Search Results for author: Yasushi Okuno

Found 7 papers, 1 papers with code

GraphIX: Graph-based In silico XAI(explainable artificial intelligence) for drug repositioning from biopharmaceutical network

no code implementations21 Dec 2022 Atsuko Takagi, Mayumi Kamada, Eri Hamatani, Ryosuke Kojima, Yasushi Okuno

GraphIX is a framework for evidence-based drug discovery that can present to users new disease-drug associations and identify the protein important for understanding its pharmacological effects from a large and complex knowledge base.

Drug Discovery Explainable artificial intelligence +1

Individual health-disease phase diagrams for disease prevention based on machine learning

no code implementations31 May 2022 Kazuki Nakamura, Eiichiro Uchino, Noriaki Sato, Ayano Araki, Kei Terayama, Ryosuke Kojima, Koichi Murashita, Ken Itoh, Tatsuya Mikami, Yoshinori Tamada, Yasushi Okuno

Here, we present the health-disease phase diagram (HDPD), which represents a personal health state by visualizing the boundary values of multiple biomarkers that fluctuate early in the disease progression process.

BIG-bench Machine Learning Disease Prediction

Health improvement framework for planning actionable treatment process using surrogate Bayesian model

no code implementations30 Oct 2020 Kazuki Nakamura, Ryosuke Kojima, Eiichiro Uchino, Koichi Murashita, Ken Itoh, Shigeyuki Nakaji, Yasushi Okuno

A key point of the framework is the evaluation of the "actionability" for personal health improvements by using a surrogate Bayesian model in addition to a high-performance nonlinear ML model.

Clinical Knowledge Decision Making +1

Efficient Construction Method for Phase Diagrams Using Uncertainty Sampling

1 code implementation6 Dec 2018 Kei Terayama, Ryo Tamura, Yoshitaro Nose, Hidenori Hiramatsu, Hideo Hosono, Yasushi Okuno, Koji Tsuda

Furthermore, we show that using the US approach, undetected new phase can be rapidly found, and smaller number of initial sampling points are sufficient.

Materials Science Computational Physics

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