Search Results for author: Jack E. Gibson

Found 7 papers, 0 papers with code

Supervised Adverse Drug Reaction Signalling Framework Imitating Bradford Hill's Causality Considerations

no code implementations21 Jul 2016 Jenna Marie Reps, Jonathan M. Garibaldi, Uwe Aickelin, Jack E. Gibson, Richard B. Hubbard

Due to these complexities, existing methods for large-scale detection of negative side effects using observational data all tend to have issues distinguishing between association and causality.

Attributes for Causal Inference in Longitudinal Observational Databases

no code implementations3 Sep 2014 Jenna Reps, Jonathan M. Garibaldi, Uwe Aickelin, Daniele Soria, Jack E. Gibson, Richard B. Hubbard

In this paper we investigate potential attributes that can be used in causal inference to identify side effects based on the Bradford-Hill causality criteria.

Causal Inference feature selection +2

A Novel Semi-Supervised Algorithm for Rare Prescription Side Effect Discovery

no code implementations2 Sep 2014 Jenna Reps, Jonathan M. Garibaldi, Uwe Aickelin, Daniele Soria, Jack E. Gibson, Richard B. Hubbard

Drugs are frequently prescribed to patients with the aim of improving each patient's medical state, but an unfortunate consequence of most prescription drugs is the occurrence of undesirable side effects.

Clustering Marketing +1

Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs

no code implementations2 Sep 2014 Jenna M. Reps, Jonathan M. Garibaldi, Uwe Aickelin, Daniele Soria, Jack E. Gibson, Richard B. Hubbard

Conclusion: This research shows that it is possible to exploit the mechanism of causality and presents a framework for signalling adverse drug reactions effectively.

Specificity

Comparing Data-mining Algorithms Developed for Longitudinal Observational Databases

no code implementations5 Jul 2013 Jenna Reps, Jonathan M. Garibaldi, Uwe Aickelin, Daniele Soria, Jack E. Gibson, Richard B. Hubbard

Longitudinal observational databases have become a recent interest in the post marketing drug surveillance community due to their ability of presenting a new perspective for detecting negative side effects.

Marketing

Discovering Sequential Patterns in a UK General Practice Database

no code implementations4 Jul 2013 Jenna Reps, Jonathan M. Garibaldi, Uwe Aickelin, Daniele Soria, Jack E. Gibson, Richard B. Hubbard

The wealth of computerised medical information becoming readily available presents the opportunity to examine patterns of illnesses, therapies and responses.

Investigating the Detection of Adverse Drug Events in a UK General Practice Electronic Health-Care Database

no code implementations3 Jul 2013 Jenna Reps, Jan Feyereisl, Jonathan M. Garibaldi, Uwe Aickelin, Jack E. Gibson, Richard B. Hubbard

In this paper, existing methods developed for spontaneous reporting databases are implemented on both a spontaneous reporting database and a general practice electronic health-care database and compared.

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