Search Results for author: William Bialek

Found 16 papers, 4 papers with code

Finding the last bits of positional information

no code implementations10 Dec 2023 Lauren McGough, Helena Casademunt, Miloš Nikolić, Mariela D. Petkova, Thomas Gregor, William Bialek

In a developing embryo, information about the position of cells is encoded in the concentrations of "morphogen" molecules.

Position

Long time scales, individual differences, and scale invariance in animal behavior

no code implementations19 Apr 2023 William Bialek, Joshua W. Shaevitz

The explosion of data on animal behavior in more natural contexts highlights the fact that these behaviors exhibit correlations across many time scales.

How different are self and nonself?

no code implementations22 Dec 2022 Andreas Mayer, Christopher J. Russo, Quentin Marcou, William Bialek, Benjamin D. Greenbaum

Biological and artificial neural networks routinely make reliable distinctions between similar inputs, and the rules for making these distinctions are learned.

Compression as a path to simplification: Models of collective neural activity

no code implementations28 Dec 2021 Luisa Ramirez, William Bialek

Patterns of activity in networks of neurons are a prototypical complex system.

Transcription-dependent spatial organization of a gene locus

no code implementations31 Dec 2020 Lev Barinov, Sergey Ryabichko, William Bialek, Thomas Gregor

There is growing appreciation that gene function is connected to the dynamic structure of the chromosome.

Trading bits in the readout from a genetic network

no code implementations31 Dec 2020 Marianne Bauer, Mariela D. Petkova, Thomas Gregor, Eric F. Wieschaus, William Bialek

We argue that cells in the embryo can extract all the available information about their position, but only if the concentration measurements approach the physical limits to information capacity.

Position

Exploring a strongly non-Markovian animal behavior

no code implementations31 Dec 2020 Vasyl Alba, Gordon J. Berman, William Bialek, Joshua W. Shaevitz

A freely walking fly visits roughly 100 stereotyped states in a strongly non-Markovian sequence.

Information costs in the control of protein synthesis

no code implementations30 Dec 2019 Rebecca J. Rousseau, William Bialek

Efficient protein synthesis depends on the availability of charged tRNA molecules.

Action at a distance in transcriptional regulation

no code implementations18 Dec 2019 William Bialek, Thomas Gregor, Gašper Tkačik

There is increasing evidence that protein binding to specific sites along DNA can activate the reading out of genetic information without coming into direct physical contact with the gene.

Mapping the stereotyped behaviour of freely-moving fruit flies

1 code implementation16 Oct 2013 Gordon J. Berman, Daniel M. Choi, William Bialek, Joshua W. Shaevitz

Most animals possess the ability to actuate a vast diversity of movements, ostensibly constrained only by morphology and physics.

Are biological systems poised at criticality?

no code implementations10 Dec 2010 Thierry Mora, William Bialek

Many of life's most fascinating phenomena emerge from interactions among many elements--many amino acids determine the structure of a single protein, many genes determine the fate of a cell, many neurons are involved in shaping our thoughts and memories.

Faster solutions of the inverse pairwise Ising problem

1 code implementation14 Dec 2007 Tamara Broderick, Miroslav Dudik, Gasper Tkacik, Robert E. Schapire, William Bialek

Recent work has shown that probabilistic models based on pairwise interactions-in the simplest case, the Ising model-provide surprisingly accurate descriptions of experiments on real biological networks ranging from neurons to genes.

Entropy and inference, revisited

1 code implementation15 Aug 2001 Ilya Nemenman, Fariel Shafee, William Bialek

We study properties of popular near-uniform (Dirichlet) priors for learning undersampled probability distributions on discrete nonmetric spaces and show that they lead to disastrous results.

Data Analysis, Statistics and Probability

The information bottleneck method

3 code implementations24 Apr 2000 Naftali Tishby, Fernando C. Pereira, William Bialek

We define the relevant information in a signal $x\in X$ as being the information that this signal provides about another signal $y\in \Y$.

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