Search Results for author: Philippe Lemey

Found 8 papers, 6 papers with code

On the importance of assessing topological convergence in Bayesian phylogenetic inference

no code implementations18 Feb 2024 Marius Brusselmans, Luiz Max Carvalho, Samuel L. Hong, Jiansi Gao, Frederick A. Matsen IV, Andrew Rambaut, Philippe Lemey, Marc A. Suchard, Gytis Dudas, Guy Baele

Modern phylogenetics research is often performed within a Bayesian framework, using sampling algorithms such as Markov chain Monte Carlo (MCMC) to approximate the posterior distribution.

Scalable Bayesian divergence time estimation with ratio transformations

1 code implementation25 Oct 2021 Xiang Ji, Alexander A. Fisher, Shuo Su, Jeffrey L. Thorne, Barney Potter, Philippe Lemey, Guy Baele, Marc A. Suchard

Divergence time estimation is crucial to provide temporal signals for dating biologically important events, from species divergence to viral transmissions in space and time.

Principled, practical, flexible, fast: a new approach to phylogenetic factor analysis

2 code implementations2 Jul 2021 Gabriel W. Hassler, Brigida Gallone, Leandro Aristide, William L. Allen, Max R. Tolkoff, Andrew J. Holbrook, Guy Baele, Philippe Lemey, Marc A. Suchard

Even in the presence of non-trivial phylogenetic model constraints, we show that one may analytically address latent factor uncertainty in a way that (a) aids model flexibility, (b) accelerates computation (by as much as 500-fold) and (c) decreases required tuning.

Deep reinforcement learning for large-scale epidemic control

1 code implementation30 Mar 2020 Pieter Libin, Arno Moonens, Timothy Verstraeten, Fabian Perez-Sanjines, Niel Hens, Philippe Lemey, Ann Nowé

For this reason, we investigate a deep reinforcement learning approach to automatically learn prevention strategies in the context of pandemic influenza.

Computational Efficiency reinforcement-learning +1

Gradients do grow on trees: a linear-time ${\cal O}\hspace{-0.2em}\left( N \right)$-dimensional gradient for statistical phylogenetics

1 code implementation29 May 2019 Xiang Ji, Zhen-Yu Zhang, Andrew Holbrook, Akihiko Nishimura, Guy Baele, Andrew Rambaut, Philippe Lemey, Marc A. Suchard

To make this tractable, we present a linear-time algorithm for ${\cal O}\hspace{-0. 2em}\left( N \right)$-dimensional gradient evaluation and apply it to general continuous-time Markov processes of sequence substitution on a phylogenetic tree without a need to assume either stationarity or reversibility.

Computation Populations and Evolution Methodology

Bayesian Best-Arm Identification for Selecting Influenza Mitigation Strategies

no code implementations16 Nov 2017 Pieter Libin, Timothy Verstraeten, Diederik M. Roijers, Jelena Grujic, Kristof Theys, Philippe Lemey, Ann Nowé

We evaluate these algorithms in a realistic experimental setting and demonstrate that it is possible to identify the optimal strategy using only a limited number of model evaluations, i. e., 2-to-3 times faster compared to the uniform sampling method, the predominant technique used for epidemiological decision making in the literature.

Decision Making Thompson Sampling

Spatio-temporal Dynamics of Foot-and-Mouth Disease Virus in South America

1 code implementation5 May 2015 Luiz Max Carvalho, Nuno Rodrigues Faria, Andres M. Perez, Marc A. Suchard, Philippe Lemey, Waldemir de Castro Silveira, Andrew Rambaut, Guy Baele

Although foot-and-mouth disease virus (FMDV) incidence has decreased in South America over the last years, the pathogen still circulates in the region and the risk of re-emergence in previously FMDV-free areas is a veterinary public health concern.

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