1 code implementation • 29 Dec 2023 • Cameron Zachreson, Ruarai Tobin, Camelia Walker, Eamon Conway, Freya M Shearer, Jodie McVernon, Nicholas Geard
We apply a computational modelling approach to investigate the relative effectiveness of general isolation practices for mitigation of COVID-19 outbreaks in residential care facilities.
no code implementations • 3 Sep 2023 • Bruna Moreira da Silva, David B. Ascher, Nicholas Geard, Douglas E. V. Pires
Antibodies, a prominent class of approved biologics, play a crucial role in detecting foreign antigens.
no code implementations • 16 Nov 2022 • Thomas Harris, Nicholas Geard, Cameron Zachreson
Here, we use simulations to investigate a potential source of bias in such estimates, arising from correlations between the viral load of cases in transmission chains.
1 code implementation • 2 Feb 2022 • Gourab Ghosh Roy, Nicholas Geard, Karin Verspoor, Shan He
We show that trained MPVNN architecture interpretation, which points to smaller sets of genes connected by signal flow within the PI3K-Akt pathway that are important in risk prediction for particular cancer types, is reliable.
1 code implementation • 15 Nov 2021 • Nefel Tellioglu, Nicholas Geard, Rebecca H. Chisholm
Currently, little data is available to validate these assumptions, hence there is a need to clarify how sensitive model outputs are to these assumptions.
no code implementations • 11 Nov 2021 • Rebecca H. Chisholm, Jake A. Lacey, Jan Kokko, Patricia T. Campbell, Malcolm I. McDonald, Jukka Corander, Mark R. Davies, Steven Y. C. Tong, Jodie McVernon, Nicholas Geard
The bacterium Group A Streptococcus (Streptococcus pyogenes, GAS) is a human-specific pathogen and a major cause of global morbidity and mortality.
1 code implementation • 27 Sep 2021 • Cameron Zachreson, Freya M. Shearer, David J. Price, Michael J. Lydeamore, Jodie McVernon, James McCaw, Nicholas Geard
We examine disease transmission and vaccine efficacy parameters over a wide range, covering plausible values for the Delta variant currently circulating globally.