Search Results for author: Eric F. Lock

Found 14 papers, 14 papers with code

Multiple Augmented Reduced Rank Regression for Pan-Cancer Analysis

1 code implementation30 Aug 2023 Jiuzhou Wang, Eric F. Lock

To address variation architectures correctly and comprehensively for high-dimensional data across multiple sample sets (i. e., cohorts), we propose multiple augmented reduced rank regression (maRRR), a flexible matrix regression and factorization method to concurrently learn both covariate-driven and auxiliary structured variation.

Imputation regression

Bayesian Simultaneous Factorization and Prediction Using Multi-Omic Data

2 code implementations29 Nov 2022 Sarah Samorodnitsky, Chris H. Wendt, Eric F. Lock

We show via simulation that BSFP is competitive in recovering latent variation structure, as well as the importance of propagating uncertainty from the estimated factorization to prediction.

Imputation

Bayesian predictive modeling of multi-source multi-way data

1 code implementation5 Aug 2022 Jonathan Kim, Brian J. Sandri, Raghavendra B. Rao, Eric F. Lock

We develop a Bayesian approach to predict a continuous or binary outcome from data that are collected from multiple sources with a multi-way (i. e.. multidimensional tensor) structure.

Robust classification

Multiway sparse distance weighted discrimination

1 code implementation11 Oct 2021 Bin Guo, Lynn E. Eberly, Pierre-Gilles Henry, Christophe Lenglet, Eric F. Lock

We conducted extensive simulation studies, showing that our model is robust to the degree of sparsity and improves classification accuracy when the data have multiway structure.

Classification

sJIVE: Supervised Joint and Individual Variation Explained

1 code implementation26 Feb 2021 Elise F. Palzer, Christine Wendt, Russell Bowler, Craig P. Hersh, Sandra E. Safo, Eric F. Lock

We propose a method called supervised joint and individual variation explained (sJIVE) that can simultaneously (1) identify shared (joint) and source-specific (individual) underlying structure and (2) build a linear prediction model for an outcome using these structures.

Bayesian Distance Weighted Discrimination

1 code implementation7 Oct 2020 Eric F. Lock

In this article we show that DWD identifies the mode of a proper Bayesian posterior distribution, that results from a particular link function for the class probabilities and a shrinkage-inducing proper prior distribution on the coefficients.

Bidimensional linked matrix factorization for pan-omics pan-cancer analysis

2 code implementations7 Feb 2020 Eric F. Lock, Jun Young Park, Katherine A. Hoadley

This builds on a growing literature for the factorization and decomposition of linked matrices, which has primarily focused on multiple matrices that are linked in one dimension (rows or columns) only.

Integrative Factorization of Bidimensionally Linked Matrices

1 code implementation9 Jun 2019 Jun Young Park, Eric F. Lock

This is limiting for data that take the form of bidimensionally linked matrices (e. g., multiple cohorts measured on multiple platforms), which are increasingly common in large-scale biomedical studies.

Dimensionality Reduction

Bayesian nonparametric multiway regression for clustered binomial data

1 code implementation31 Jan 2019 Eric F. Lock, Dipankar Bandyopadhyay

We introduce a Bayesian nonparametric regression model for data with multiway (tensor) structure, motivated by an application to periodontal disease (PD) data.

Clustering regression

Detecting Multiple Random Changepoints in Bayesian Piecewise Growth Mixture Models

1 code implementation29 Oct 2017 Eric F. Lock, Nidhi Kohli, Maitreyee Bose

A random changepoint allows for individual differences in the transition time within each class.

Methodology

Tensor-on-tensor regression

1 code implementation4 Jan 2017 Eric F. Lock

We propose a framework for the linear prediction of a multi-way array (i. e., a tensor) from another multi-way array of arbitrary dimension, using the contracted tensor product.

regression

Supervised multiway factorization

1 code implementation11 Sep 2016 Eric F. Lock, Gen Li

We describe a likelihood-based latent variable representation of the CP factorization, in which the latent variables are informed by additional covariates.

Dimensionality Reduction

Discriminating sample groups with multi-way data

1 code implementation26 Jun 2016 Tianmeng Lyu, Eric F. Lock, Lynn E. Eberly

However, their use is limited to applications where a single vector of features is measured for each subject.

General Classification

Joint and individual variation explained (JIVE) for integrated analysis of multiple data types

1 code implementation20 Feb 2011 Eric F. Lock, Katherine A. Hoadley, J. S. Marron, Andrew B. Nobel

In this paper we introduce Joint and Individual Variation Explained (JIVE), a general decomposition of variation for the integrated analysis of such data sets.

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