Search Results for author: John L. Sapp

Found 10 papers, 4 papers with code

Few-shot Generation of Personalized Neural Surrogates for Cardiac Simulation via Bayesian Meta-Learning

1 code implementation6 Oct 2022 Xiajun Jiang, Zhiyuan Li, Ryan Missel, Md Shakil Zaman, Brian Zenger, Wilson W. Good, Rob S. MacLeod, John L. Sapp, Linwei Wang

As test time, metaPNS delivers a personalized neural surrogate by fast feed-forward embedding of a small and flexible number of data available from an individual, achieving -- for the first time -- personalization and surrogate construction for expensive simulations in one end-to-end learning framework.

Meta-Learning Variational Inference

Fast Posterior Estimation of Cardiac Electrophysiological Model Parameters via Bayesian Active Learning

no code implementations13 Oct 2021 Md Shakil Zaman, Jwala Dhamala, Pradeep Bajracharya, John L. Sapp, B. Milan Horacek, Katherine C. Wu, Natalia A. Trayanova, Linwei Wang

In this paper, we present a Bayesian active learning method to directly approximate the posterior pdf function of cardiac model parameters, in which we intelligently select training points to query the simulation model in order to learn the posterior pdf using a small number of samples.

Active Learning

Quantifying the Uncertainty in Model Parameters Using Gaussian Process-Based Markov Chain Monte Carlo: An Application to Cardiac Electrophysiological Models

no code implementations2 Jun 2020 Jwala Dhamala, John L. Sapp, B. Milan Horácek, Linwei Wang

However, by sampling from an approximation of the exact posterior probability density function (pdf) of the parameters, the efficiency is gained at the expense of sampling accuracy.

Computational Efficiency

Bayesian Optimization on Large Graphs via a Graph Convolutional Generative Model: Application in Cardiac Model Personalization

1 code implementation1 Jul 2019 Jwala Dhamala, Sandesh Ghimire, John L. Sapp, B. Milan Horacek, Linwei Wang

In this paper, we present a novel graph convolutional VAE to allow generative modeling of non-Euclidean data, and utilize it to embed Bayesian optimization of large graphs into a small latent space.

Bayesian Optimization

Generative Modeling and Inverse Imaging of Cardiac Transmembrane Potential

no code implementations12 May 2019 Sandesh Ghimire, Jwala Dhamala, Prashnna Kumar Gyawali, John L. Sapp, B. Milan Horacek, Linwei Wang

We introduce a novel model-constrained inference framework that replaces conventional physiological models with a deep generative model trained to generate TMP sequences from low-dimensional generative factors.

Deep Generative Model with Beta Bernoulli Process for Modeling and Learning Confounding Factors

no code implementations31 Oct 2018 Prashnna K Gyawali, Cameron Knight, Sandesh Ghimire, B. Milan Horacek, John L. Sapp, Linwei Wang

While deep representation learning has become increasingly capable of separating task-relevant representations from other confounding factors in the data, two significant challenges remain.

Representation Learning

Improving Generalization of Sequence Encoder-Decoder Networks for Inverse Imaging of Cardiac Transmembrane Potential

no code implementations12 Oct 2018 Sandesh Ghimire, Prashnna Kumar Gyawali, John L. Sapp, Milan Horacek, Linwei Wang

The results demonstrate that the generalization ability of an inverse reconstruction network can be improved by constrained stochasticity combined with global aggregation of temporal information in the latent space.

Learning Theory

Learning disentangled representation from 12-lead electrograms: application in localizing the origin of Ventricular Tachycardia

1 code implementation4 Aug 2018 Prashnna K Gyawali, B. Milan Horacek, John L. Sapp, Linwei Wang

In this work, we present a conditional variational autoencoder (VAE) to extract the subject-specific adjustment to the ECG data, conditioned on task-specific representations learned from a deterministic encoder.

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