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The Biological Data Sustainability Paradox
Biological data in digital form has become a, if not the, driving force behind innovations in biology, medicine, and the environment.
Exploration of Dark Chemical Genomics Space via Portal Learning: Applied to Targeting the Undruggable Genome and COVID-19 Anti-Infective Polypharmacology
Advances in biomedicine are largely fueled by exploring uncharted territories of human biology.
Advance in Reversible Covalent Kinase Inhibitors
Finally, we provide a brief perspective on future design strategies for RCKIs, including those that target proteins other than kinases.
Using the structural kinome to systematize kinase drug discovery
Thus, obtaining the desired selectivity, given the whole human kinome, is a fundamental task during early-stage drug discovery.
A Birds-eye (Re)View of Acid-suppression Drugs, COVID-19, and the Highly Variable Literature
We consider the recent surge of information on the potential benefits of acid-suppression drugs in the context of COVID-19, with an eye on the variability (and confusion) across the reported findings--at least as regards the popular antacid famotidine.
Machine Learning for Classification of Protein Helix Capping Motifs
The biological function of a protein stems from its 3-dimensional structure, which is thermodynamically determined by the energetics of interatomic forces between its amino acid building blocks (the order of amino acids, known as the sequence, defines a protein).
Ten Simple Rules When Considering Retirement
This is an article submitted to the Ten Simple Rules series of professional development articles published by PLOS Computational Biology.
