no code implementations • 16 Feb 2024 • Nadieh Khalili, Joey Spronck, Francesco Ciompi, Jeroen van der Laak, Geert Litjens
Deep learning algorithms, often critiqued for their 'black box' nature, traditionally fall short in providing the necessary transparency for trusted clinical use.
1 code implementation • 19 Dec 2023 • Clément Grisi, Geert Litjens, Jeroen van der Laak
Vision Transformers (ViTs) have ushered in a new era in computer vision, showcasing unparalleled performance in many challenging tasks.
no code implementations • 16 Jan 2023 • Yiping Jiao, Jeroen van der Laak, Shadi Albarqouni, Zhang Li, Tao Tan, Abhir Bhalerao, Jiabo Ma, Jiamei Sun, Johnathan Pocock, Josien P. W. Pluim, Navid Alemi Koohbanani, Raja Muhammad Saad Bashir, Shan E Ahmed Raza, Sibo Liu, Simon Graham, Suzanne Wetstein, Syed Ali Khurram, Thomas Watson, Nasir Rajpoot, Mitko Veta, Francesco Ciompi
Additionally, we present post-competition results where we show how the presented methods perform on an independent set of lung cancer slides, which was not part of the initial competition, as well as a comparison on lymphocyte assessment between presented methods and a panel of pathologists.
no code implementations • 13 Jul 2022 • Péter Bándi, Maschenka Balkenhol, Marcory van Dijk, Bram van Ginneken, Jeroen van der Laak, Geert Litjens
Furthermore, we show the effectiveness of repeated adaptation of networks from one cancer type to another to obtain multi-task metastasis detection networks.
no code implementations • 16 Sep 2021 • John-Melle Bokhorsta, Iris D. Nagtegaal, Filippo Fraggetta, Simona Vatrano, Wilma Mesker, Michael Vieth, Jeroen van der Laak, Francesco Ciompi
Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types.
1 code implementation • 24 Jun 2021 • Johannes Lotz, Nick Weiss, Jeroen van der Laak, Stefan Heldmann
Between re-stained sections, the median registration error is 2. 3 {\mu}m and 0. 9 {\mu}m in the two subsets of the HyReCo dataset.
no code implementations • 9 Dec 2020 • Caner Mercan, Maschenka Balkenhol, Roberto Salgado, Mark Sherman, Philippe Vielh, Willem Vreuls, Antonio Polonia, Hugo M. Horlings, Wilko Weichert, Jodi M. Carter, Peter Bult, Matthias Christgen, Carsten Denkert, Koen van de Vijver, Jeroen van der Laak, Francesco Ciompi
Nuclear pleomorphism, defined herein as the extent of abnormalities in the overall appearance of tumor nuclei, is one of the components of the three-tiered breast cancer grading.
1 code implementation • 22 Jun 2020 • Mart van Rijthoven, Maschenka Balkenhol, Karina Siliņa, Jeroen van der Laak, Francesco Ciompi
We propose HookNet, a semantic segmentation model for histopathology whole-slide images, which combines context and details via multiple branches of encoder-decoder convolutional neural networks.
1 code implementation • 5 Jun 2020 • Hans Pinckaers, Wouter Bulten, Jeroen van der Laak, Geert Litjens
As such, developing algorithms which do not require manual pixel-wise annotations, but can learn using only the clinical report would be a significant advancement for the field.
no code implementations • MIDL 2019 • David Tellez, Diederik Hoppener, Cornelis Verhoef, Dirk Grunhagen, Pieter Nierop, Michal Drozdzal, Jeroen van der Laak, Francesco Ciompi
Additionally, we trained multiple encoders with different training objectives, e. g. unsupervised and variants of MTL, and observed a positive correlation between the number of tasks in MTL and the system performance on the TUPAC16 dataset.
no code implementations • 11 Feb 2020 • Wouter Bulten, Maschenka Balkenhol, Jean-Joël Awoumou Belinga, Américo Brilhante, Aslı Çakır, Xavier Farré, Katerina Geronatsiou, Vincent Molinié, Guilherme Pereira, Paromita Roy, Günter Saile, Paulo Salles, Ewout Schaafsma, Joëlle Tschui, Anne-Marie Vos, Hester van Boven, Robert Vink, Jeroen van der Laak, Christina Hulsbergen-van de Kaa, Geert Litjens
We investigated the value of AI assistance for grading prostate biopsies.
no code implementations • MIDL 2019 • Jasper Linmans, Jeroen van der Laak, Geert Litjens
Furthermore, we show that the meta-loss function of M-heads improves OOD detection in terms of AUROC from 87. 4 to 88. 7.
Out-of-Distribution Detection Out of Distribution (OOD) Detection
no code implementations • 18 Jul 2019 • Wouter Bulten, Hans Pinckaers, Hester van Boven, Robert Vink, Thomas de Bel, Bram van Ginneken, Jeroen van der Laak, Christina Hulsbergen-van de Kaa, Geert Litjens
We developed a fully automated deep learning system to grade prostate biopsies.
no code implementations • 18 Feb 2019 • David Tellez, Geert Litjens, Peter Bandi, Wouter Bulten, John-Melle Bokhorst, Francesco Ciompi, Jeroen van der Laak
Stain variation is a phenomenon observed when distinct pathology laboratories stain tissue slides that exhibit similar but not identical color appearance.
1 code implementation • 7 Nov 2018 • David Tellez, Geert Litjens, Jeroen van der Laak, Francesco Ciompi
Second, a convolutional neural network (CNN) is trained on these compressed image representations to predict image-level labels, avoiding the need for fine-grained manual annotations.
no code implementations • 17 Aug 2018 • David Tellez, Maschenka Balkenhol, Irene Otte-Holler, Rob van de Loo, Rob Vogels, Peter Bult, Carla Wauters, Willem Vreuls, Suzanne Mol, Nico Karssemeijer, Geert Litjens, Jeroen van der Laak, Francesco Ciompi
Application of CNNs to hematoxylin and eosin (H&E) stained histological tissue sections is hampered by: (1) noisy and expensive reference standards established by pathologists, (2) lack of generalization due to staining variation across laboratories, and (3) high computational requirements needed to process gigapixel whole-slide images (WSIs).
no code implementations • 17 Aug 2018 • Wouter Bulten, Péter Bándi, Jeffrey Hoven, Rob van de Loo, Johannes Lotz, Nick Weiss, Jeroen van der Laak, Bram van Ginneken, Christina Hulsbergen-van de Kaa, Geert Litjens
The H&E slides were co-registered to the IHC slides.
no code implementations • 10 May 2017 • Babak Ehteshami Bejnordi, Guido Zuidhof, Maschenka Balkenhol, Meyke Hermsen, Peter Bult, Bram van Ginneken, Nico Karssemeijer, Geert Litjens, Jeroen van der Laak
Automated classification of histopathological whole-slide images (WSI) of breast tissue requires analysis at very high resolutions with a large contextual area.
no code implementations • 17 Mar 2017 • Péter Bándi, Rob van de Loo, Milad Intezar, Daan Geijs, Francesco Ciompi, Bram van Ginneken, Jeroen van der Laak, Geert Litjens
Tissue segmentation is an important pre-requisite for efficient and accurate diagnostics in digital pathology.
1 code implementation • 20 Feb 2017 • Francesco Ciompi, Oscar Geessink, Babak Ehteshami Bejnordi, Gabriel Silva de Souza, Alexi Baidoshvili, Geert Litjens, Bram van Ginneken, Iris Nagtegaal, Jeroen van der Laak
The development of reliable imaging biomarkers for the analysis of colorectal cancer (CRC) in hematoxylin and eosin (H&E) stained histopathology images requires an accurate and reproducible classification of the main tissue components in the image.
no code implementations • 19 Feb 2017 • Babak Ehteshami Bejnordi, Jimmy Linz, Ben Glass, Maeve Mullooly, Gretchen L Gierach, Mark E Sherman, Nico Karssemeijer, Jeroen van der Laak, Andrew H. Beck
Diagnosis of breast carcinomas has so far been limited to the morphological interpretation of epithelial cells and the assessment of epithelial tissue architecture.