no code implementations • 20 Dec 2021 • Nils R. Winter, Ramona Leenings, Jan Ernsting, Kelvin Sarink, Lukas Fisch, Daniel Emden, Julian Blanke, Janik Goltermann, Nils Opel, Carlotta Barkhau, Susanne Meinert, Katharina Dohm, Jonathan Repple, Marco Mauritz, Marius Gruber, Elisabeth J. Leehr, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Igor Nenadic, Markus Nöthen, Andreas Forstner, Marcella Rietschel, Joachim Groß, Jochen Bauer, Walter Heindel, Till Andlauer, Simon Eickhoff, Tilo Kircher, Udo Dannlowski, Tim Hahn
Discussion: We provide a large-scale, multimodal analysis of univariate biological differences between MDD patients and controls and show that even under near-ideal conditions and for maximum biological differences, deviations are extremely small and similarity dominates.
no code implementations • 14 Dec 2021 • Tim Hahn, Hamidreza Jamalabadi, Erfan Nozari, Nils R. Winter, Jan Ernsting, Marius Gruber, Marco J. Mauritz, Pascal Grumbach, Lukas Fisch, Ramona Leenings, Kelvin Sarink, Julian Blanke, Leon Kleine Vennekate, Daniel Emden, Nils Opel, Dominik Grotegerd, Verena Enneking, Susanne Meinert, Tiana Borgers, Melissa Klug, Elisabeth J. Leehr, Katharina Dohm, Walter Heindel, Joachim Gross, Udo Dannlowski, Ronny Redlich, Jonathan Repple
We show that whole-brain controllability metrics based on pre-ECT structural connectome data predict ECT response in accordance with our hypotheses.
no code implementations • 21 Jul 2021 • Tim Hahn, Hamidreza Jamalabadi, Daniel Emden, Janik Goltermann, Jan Ernsting, Nils R. Winter, Lukas Fisch, Ramona Leenings, Kelvin Sarink, Vincent Holstein, Marius Gruber, Dominik Grotegerd, Susanne Meinert, Katharina Dohm, Elisabeth J. Leehr, Maike Richter, Lisa Sindermann, Verena Enneking, Hannah Lemke, Stephanie Witt, Marcella Rietschel, Katharina Brosch, Julia-Katharina Pfarr, Tina Meller, Kai Gustav Ringwald, Simon Schmitt, Frederike Stein, Igor Nenadic, Tilo Kircher, Bertram Müller-Myhsok, Till F. M. Andlauer, Jonathan Repple, Udo Dannlowski, Nils Opel
We quantified the theoretical energy required for each patient and time-point to reach a symptom-free state given individual symptom-network topology (E 0 ) and 1) tested if E 0 predicts future symptom improvement and 2) whether this relationship is moderated by Polygenic Risk Scores (PRS) of mental disorders, childhood maltreatment experience, and self-reported resilience.