Search Results for author: Nicholas Geard

Found 7 papers, 4 papers with code

A model-based assessment of social isolation practices for COVID-19 outbreak response in residential care facilities

1 code implementation29 Dec 2023 Cameron Zachreson, Ruarai Tobin, Camelia Walker, Eamon Conway, Freya M Shearer, Jodie McVernon, Nicholas Geard

We apply a computational modelling approach to investigate the relative effectiveness of general isolation practices for mitigation of COVID-19 outbreaks in residential care facilities.

AI driven B-cell Immunotherapy Design

no code implementations3 Sep 2023 Bruna Moreira da Silva, David B. Ascher, Nicholas Geard, Douglas E. V. Pires

Antibodies, a prominent class of approved biologics, play a crucial role in detecting foreign antigens.

Specificity

Correlation of viral loads in disease transmission chains could bias early estimates of the reproduction number

no code implementations16 Nov 2022 Thomas Harris, Nicholas Geard, Cameron Zachreson

Here, we use simulations to investigate a potential source of bias in such estimates, arising from correlations between the viral load of cases in transmission chains.

MPVNN: Mutated Pathway Visible Neural Network Architecture for Interpretable Prediction of Cancer-specific Survival Risk

1 code implementation2 Feb 2022 Gourab Ghosh Roy, Nicholas Geard, Karin Verspoor, Shan He

We show that trained MPVNN architecture interpretation, which points to smaller sets of genes connected by signal flow within the PI3K-Akt pathway that are important in risk prediction for particular cancer types, is reliable.

Survival Analysis

Modelling the effect of within-host dynamics on the diversity of a multi-strain pathogen

1 code implementation15 Nov 2021 Nefel Tellioglu, Nicholas Geard, Rebecca H. Chisholm

Currently, little data is available to validate these assumptions, hence there is a need to clarify how sensitive model outputs are to these assumptions.

COVID-19 in low-tolerance border quarantine systems: impact of the Delta variant of SARS-CoV-2

1 code implementation27 Sep 2021 Cameron Zachreson, Freya M. Shearer, David J. Price, Michael J. Lydeamore, Jodie McVernon, James McCaw, Nicholas Geard

We examine disease transmission and vaccine efficacy parameters over a wide range, covering plausible values for the Delta variant currently circulating globally.

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