Search Results for author: Simone Pigolotti

Found 8 papers, 0 papers with code

Target search in the CRISPR/Cas9 system: Facilitated diffusion with target cues

no code implementations11 Jan 2024 Qiao Lu, Simone Pigolotti

We solve our model, obtaining an expression for the average search time of Cas9 for its target.

Genome replication in asynchronously growing microbial populations

no code implementations24 Aug 2023 Florian Pflug, Deepak Bhat, Simone Pigolotti

In this paper, we predict the abundance of DNA fragments in asynchronously growing cultures from any given stochastic model of the DNA replication program.

Coalescent dynamics of planktonic communities

no code implementations10 Apr 2022 Paula Villa Martin, Anzhelika Koldaeva, Simone Pigolotti

The dynamics of these rare species is best described by individual-based models.

Population genetics in microchannels

no code implementations9 Apr 2021 Anzhelika Koldaeva, Hsieh-Fu Tsai, Amy Q. Shen, Simone Pigolotti

Our analysis is based on a population model in which reproducing cells shift entire lanes of cells towards the open ends of the channel.

Search and localization dynamics of the CRISPR/Cas9 system

no code implementations19 Mar 2021 Qiao Lu, Deepak Bhat, Darya Stepanenko, Simone Pigolotti

The role of Cas9 is to search for specific target sequences on the DNA and cleave them.

Generalized Euler-Lotka equation for correlated cell divisions

no code implementations7 Jan 2021 Simone Pigolotti

If fluctuations are uncorrelated among different cells, the population growth rate is predicted by the Euler-Lotka equation, which is a classic result in mathematical biology.

valid

Bifractal nature of chromosome contact maps

no code implementations28 Jun 2019 Simone Pigolotti, Mogens H. Jensen, Yinxiu Zhan, Guido Tiana

In this paper, we introduce a multifractal analysis of chromosomal contact maps.

Error-speed correlations in biopolymer synthesis

no code implementations30 May 2019 Davide Chiuchiú, Yuhai Tu, Simone Pigolotti

In this paper, we study fluctuations of error and speed in biopolymer synthesis and show that they are in general correlated.

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