input question: Extract the answer to the question from the following context. Question: Why does this process need to be completed before going to market? Context: In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.???
output answer: products must be approved by the Food and Drug Administration (FDA) as being both safe and effective

input question: Extract the answer to the question from the following context. Question: Why was Brahms' piece was cited? Context: Classical music has often incorporated elements or material from popular music of the composer's time. Examples include occasional music such as Brahms' use of student drinking songs in his Academic Festival Overture, genres exemplified by Kurt Weill's The Threepenny Opera, and the influence of jazz on early- and mid-20th-century composers including Maurice Ravel, exemplified by the movement entitled "Blues" in his sonata for violin and piano. Certain postmodern, minimalist and postminimalist classical composers acknowledge a debt to popular music.???
output answer: use of student drinking songs

input question: Extract the answer to the question from the following context. Question: Though popular, what songs didn't make #1 on the Hot 100? Context: In June 1986, Madonna released her third studio album, True Blue, which was inspired by and dedicated to Sean Penn. Rolling Stone magazine was generally impressed with the effort, writing that the album "sound[s] as if it comes from the heart". It resulted in three singles making it to number-one on the Billboard Hot 100: "Live to Tell", "Papa Don't Preach" and "Open Your Heart", and two more top-five singles: "True Blue" and "La Isla Bonita". The album topped the charts in over 28 countries worldwide, an unprecedented achievement at the time, and became her best-selling studio album of her career to this date with sales of 25 million. In the same year, Madonna starred in the critically panned film Shanghai Surprise, for which she was awarded the Golden Raspberry Award for "worst actress". She made her theatrical debut in a production of David Rabe's Goose and Tom-Tom; the film and play both co-starred Penn. The next year, Madonna was featured in the film Who's That Girl. She contributed four songs to its soundtrack, including the title track and "Causing a Commotion".???
output answer: "True Blue" and "La Isla Bonita"

input question: Extract the answer to the question from the following context. Question: Where did Mr. McVeigh attack? Context: On April 19, 1995, the Alfred P. Murrah Federal Building was destroyed by a fertilizer bomb manufactured and detonated by Timothy McVeigh. The blast and catastrophic collapse killed 168 people and injured over 680. The blast shockwave destroyed or damaged 324 buildings within a 340-meter radius, destroyed or burned 86 cars, and shattered glass in 258 nearby buildings, causing at least an estimated $652 million worth of damage. The main suspect- Timothy McVeigh, was executed by lethal injection on June 11, 2001. It was the deadliest single domestic terrorist attack in US history, prior to 9/11.???
output answer:
US