Teacher:In this task, you are given a question and a context passage. You have to answer the question based on the given passage.
Teacher: Now, understand the problem? Solve this instance: How severe can shift work be when referring to its potential effect on humans?, Context: Shift-work or chronic jet-lag have profound consequences on circadian and metabolic events in the body. Animals that are forced to eat during their resting period show increased body mass and altered expression of clock and metabolic genes.[medical citation needed] In humans, shift-work that favors irregular eating times is associated with altered insulin sensitivity and higher body mass. Shift-work also leads to increased metabolic risks for cardio-metabolic syndrome, hypertension, inflammation.
Student:
profound