Search Results for author: Minghan Chen

Found 7 papers, 0 papers with code

Neural Symbolic Regression using Control Variables

no code implementations7 Jun 2023 Xieting Chu, Hongjue Zhao, Enze Xu, Hairong Qi, Minghan Chen, Huajie Shao

Experimental results demonstrate that the proposed SRCV significantly outperforms state-of-the-art baselines in discovering mathematical expressions with multiple variables.

regression Symbolic Regression

Pathology Steered Stratification Network for Subtype Identification in Alzheimer's Disease

no code implementations12 Oct 2022 Enze Xu, Jingwen Zhang, Jiadi Li, Qianqian Song, Defu Yang, Guorong Wu, Minghan Chen

Alzheimer's disease (AD) is a heterogeneous, multifactorial neurodegenerative disorder characterized by beta-amyloid, pathologic tau, and neurodegeneration.

Uncovering the dynamic effects of DEX treatment on lung cancer by integrating bioinformatic inference and multiscale modeling of scRNA-seq and proteomics data

no code implementations1 Mar 2022 Minghan Chen, Chunrui Xu, Ziang Xu, wei he, Haorui Zhang, Jing Su, Qianqian Song

Those genes involved in the TGF-\b{eta} pathway and their crosstalk with the ERBB pathway presented a strong survival prognosis in clinical lung cancer samples.

Time Series Analysis

Uncovering the System Vulnerability and Criticality of Human Brain under Dynamical Neuropathological Events in Alzheimer's Disease

no code implementations22 Jan 2022 Jingwen Zhang, Qing Liu, Haorui Zhang, Michelle Dai, Qianqian Song, Defu Yang, Guorong Wu, Minghan Chen

Background: Despite the striking efforts in investigating neurobiological factors behind the acquisition of amyloid-\b{eta} (A), protein tau (T), and neurodegeneration ([N]) biomarkers, the mechanistic pathways of how AT[N] biomarkers spreading throughout the brain remain elusive.

Analyzing the Spatiotemporal Interaction and Propagation of ATN Biomarkers in Alzheimer's Disease using Longitudinal Neuroimaging Data

no code implementations7 Mar 2021 Qing Liu, Defu Yang, Jingwen Zhang, Ziming Wei, Guorong Wu, Minghan Chen

Three major biomarkers: beta-amyloid (A), pathologic tau (T), and neurodegeneration (N), are recognized as valid proxies for neuropathologic changes of Alzheimer's disease.

valid

Finding Acceptable Parameter Regions of Stochastic Hill functions for Multisite Phosphorylation Mechanism

no code implementations14 Sep 2020 Minghan Chen, Mansooreh Ahmadian, Layne Watson, Yang Cao

To reduce model complexity, this work aims to simplify the multisite phosphorylation mechanism by a stochastic Hill function model.

Stochastic Optimization valid

A Network-Guided Reaction-Diffusion Model of AT[N] Biomarkers in Alzheimer's Disease

no code implementations10 Sep 2020 Jingwen Zhang, Defu Yang, wei he, Guorong Wu, Minghan Chen

Currently, many studies of Alzheimer's disease (AD) are investigating the neurobiological factors behind the acquisition of beta-amyloid (A), pathologic tau (T), and neurodegeneration ([N]) biomarkers from neuroimages.

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