Incomplete resection of the icEEG seizure onset zone is not associated with post-surgical outcomes

no code implementations • 24 Nov 2023 • Sarah J. Gascoigne, Nathan Evans, Gerard Hall, Csaba Kozma, Mariella Panagiotopoulou, Gabrielle M. Schroeder, Callum Simpson, Christopher Thornton, Frances Turner, Heather Woodhouse, Jess Blickwedel, Fahmida Chowdhury, Beate Diehl, John S. Duncan, Ryan Faulder, Rhys H. Thomas, Kevin Wilson, Peter N. Taylor, Yujiang Wang

Retrospective analysis of icEEG recordings from 63 subjects (735 seizures) identified seizure onset regions through visual inspection and algorithmic delineation.

EEG

MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy

no code implementations • 13 Jul 2022 • Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor

Resting-state MEG data were acquired for 70 healthy controls and 32 patients with refractory neocortical epilepsy.

A library of quantitative markers of seizure severity

1 code implementation • 30 Jun 2022 • Sarah J. Gascoigne, Leonard Waldmann, Mariella Panagiotopoulou, Fahmida Chowdhury, Alison Cronie, Beate Diehl, John S. Duncan, Jennifer Falconer, Yu Guan, Veronica Leach, Shona Livingstone, Christoforos Papasavvas, Ryan Faulder, Jess Blickwedel, Gabrielle M. Schroeder, Rhys H. Thomas, Kevin Wilson, Peter N. Taylor, Yujiang Wang

In individual patients, 71% had a moderate to large difference (ranksum r > 0. 3) between focal and subclinical seizures in three or more markers.

EEG Seizure prediction

Volumetric and structural connectivity abnormalities co-localise in TLE

no code implementations • 5 Feb 2022 • Jonathan J. Horsley, Gabrielle M. Schroeder, Rhys H. Thomas, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S. Duncan, Yujiang Wang, Peter N. Taylor

We computed grey matter volumetric changes and white matter structural connectivity abnormalities in 144 patients with unilateral TLE and 96 healthy controls.

Chronic iEEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states

no code implementations • 27 Jan 2022 • Gabrielle M. Schroeder, Philippa J. Karoly, Matias Maturana, Mariella Panagiotopoulou, Peter N. Taylor, Mark J. Cook, Yujiang Wang

We then compared SNS occurrence and duration to (1) time since implantation and (2) patient-specific circadian and multidien cycles in interictal spike rate.

EEG

Seizure pathways and seizure durations can vary independently within individual patients with focal epilepsy

no code implementations • 14 Sep 2021 • Gabrielle M. Schroeder, Fahmida A. Chowdhury, Mark J. Cook, Beate Diehl, John S. Duncan, Philippa J. Karoly, Peter N. Taylor, Yujiang Wang

However, it is unclear whether seizures following the same pathway will have the same duration or if these features can vary independently.

EEG