In this task, you are given a question and a context passage. You have to answer the question based on the given passage.
Example: what is the first event mentioned?, Context: The Russian Revolution is the series of revolutions in Russia in 1917, which destroyed the Tsarist autocracy and led to the creation of the Soviet Union. Following the abdication of Nicholas II of Russia, the Russian Provisional Government was established. In October 1917, a red faction revolution occurred in which the Red Guard, armed groups of workers and deserting soldiers directed by the Bolshevik Party, seized control of Saint Petersburg (then known as Petrograd) and began an immediate armed takeover of cities and villages throughout the former Russian Empire.
Example solution: Russian Revolution
Example explanation: This is a good example, and the Russian Revolution is the first event mentioned.

Problem: How do the trials occur?, Context: In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.
Solution: Following IND approval, three phases of progressively larger human clinical trials may be conducted