Search Results for author: Thomas A. Lasko

Found 16 papers, 6 papers with code

Unsupervised Discovery of Clinical Disease Signatures Using Probabilistic Independence

no code implementations8 Feb 2024 Thomas A. Lasko, John M. Still, Thomas Z. Li, Marco Barbero Mota, William W. Stead, Eric V. Strobl, Bennett A. Landman, Fabien Maldonado

Insufficiently precise diagnosis of clinical disease is likely responsible for many treatment failures, even for common conditions and treatments.

Why Do Probabilistic Clinical Models Fail To Transport Between Sites?

no code implementations8 Nov 2023 Thomas A. Lasko, Eric V. Strobl, William W. Stead

The rising popularity of artificial intelligence in healthcare is highlighting the problem that a computational model achieving super-human clinical performance at its training sites may perform substantially worse at new sites.

Sample-Specific Root Causal Inference with Latent Variables

no code implementations27 Oct 2022 Eric V. Strobl, Thomas A. Lasko

Root causal analysis seeks to identify the set of initial perturbations that induce an unwanted outcome.

Causal Inference

UNesT: Local Spatial Representation Learning with Hierarchical Transformer for Efficient Medical Segmentation

1 code implementation28 Sep 2022 Xin Yu, Qi Yang, Yinchi Zhou, Leon Y. Cai, Riqiang Gao, Ho Hin Lee, Thomas Li, Shunxing Bao, Zhoubing Xu, Thomas A. Lasko, Richard G. Abramson, Zizhao Zhang, Yuankai Huo, Bennett A. Landman, Yucheng Tang

Transformer-based models, capable of learning better global dependencies, have recently demonstrated exceptional representation learning capabilities in computer vision and medical image analysis.

Brain Segmentation Image Segmentation +3

Time-distance vision transformers in lung cancer diagnosis from longitudinal computed tomography

1 code implementation4 Sep 2022 Thomas Z. Li, Kaiwen Xu, Riqiang Gao, Yucheng Tang, Thomas A. Lasko, Fabien Maldonado, Kim Sandler, Bennett A. Landman

In cross-validation on screening chest CTs from the NLST, our methods (0. 785 and 0. 786 AUC respectively) significantly outperform a cross-sectional approach (0. 734 AUC) and match the discriminative performance of the leading longitudinal medical imaging algorithm (0. 779 AUC) on benign versus malignant classification.

Lung Cancer Diagnosis Time Series Analysis

Identifying Patient-Specific Root Causes with the Heteroscedastic Noise Model

no code implementations25 May 2022 Eric V. Strobl, Thomas A. Lasko

Complex diseases are caused by a multitude of factors that may differ between patients even within the same diagnostic category.

Causal Inference

Identifying Patient-Specific Root Causes of Disease

1 code implementation23 May 2022 Eric V. Strobl, Thomas A. Lasko

Complex diseases are caused by a multitude of factors that may differ between patients.

Causal Inference

Characterizing Renal Structures with 3D Block Aggregate Transformers

no code implementations4 Mar 2022 Xin Yu, Yucheng Tang, Yinchi Zhou, Riqiang Gao, Qi Yang, Ho Hin Lee, Thomas Li, Shunxing Bao, Yuankai Huo, Zhoubing Xu, Thomas A. Lasko, Richard G. Abramson, Bennett A. Landman

Efficiently quantifying renal structures can provide distinct spatial context and facilitate biomarker discovery for kidney morphology.

Generalizing Clinical Trials with Convex Hulls

1 code implementation25 Nov 2021 Eric V. Strobl, Thomas A. Lasko

This assumption allows us to extrapolate results from exclusive trials to the broader population by analyzing observational and trial data simultaneously using an algorithm called Optimum in Convex Hulls (OCH).

Lung Cancer Risk Estimation with Incomplete Data: A Joint Missing Imputation Perspective

no code implementations25 Jul 2021 Riqiang Gao, Yucheng Tang, Kaiwen Xu, Ho Hin Lee, Steve Deppen, Kim Sandler, Pierre Massion, Thomas A. Lasko, Yuankai Huo, Bennett A. Landman

To our knowledge, it is the first generative adversarial model that addresses multi-modal missing imputation by modeling the joint distribution of image and non-image data.

Imputation

Synthesized Difference in Differences

no code implementations2 May 2021 Eric V. Strobl, Thomas A. Lasko

We instead propose Synthesized Difference in Differences (SDD) that infers the correct (possibly non-parallel) slopes by linearly adjusting a conditional version of DD using additional RCT data.

Selection bias

The Value of Nullspace Tuning Using Partial Label Information

no code implementations17 Mar 2020 Colin B. Hansen, Vishwesh Nath, Diego A. Mesa, Yuankai Huo, Bennett A. Landman, Thomas A. Lasko

But in some learning problems, partial label information can be inferred from otherwise unlabeled examples and used to further improve the model.

Fully Automatic Liver Attenuation Estimation Combing CNN Segmentation and Morphological Operations

1 code implementation23 Jun 2019 Yuankai Huo, James G. Terry, Jiachen Wang, Sangeeta Nair, Thomas A. Lasko, Barry I. Freedman, J. Jeffery Carr, Bennett A. Landman

Manually tracing regions of interest (ROIs) within the liver is the de facto standard method for measuring liver attenuation on computed tomography (CT) in diagnosing nonalcoholic fatty liver disease (NAFLD).

Computed Tomography (CT) Liver Segmentation +1

Efficient Inference of Gaussian Process Modulated Renewal Processes with Application to Medical Event Data

no code implementations19 Feb 2014 Thomas A. Lasko

Finally, we apply the method to clinical event data and demonstrate the face-validity of the abstraction, which is now amenable to standard learning algorithms.

Gaussian Processes

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