Search Results for author: Luis M. Rocha

Found 10 papers, 4 papers with code

Dynamical Modularity in Automata Models of Biochemical Networks

1 code implementation29 Mar 2023 Thomas Parmer, Luis M. Rocha

We present a novel algorithm to automatically extract pathway modules from networks and we characterize the interactions that may take place between modules.

On the feasibility of dynamical analysis of network models of biochemical regulation

no code implementations20 Oct 2021 Luis M. Rocha

A recent article by Weidner et al. [2021] presents a method to extract graph properties that are predictive of the dynamical behavior of multivariate, discrete models of biochemical regulation.

The distance backbone of complex networks

1 code implementation8 Mar 2021 Tiago Simas, Rion Brattig Correia, Luis M. Rocha

Redundancy needs more precise characterization as it is a major factor in the evolution and robustness of networks of multivariate interactions.

Effective connectivity determines the critical dynamics of biochemical networks

no code implementations20 Jan 2021 Santosh Manicka, Manuel Marques-Pita, Luis M. Rocha

This parsimony in the number of parameters needed sometimes leads to uncertain predictions about the dynamical regime of both random and systems biology models of biochemical regulation.

City-wide Analysis of Electronic Health Records Reveals Gender and Age Biases in the Administration of Known Drug-Drug Interactions

1 code implementation9 Mar 2018 Rion Brattig Correia, Luciana P. de Araújo, Mauro M. Mattos, Luis M. Rocha

The occurrence of drug-drug-interactions (DDI) from multiple drug dispensations is a serious problem, both for individuals and health-care systems, since patients with complications due to DDI are likely to reenter the system at a costlier level.

Management

Monitoring Potential Drug Interactions and Reactions via Network Analysis of Instagram User Timelines

no code implementations5 Oct 2015 Rion Brattig Correia, Lang Li, Luis M. Rocha

This demonstrates that Instagram contains much drug- and pathology specific data for public health monitoring of DDI and ADR, and that complex network analysis provides an important toolbox to extract health-related associations and their support from large-scale social media data.

Modularity and the spread of perturbations in complex dynamical systems

1 code implementation15 Sep 2015 Artemy Kolchinsky, Alexander J. Gates, Luis M. Rocha

We propose a method to decompose dynamical systems based on the idea that modules constrain the spread of perturbations.

Physics and Society Social and Information Networks Adaptation and Self-Organizing Systems Data Analysis, Statistics and Probability

Extraction of Pharmacokinetic Evidence of Drug-drug Interactions from the Literature

no code implementations2 Dec 2014 Artemy Kolchinsky, Anália Lourenço, Heng-Yi Wu, Lang Li, Luis M. Rocha

We used manually curated corpora of PubMed abstracts and annotated sentences to evaluate the efficacy of literature mining on two tasks: first, identifying PubMed abstracts containing pharmacokinetic evidence of DDIs; second, extracting sentences containing such evidence from abstracts.

Epidemiology General Classification +3

Prediction and Modularity in Dynamical Systems

no code implementations19 Jun 2011 Artemy Kolchinsky, Luis M. Rocha

Identifying and understanding modular organizations is centrally important in the study of complex systems.

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