A novel framework to quantify uncertainty in peptide-tandem mass spectrum matches with application to nanobody peptide identification

no code implementations • 15 Oct 2021 • Chris McKennan, Zhe Sang, Yi Shi

To address these issues, we then develop a novel framework and method that treats peptide-spectrum matching as a Bayesian model selection problem with an incomplete model space, which are, to our knowledge, the first to account for all sources of PSM error without relying on the aforementioned assumptions.

Model Selection