no code implementations • 11 Jan 2024 • Qiao Lu, Simone Pigolotti
We solve our model, obtaining an expression for the average search time of Cas9 for its target.
no code implementations • 24 Aug 2023 • Florian Pflug, Deepak Bhat, Simone Pigolotti
In this paper, we predict the abundance of DNA fragments in asynchronously growing cultures from any given stochastic model of the DNA replication program.
no code implementations • 10 Apr 2022 • Paula Villa Martin, Anzhelika Koldaeva, Simone Pigolotti
The dynamics of these rare species is best described by individual-based models.
no code implementations • 9 Apr 2021 • Anzhelika Koldaeva, Hsieh-Fu Tsai, Amy Q. Shen, Simone Pigolotti
Our analysis is based on a population model in which reproducing cells shift entire lanes of cells towards the open ends of the channel.
no code implementations • 19 Mar 2021 • Qiao Lu, Deepak Bhat, Darya Stepanenko, Simone Pigolotti
The role of Cas9 is to search for specific target sequences on the DNA and cleave them.
no code implementations • 7 Jan 2021 • Simone Pigolotti
If fluctuations are uncorrelated among different cells, the population growth rate is predicted by the Euler-Lotka equation, which is a classic result in mathematical biology.
no code implementations • 28 Jun 2019 • Simone Pigolotti, Mogens H. Jensen, Yinxiu Zhan, Guido Tiana
In this paper, we introduce a multifractal analysis of chromosomal contact maps.
no code implementations • 30 May 2019 • Davide Chiuchiú, Yuhai Tu, Simone Pigolotti
In this paper, we study fluctuations of error and speed in biopolymer synthesis and show that they are in general correlated.