group based on the recommendations of the model.
no code implementations • 5 May 2023 • Joshua Durso-Finley, Jean-Pierre Falet, Raghav Mehta, Douglas L. Arnold, Nick Pawlowski, Tal Arbel
We evaluate the correlation of the uncertainty estimate with the factual error, and, given the lack of ground truth counterfactual outcomes, demonstrate how uncertainty for the ITE prediction relates to bounds on the ITE error.
no code implementations • 15 Nov 2022 • Anjun Hu, Jean-Pierre R. Falet, Brennan S. Nichyporuk, Changjian Shui, Douglas L. Arnold, Sotirios A. Tsaftaris, Tal Arbel
We propose a hierarchically structured variational inference model for accurately disentangling observable evidence of disease (e. g. brain lesions or atrophy) from subject-specific anatomy in brain MRIs.
no code implementations • 31 Oct 2022 • Brennan Nichyporuk, Jillian Cardinell, Justin Szeto, Raghav Mehta, Jean-Pierre R. Falet, Douglas L. Arnold, Sotirios A. Tsaftaris, Tal Arbel
This is particularly important in the context of medical image segmentation of pathological structures (e. g. lesions), where the annotation process is much more subjective, and affected by a number underlying factors, including the annotation protocol, rater education/experience, and clinical aims, among others.
1 code implementation • 11 Aug 2022 • Chelsea Myers-Colet, Julien Schroeter, Douglas L. Arnold, Tal Arbel
In many clinical contexts, detecting all lesions is imperative for evaluating disease activity.
no code implementations • 3 Aug 2022 • Amar Kumar, Anjun Hu, Brennan Nichyporuk, Jean-Pierre R. Falet, Douglas L. Arnold, Sotirios Tsaftaris, Tal Arbel
In this work, we demonstrate that data-driven biomarker discovery can be achieved through a counterfactual synthesis process.
no code implementations • 1 Apr 2022 • Joshua Durso-Finley, Jean-Pierre R. Falet, Brennan Nichyporuk, Douglas L. Arnold, Tal Arbel
Precision medicine for chronic diseases such as multiple sclerosis (MS) involves choosing a treatment which best balances efficacy and side effects/preferences for individual patients.
no code implementations • 2 Aug 2021 • Brennan Nichyporuk, Jillian Cardinell, Justin Szeto, Raghav Mehta, Sotirios Tsaftaris, Douglas L. Arnold, Tal Arbel
Many automatic machine learning models developed for focal pathology (e. g. lesions, tumours) detection and segmentation perform well, but do not generalize as well to new patient cohorts, impeding their widespread adoption into real clinical contexts.
no code implementations • 27 Jul 2021 • Brennan Nichyporuk, Justin Szeto, Douglas L. Arnold, Tal Arbel
There are many clinical contexts which require accurate detection and segmentation of all focal pathologies (e. g. lesions, tumours) in patient images.
1 code implementation • 3 Aug 2018 • Tanya Nair, Doina Precup, Douglas L. Arnold, Tal Arbel
We present the first exploration of multiple uncertainty estimates based on Monte Carlo (MC) dropout [4] in the context of deep networks for lesion detection and segmentation in medical images.