Search Results for author: Jonathan R. Walsh

Found 6 papers, 1 papers with code

Prognostic Covariate Adjustment for Logistic Regression in Randomized Controlled Trials

no code implementations29 Feb 2024 Yunfan Li, Arman Sabbaghi, Jonathan R. Walsh, Charles K. Fisher

We demonstrate that prognostic score adjustment in logistic regression increases the power of the Wald test for the conditional odds ratio under a fixed sample size, or alternatively reduces the necessary sample size to achieve a desired power, compared to the unadjusted analysis.

regression

Modeling Disease Progression in Mild Cognitive Impairment and Alzheimer's Disease with Digital Twins

no code implementations24 Dec 2020 Daniele Bertolini, Anton D. Loukianov, Aaron M. Smith, David Li-Bland, Yannick Pouliot, Jonathan R. Walsh, Charles K. Fisher

Alzheimer's Disease (AD) is a neurodegenerative disease that affects subjects in a broad range of severity and is assessed in clinical trials with multiple cognitive and functional instruments.

Generating Digital Twins with Multiple Sclerosis Using Probabilistic Neural Networks

no code implementations4 Feb 2020 Jonathan R. Walsh, Aaron M. Smith, Yannick Pouliot, David Li-Bland, Anton Loukianov, Charles K. Fisher

Multiple Sclerosis (MS) is a neurodegenerative disorder characterized by a complex set of clinical assessments.

Boltzmann Encoded Adversarial Machines

1 code implementation23 Apr 2018 Charles K. Fisher, Aaron M. Smith, Jonathan R. Walsh

Restricted Boltzmann Machines (RBMs) are a class of generative neural network that are typically trained to maximize a log-likelihood objective function.

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