Search Results for author: Mark J. Van Der Laan

Found 26 papers, 8 papers with code

Nonparametric estimation of a covariate-adjusted counterfactual treatment regimen response curve

no code implementations28 Sep 2023 Ashkan Ertefaie, Luke Duttweiler, Brent A. Johnson, Mark J. Van Der Laan

Third, we provide consistency and convergence rate for the optimizer of the regimen-response curve estimator; this enables us to estimate an optimal semiparametric rule.

counterfactual

Multi-task Highly Adaptive Lasso

no code implementations27 Jan 2023 Ivana Malenica, Rachael V. Phillips, Daniel Lazzareschi, Jeremy R. Coyle, Romain Pirracchio, Mark J. Van Der Laan

We propose a novel, fully nonparametric approach for the multi-task learning, the Multi-task Highly Adaptive Lasso (MT-HAL).

Multi-Task Learning

Adaptive Sequential Surveillance with Network and Temporal Dependence

no code implementations5 Dec 2022 Ivana Malenica, Jeremy R. Coyle, Mark J. Van Der Laan, Maya L. Petersen

Our causal target parameter is the mean latent outcome we would have obtained after one time-step, if, starting at time t given the observed past, we had carried out a stochastic intervention that maximizes the outcome under a resource constraint.

Why Machine Learning Cannot Ignore Maximum Likelihood Estimation

no code implementations23 Oct 2021 Mark J. Van Der Laan, Sherri Rose

The growth of machine learning as a field has been accelerating with increasing interest and publications across fields, including statistics, but predominantly in computer science.

BIG-bench Machine Learning

Personalized Online Machine Learning

no code implementations21 Sep 2021 Ivana Malenica, Rachael V. Phillips, Romain Pirracchio, Antoine Chambaz, Alan Hubbard, Mark J. Van Der Laan

In this work, we introduce the Personalized Online Super Learner (POSL) -- an online ensembling algorithm for streaming data whose optimization procedure accommodates varying degrees of personalization.

BIG-bench Machine Learning Time Series +1

Adaptive Sequential Design for a Single Time-Series

no code implementations29 Jan 2021 Ivana Malenica, Aurelien Bibaut, Mark J. Van Der Laan

The current work is motivated by the need for robust statistical methods for precision medicine; as such, we address the need for statistical methods that provide actionable inference for a single unit at any point in time.

Time Series Time Series Analysis

Targeting Learning: Robust Statistics for Reproducible Research

no code implementations12 Jun 2020 Jeremy R. Coyle, Nima S. Hejazi, Ivana Malenica, Rachael V. Phillips, Benjamin F. Arnold, Andrew Mertens, Jade Benjamin-Chung, Weixin Cai, Sonali Dayal, John M. Colford Jr., Alan E. Hubbard, Mark J. Van Der Laan

Targeted Learning is a subfield of statistics that unifies advances in causal inference, machine learning and statistical theory to help answer scientifically impactful questions with statistical confidence.

Causal Inference Survival Analysis

Rate-adaptive model selection over a collection of black-box contextual bandit algorithms

no code implementations5 Jun 2020 Aurélien F. Bibaut, Antoine Chambaz, Mark J. Van Der Laan

To the best of our knowledge, our proposal is the first one to be rate-adaptive for a collection of general black-box contextual bandit algorithms: it achieves the same regret rate as the best candidate.

Model Selection

Nonparametric inverse probability weighted estimators based on the highly adaptive lasso

2 code implementations22 May 2020 Ashkan Ertefaie, Nima S. Hejazi, Mark J. Van Der Laan

We propose a class of nonparametric inverse probability weighted estimators in which the weighting mechanism is estimated via undersmoothing of the highly adaptive lasso, a nonparametric regression function proven to converge at $n^{-1/3}$-rate to the true weighting mechanism.

Efficient nonparametric inference on the effects of stochastic interventions under two-phase sampling, with applications to vaccine efficacy trials

3 code implementations30 Mar 2020 Nima S. Hejazi, Mark J. Van Der Laan, Holly E. Janes, Peter B. Gilbert, David C. Benkeser

We propose nonparametric methodology for efficiently estimating a counterfactual parameter that quantifies the impact of a given immune response marker on the subsequent probability of infection.

Methodology

Generalized Policy Elimination: an efficient algorithm for Nonparametric Contextual Bandits

no code implementations5 Mar 2020 Aurélien F. Bibaut, Antoine Chambaz, Mark J. Van Der Laan

We propose the Generalized Policy Elimination (GPE) algorithm, an oracle-efficient contextual bandit (CB) algorithm inspired by the Policy Elimination algorithm of \cite{dudik2011}.

Multi-Armed Bandits

More Efficient Off-Policy Evaluation through Regularized Targeted Learning

no code implementations13 Dec 2019 Aurélien F. Bibaut, Ivana Malenica, Nikos Vlassis, Mark J. Van Der Laan

We study the problem of off-policy evaluation (OPE) in Reinforcement Learning (RL), where the aim is to estimate the performance of a new policy given historical data that may have been generated by a different policy, or policies.

Causal Inference Off-policy evaluation

Statistical Analysis Plan for SEARCH Phase I: Health Outcomes among Adults

2 code implementations25 Jul 2018 Laura B. Balzer, Diane V. Havlir, Joshua Schwab, Mark J. Van Der Laan, Maya L. Petersen

This document provides the analytic plan for evaluating adult HIV incidence, health, and implementation outcomes for the first phase of the SEARCH Study.

Applications

Robust inference on the average treatment effect using the outcome highly adaptive lasso

no code implementations18 Jun 2018 Cheng Ju, David Benkeser, Mark J. Van Der Laan

Many estimators of the average effect of a treatment on an outcome require estimation of the propensity score, the outcome regression, or both.

regression

Collaborative targeted inference from continuously indexed nuisance parameter estimators

no code implementations31 Mar 2018 Cheng Ju, Antoine Chambaz, Mark J. Van Der Laan

Say that the above product is not fast enough and the algorithm for the $G$-component is fine-tuned by a real-valued $h$.

A generalization of moderated statistics to data adaptive semiparametric estimation in high-dimensional biology

1 code implementation16 Oct 2017 Nima S. Hejazi, Sara Kherad-Pajouh, Mark J. Van Der Laan, Alan E. Hubbard

The widespread availability of high-dimensional biological data has made the simultaneous screening of many biological characteristics a central problem in computational biology and allied sciences.

Methodology

On Adaptive Propensity Score Truncation in Causal Inference

1 code implementation18 Jul 2017 Cheng Ju, Joshua Schwab, Mark J. Van Der Laan

Even if the positivity assumption holds, practical violations of this assumption may jeopardize the finite sample performance of the causal estimator.

Causal Inference

Collaborative-controlled LASSO for Constructing Propensity Score-based Estimators in High-Dimensional Data

no code implementations30 Jun 2017 Cheng Ju, Richard Wyss, Jessica M. Franklin, Sebastian Schneeweiss, Jenny Häggström, Mark J. Van Der Laan

Collaborative minimum loss-based estimation (C-TMLE) is a novel methodology for causal inference that takes into account information on the causal parameter of interest when selecting a PS model.

Causal Inference Model Selection

A new approach to hierarchical data analysis: Targeted maximum likelihood estimation for the causal effect of a cluster-level exposure

no code implementations8 Jun 2017 Laura B. Balzer, Wenjing Zheng, Mark J. Van Der Laan, Maya L. Petersen

Incorporating working assumptions during estimation is more robust than assuming they hold in the underlying causal model.

Methodology

Targeted Learning with Daily EHR Data

no code implementations27 May 2017 Oleg Sofrygin, Zheng Zhu, Julie A Schmittdiel, Alyce S. Adams, Richard W. Grant, Mark J. Van Der Laan, Romain Neugebauer

Electronic health records (EHR) data provide a cost and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings.

Causal inference for social network data

1 code implementation23 May 2017 Elizabeth L. Ogburn, Oleg Sofrygin, Ivan Diaz, Mark J. Van Der Laan

We describe semiparametric estimation and inference for causal effects using observational data from a single social network.

Methodology Statistics Theory Statistics Theory

Sequential Double Robustness in Right-Censored Longitudinal Models

1 code implementation6 May 2017 Alexander R. Luedtke, Oleg Sofrygin, Mark J. Van Der Laan, Marco Carone

Consider estimating the G-formula for the counterfactual mean outcome under a given treatment regime in a longitudinal study.

Methodology

The Relative Performance of Ensemble Methods with Deep Convolutional Neural Networks for Image Classification

1 code implementation5 Apr 2017 Cheng Ju, Aurélien Bibaut, Mark J. Van Der Laan

In this work, we investigated multiple widely used ensemble methods, including unweighted averaging, majority voting, the Bayes Optimal Classifier, and the (discrete) Super Learner, for image recognition tasks, with deep neural networks as candidate algorithms.

General Classification Image Classification +3

An Omnibus Nonparametric Test of Equality in Distribution for Unknown Functions

no code implementations14 Oct 2015 Alexander R. Luedtke, Marco Carone, Mark J. Van Der Laan

We present a novel family of nonparametric omnibus tests of the hypothesis that two unknown but estimable functions are equal in distribution when applied to the observed data structure.

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