input question: Extract the answer to the question from the following context. Question: How do the trials occur? Context: In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.???
output answer: Following IND approval, three phases of progressively larger human clinical trials may be conducted

input question: Extract the answer to the question from the following context. Question: who is the second leader mentioned? Context: The Russian army withdrew and retreated past Moscow. Napoleon entered the city, assuming its fall would end the war and Alexander would negotiate peace. However, on orders of the city's governor Feodor Rostopchin, rather than capitulation, Moscow was burned. After five weeks, Napoleon and his army left. In early November Napoleon got concerned about loss of control back in France after the Malet coup of 1812. His army walked through snow up to their knees and nearly 10,000 men and horses froze to death on the night of 8/9 November alone. After Battle of Berezina Napoleon succeeded to escape but had to abandon much of the remaining artillery and baggage train. On 5 December, shortly before arriving in Vilnius, Napoleon left the army in a sledge.???
output answer: Alexander

input question: Extract the answer to the question from the following context. Question: Besides formal institutions, where else do soldiers acquire knowledge? Context: Canada's Armed forces operate out of 27 Canadian Forces bases (CFB) across the country, including NDHQ. This number has been gradually reduced since the 1970s with bases either being closed or merged. Both officers and non-commissioned members receive their basic training at the Canadian Forces Leadership and Recruit School in Saint-Jean-sur-Richelieu. Officers will generally either directly enter the Canadian Armed Forces with a degree from a civilian university, or receive their commission upon graduation from the Royal Military College of Canada. Specific element and trade training is conducted at a variety of institutions throughout Canada, and to a lesser extent, the world.???
output answer: Specific element and trade training is conducted at a variety of institutions throughout Canada, and to a lesser extent, the world

input question: Extract the answer to the question from the following context. Question: Which of the following is always present in invetebrates, a nerve or a brain? Context: The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. Only a few invertebrates such as sponges, jellyfish, adult sea squirts and starfish do not have a brain; diffuse or localised nerve nets are present instead. The brain is located in the head, usually close to the primary sensory organs for such senses as vision, hearing, balance, taste, and smell. The brain is the most complex organ in a vertebrate's body. In a typical human, the cerebral cortex (the largest part) is estimated to contain 15–33 billion neurons, each connected by synapses to several thousand other neurons. These neurons communicate with one another by means of long protoplasmic fibers called axons, which carry trains of signal pulses called action potentials to distant parts of the brain or body targeting specific recipient cells.???
output answer:
nerve