no code implementations • 17 Sep 2022 • Heyrim Cho, Allison L. Lewis, Kathleen M. Storey, Helen M. Byrne
Structural identifiability of the Lotka-Volterra model is confirmed, and practical identifiability is assessed for three experimental designs: (a) use of a single data set, with a mixture of both cell lines observed over time, (b) a sequential design where growth rates and carrying capacities are estimated using data from experiments in which each cell line is grown in isolation, and then interaction parameters are estimated from an experiment involving a mixture of both cell lines, and (c) a parallel experimental design where all model parameters are fitted to data from two mixtures simultaneously.
no code implementations • 18 Jan 2022 • Runpeng Li, Prativa Sahoo, Dongrui Wang, Qixuan Wang, Christine E. Brown, Russell C. Rockne, Heyrim Cho
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated.
no code implementations • 25 Dec 2021 • Allison L. Lewis, Kathleen M. Storey, Heyrim Cho, Anna C. Zittle
Unlike the error analysis of the previous study, the inclusion of uncertainty analysis in this work|as a means for deciding when the algorithm can be terminated|provides a more realistic option for clinical decision-making, since it does not rely on data that will be collected later in time.
no code implementations • 28 Jan 2020 • Heyrim Cho, Zuping Wang, Doron Levy
Adoptive T cell based immunotherapy is gaining significant traction in cancer treatment.