Detailed Instructions: In this task, you are given a question and a context passage. You have to answer the question based on the given passage.
Problem:How does DNA and RNA contact?, Context: Additionally, genes can have regulatory regions many kilobases upstream or downstream of the open reading frame. These act by binding to transcription factors which then cause the DNA to loop so that the regulatory sequence (and bound transcription factor) become close to the RNA polymerase binding site. For example, enhancers increase transcription by binding an activator protein which then helps to recruit the RNA polymerase to the promoter; conversely silencers bind repressor proteins and make the DNA less available for RNA polymerase.
Solution:
polymerase binding site