Search Results for author: Mara Graziani

Found 11 papers, 9 papers with code

Structural-Based Uncertainty in Deep Learning Across Anatomical Scales: Analysis in White Matter Lesion Segmentation

1 code implementation15 Nov 2023 Nataliia Molchanova, Vatsal Raina, Andrey Malinin, Francesco La Rosa, Adrien Depeursinge, Mark Gales, Cristina Granziera, Henning Muller, Mara Graziani, Meritxell Bach Cuadra

The results from a multi-centric MRI dataset of 172 patients demonstrate that our proposed measures more effectively capture model errors at the lesion and patient scales compared to measures that average voxel-scale uncertainty values.

Lesion Segmentation Uncertainty Quantification

Uncovering Unique Concept Vectors through Latent Space Decomposition

no code implementations13 Jul 2023 Mara Graziani, Laura O' Mahony, An-phi Nguyen, Henning Müller, Vincent Andrearczyk

By decomposing the latent space of a layer in singular vectors and refining them by unsupervised clustering, we uncover concept vectors aligned with directions of high variance that are relevant to the model prediction, and that point to semantically distinct concepts.

Disentangling Neuron Representations with Concept Vectors

1 code implementation19 Apr 2023 Laura O'Mahony, Vincent Andrearczyk, Henning Muller, Mara Graziani

Mechanistic interpretability aims to understand how models store representations by breaking down neural networks into interpretable units.

Regression-based Deep-Learning predicts molecular biomarkers from pathology slides

1 code implementation11 Apr 2023 Omar S. M. El Nahhas, Chiara M. L. Loeffler, Zunamys I. Carrero, Marko van Treeck, Fiona R. Kolbinger, Katherine J. Hewitt, Hannah S. Muti, Mara Graziani, Qinghe Zeng, Julien Calderaro, Nadina Ortiz-Brüchle, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Alexander Brobeil, Jorge S. Reis-Filho, Jakob Nikolas Kather

We tested our method for multiple clinically and biologically relevant biomarkers: homologous repair deficiency (HRD) score, a clinically used pan-cancer biomarker, as well as markers of key biological processes in the tumor microenvironment.

Classification regression

Tackling Bias in the Dice Similarity Coefficient: Introducing nDSC for White Matter Lesion Segmentation

1 code implementation10 Feb 2023 Vatsal Raina, Nataliia Molchanova, Mara Graziani, Andrey Malinin, Henning Muller, Meritxell Bach Cuadra, Mark Gales

This work describes a detailed analysis of the recently proposed normalised Dice Similarity Coefficient (nDSC) for binary segmentation tasks as an adaptation of DSC which scales the precision at a fixed recall rate to tackle this bias.

Lesion Segmentation Segmentation

Attention-based Interpretable Regression of Gene Expression in Histology

1 code implementation29 Aug 2022 Mara Graziani, Niccolò Marini, Nicolas Deutschmann, Nikita Janakarajan, Henning Müller, María Rodríguez Martínez

Interpretability of deep learning is widely used to evaluate the reliability of medical imaging models and reduce the risks of inaccurate patient recommendations.

regression

Learning Interpretable Microscopic Features of Tumor by Multi-task Adversarial CNNs To Improve Generalization

1 code implementation4 Aug 2020 Mara Graziani, Sebastian Otalora, Stephane Marchand-Maillet, Henning Muller, Vincent Andrearczyk

Here we show that our architecture, by learning end-to-end an uncertainty-based weighting combination of multi-task and adversarial losses, is encouraged to focus on pathology features such as density and pleomorphism of nuclei, e. g. variations in size and appearance, while discarding misleading features such as staining differences.

Multi-Task Learning

Regression Concept Vectors for Bidirectional Explanations in Histopathology

1 code implementation9 Apr 2019 Mara Graziani, Vincent Andrearczyk, Henning Müller

Explanations for deep neural network predictions in terms of domain-related concepts can be valuable in medical applications, where justifications are important for confidence in the decision-making.

Breast Cancer Detection Decision Making +2

Studying the control of non invasive prosthetic hands over large time spans

no code implementations18 Nov 2015 Mara Graziani

The electromyography (EMG) signal is the electrical manifestation of a neuromuscular activation that provides access to physiological processes which cause the muscle to generate force and produce movement.

Electromyography (EMG) General Classification

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