Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity

2 code implementations • 21 Apr 2020 • He Zhang, Liang Zhang, Ang Lin, Congcong Xu, Ziyu Li, Kaibo Liu, Boxiang Liu, Xiaopin Ma, Fanfan Zhao, Weiguo Yao, Hangwen Li, David H. Mathews, Yujian Zhang, Liang Huang

Messenger RNA (mRNA) vaccines are being used for COVID-19, but still suffer from the critical issue of mRNA instability and degradation, which is a major obstacle in the storage, distribution, and efficacy of the vaccine.

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