2 code implementations • 20 Jun 2023 • Lucas Czech, Jeffrey P. Spence, Moisés Expósito-Alonso
Pool sequencing is an efficient method for capturing genome-wide allele frequencies from multiple individuals, with broad applications such as studying adaptation in Evolve-and-Resequence experiments, monitoring of genetic diversity in wild populations, and genotype-to-phenotype mapping.
1 code implementation • NeurIPS 2020 • Jeffrey P. Spence
When all distributions in the model are members of exponential families and are conditionally conjugate, optimization schemes can often be derived by hand.
1 code implementation • NeurIPS 2018 • Jeffrey Chan, Valerio Perrone, Jeffrey P. Spence, Paul A. Jenkins, Sara Mathieson, Yun S. Song
To achieve this, two inferential challenges need to be addressed: (1) population data are exchangeable, calling for methods that efficiently exploit the symmetries of the data, and (2) computing likelihoods is intractable as it requires integrating over a set of correlated, extremely high-dimensional latent variables.