no code implementations • 29 Dec 2023 • Miloš Nikolić, Victoria Antonetti, Feng Liu, Gentian Muhaxheri, Mariela D. Petkova, Martin Scheeler, Eric M. Smith, William Bialek, Thomas Gregor
The body plan of the fruit fly is determined by the expression of just a handful of genes.
no code implementations • 10 Dec 2023 • Lauren McGough, Helena Casademunt, Miloš Nikolić, Mariela D. Petkova, Thomas Gregor, William Bialek
In a developing embryo, information about the position of cells is encoded in the concentrations of "morphogen" molecules.
no code implementations • 19 Apr 2023 • William Bialek, Joshua W. Shaevitz
The explosion of data on animal behavior in more natural contexts highlights the fact that these behaviors exhibit correlations across many time scales.
no code implementations • 22 Dec 2022 • Andreas Mayer, Christopher J. Russo, Quentin Marcou, William Bialek, Benjamin D. Greenbaum
Biological and artificial neural networks routinely make reliable distinctions between similar inputs, and the rules for making these distinctions are learned.
no code implementations • 28 Dec 2021 • Luisa Ramirez, William Bialek
Patterns of activity in networks of neurons are a prototypical complex system.
no code implementations • 31 Dec 2020 • Lev Barinov, Sergey Ryabichko, William Bialek, Thomas Gregor
There is growing appreciation that gene function is connected to the dynamic structure of the chromosome.
no code implementations • 31 Dec 2020 • Marianne Bauer, Mariela D. Petkova, Thomas Gregor, Eric F. Wieschaus, William Bialek
We argue that cells in the embryo can extract all the available information about their position, but only if the concentration measurements approach the physical limits to information capacity.
no code implementations • 31 Dec 2020 • Vasyl Alba, Gordon J. Berman, William Bialek, Joshua W. Shaevitz
A freely walking fly visits roughly 100 stereotyped states in a strongly non-Markovian sequence.
no code implementations • 30 Dec 2019 • Rebecca J. Rousseau, William Bialek
Efficient protein synthesis depends on the availability of charged tRNA molecules.
no code implementations • 18 Dec 2019 • William Bialek, Thomas Gregor, Gašper Tkačik
There is increasing evidence that protein binding to specific sites along DNA can activate the reading out of genetic information without coming into direct physical contact with the gene.
1 code implementation • 16 Oct 2013 • Gordon J. Berman, Daniel M. Choi, William Bialek, Joshua W. Shaevitz
Most animals possess the ability to actuate a vast diversity of movements, ostensibly constrained only by morphology and physics.
no code implementations • 10 Dec 2010 • Thierry Mora, William Bialek
Many of life's most fascinating phenomena emerge from interactions among many elements--many amino acids determine the structure of a single protein, many genes determine the fate of a cell, many neurons are involved in shaping our thoughts and memories.
no code implementations • 28 Dec 2007 • William Bialek, Rob R. de Ruyter van Steveninck, Naftali Tishby
Does the brain construct an efficient representation of the sensory world?
1 code implementation • 14 Dec 2007 • Tamara Broderick, Miroslav Dudik, Gasper Tkacik, Robert E. Schapire, William Bialek
Recent work has shown that probabilistic models based on pairwise interactions-in the simplest case, the Ising model-provide surprisingly accurate descriptions of experiments on real biological networks ranging from neurons to genes.
1 code implementation • 15 Aug 2001 • Ilya Nemenman, Fariel Shafee, William Bialek
We study properties of popular near-uniform (Dirichlet) priors for learning undersampled probability distributions on discrete nonmetric spaces and show that they lead to disastrous results.
Data Analysis, Statistics and Probability
3 code implementations • 24 Apr 2000 • Naftali Tishby, Fernando C. Pereira, William Bialek
We define the relevant information in a signal $x\in X$ as being the information that this signal provides about another signal $y\in \Y$.