Cellular tango: How extracellular matrix adhesion choreographs Rac-Rho signaling and cell movement

no code implementations • 19 Apr 2021 • Elisabeth G. Rens, Leah Edelstein-Keshet

The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge.

Bridging from single to collective cell migration: A review of models and links to experiments

no code implementations • 21 Nov 2020 • Andreas Buttenschön, Leah Edelstein-Keshet

Mathematical and computational models can assist in gaining an understanding of cell behavior at many levels of organization.

Spots, strips, and spiral waves in models for static and motile cells

no code implementations • 23 Sep 2019 • Yue Liu, Elisabeth G. Rens, Leah Edelstein-Keshet

The polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases.

Cell size, mechanical tension, and GTPase signaling in the Single Cell

no code implementations • 28 Aug 2019 • Andreas Buttenschön, Yue Liu, Leah Edelstein-Keshet

We further consider the feedback between mechanical tension, GTPase activation, and cell deformation in both static, growing, shrinking, and moving cells.