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Sex Differences in 6-Year Progression of White Matter Hyperintensities in Non-Demented Older Adults: Sydney Memory and Ageing Study
Conclusion: The findings highlighted sex differences in the associations between WMH progression and cognition decline over time, suggesting sex-specific strategies in managing WMH accumulations in ageing.
Temporal Pattern Mining for Analysis of Longitudinal Clinical Data: Identifying Risk Factors for Alzheimer's Disease
This method uses temporal abstraction to convert the data into a more appropriate form for modelling, temporal pattern mining, to discover patterns in the complex, longitudinal data and machine learning models of survival analysis to select the discovered patterns.
Ensemble feature selection with clustering for analysis of high-dimensional, correlated clinical data in the search for Alzheimer's disease biomarkers
When feature selection is applied to these datasets to identify the most important features, the biases inherent in some multivariate feature selectors due to correlated features make it difficult for these methods to distinguish between the important and irrelevant features and the results of the feature selection process can be unstable.
Ensemble feature selection with data-driven thresholding for Alzheimer's disease biomarker discovery
A fixed threshold, which is typically applied, offers no guarantee that the final set of selected features contains only relevant features.
Hormonal Factors Moderate the Associations Between Vascular Risk Factors and White Matter Hyperintensities
Generalised linear models were applied to examine 1) the main effects of vascular (body mass index, hip to waist ratio, pulse wave velocity, hypercholesterolemia, diabetes, hypertension, smoking status) and hormonal (testosterone levels, contraceptive pill, hormone replacement therapy, menopause) factors on WMH, and 2) the moderation effects of hormonal factors on the relationship between vascular risk factors and WMH volumes.
Computer-Aided Extraction of Select MRI Markers of Cerebral Small Vessel Disease: A Systematic Review
Cerebral small vessel disease (CSVD) is a major vascular contributor to cognitive impairment in ageing, including dementias.
