no code implementations • 9 Dec 2020 • Caner Mercan, Maschenka Balkenhol, Roberto Salgado, Mark Sherman, Philippe Vielh, Willem Vreuls, Antonio Polonia, Hugo M. Horlings, Wilko Weichert, Jodi M. Carter, Peter Bult, Matthias Christgen, Carsten Denkert, Koen van de Vijver, Jeroen van der Laak, Francesco Ciompi
Nuclear pleomorphism, defined herein as the extent of abnormalities in the overall appearance of tumor nuclei, is one of the components of the three-tiered breast cancer grading.
no code implementations • 17 Aug 2018 • David Tellez, Maschenka Balkenhol, Irene Otte-Holler, Rob van de Loo, Rob Vogels, Peter Bult, Carla Wauters, Willem Vreuls, Suzanne Mol, Nico Karssemeijer, Geert Litjens, Jeroen van der Laak, Francesco Ciompi
Application of CNNs to hematoxylin and eosin (H&E) stained histological tissue sections is hampered by: (1) noisy and expensive reference standards established by pathologists, (2) lack of generalization due to staining variation across laboratories, and (3) high computational requirements needed to process gigapixel whole-slide images (WSIs).