no code implementations • 30 Oct 2023 • Sabrina Schönfeld, Laura Scarabosio, Alican Ozkan, Marissa Nichole Rylander, Christina Kuttler
Using a novel modeling approach based on the so-called environmental stress level (ESL), we develop a mathematical model to describe systematically the collective influence of oxygen concentration and stiffness of the extracellular matrix on the response of tumor cells to a combined chemotherapeutic treatment.
no code implementations • 17 Sep 2018 • Manasa Gadde, Caleb Phillips, Neda Ghousifam, Anna G. Sorace, Enoch Wong, Savitri Krishnamurthy, Anum Syed, Omar Rahal, Thomas E. Yankeelov, Wendy A. Woodward, Marissa Nichole Rylander
In this study, we developed the first three-dimensional, in vitro, vascularized, breast tumor platform to quantify the spatial and temporal dynamics of tumor-vasculature and tumor-ECM interactions specific to IBC.
