1 code implementation • 12 Jun 2023 • Justin G. Laughlin, Jørgen S. Dokken, Henrik N. T. Finsberg, Emmet A. Francis, Christopher T. Lee, Marie E. Rognes, Padmini Rangamani
Recent advances in microscopy and 3D reconstruction methods have allowed for characterization of cellular morphology in unprecedented detail, including the irregular geometries of intracellular subcompartments such as membrane-bound organelles.
no code implementations • 31 May 2023 • Yuzhu Chen, David Saintillan, Padmini Rangamani
We extended this model to 2D to study the interplay between cell shape and mechanics during crawling.
no code implementations • 10 Jun 2022 • Sage Malingen, Padmini Rangamani
The deformation of cellular membranes regulates trafficking processes, such as exocytosis and endocytosis.
1 code implementation • 11 Apr 2022 • Nathaniel J. Linden, Boris Kramer, Padmini Rangamani
In this study, we propose a comprehensive framework for Bayesian parameter estimation and complete quantification of the effects of uncertainties in the data and models.
no code implementations • 28 Jan 2021 • Debabrata Auddya, Xiaoxuan Zhang, Rahul Gulati, Ritvik Vasan, Krishna Garikipati, Padmini Rangamani, Shiva Rudraraju
Lipid bilayers are represented as spline-based surfaces immersed in a 3D space; this enables modeling of a wide spectrum of membrane geometries, boundary conditions, and deformations that are physically admissible in a 3D space.
no code implementations • 17 Sep 2020 • Lucas M. Stolerman, Pradipta Ghosh, Padmini Rangamani
GTPases are molecular switches that regulate a wide range of cellular processes, such as organelle biogenesis, position, shape, and signal transduction.
no code implementations • 20 Feb 2019 • Oleg Igoshin, Jing Chen, Jianhua Xing, Jian Liu, Timothy C. Elston, Michael Grabe, Kenneth S. Kim, Jasmine Nirody, Padmini Rangamani, Sean Sun, Hongyun Wang, Charles Wolgemuth
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry.