Problem: Given the question: Information:  - Not to be confused with Wharton 's duct ( submandibular duct ) Warthin 's tumor or Warthin tumour , also known as papillary cystadenoma lymphomatosum , monomorphic adenoma or adenolymphoma , is a benign cystic tumor of the salivary glands containing abundant lymphocytes and germinal centers ( lymph node - like stroma ) . It is named for pathologist Aldred Scott Warthin , who described two cases in 1929 .  - Cystadenoma (or "cystoma") is a type of cystic adenoma.  - An adenoma (from Greek , "adeno-", "gland" + -, "-oma", "tumor") (plural adenomas or adenomata ) is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or both. Adenomas can grow from many glandular organs, including the adrenal glands, pituitary gland, thyroid, prostate, and others. Some adenomas grow from epithelial tissue in nonglandular areas but express glandular tissue structure (as can happen in familial polyposis coli). Although adenomas are benign, over time they may transform to become malignant, at which point they are called adenocarcinomas. Most adenomas do not transform. But even while benign, they have the potential to cause serious health complications by compressing other structures (mass effect) and by producing large amounts of hormones in an unregulated, non-feedback-dependent manner (causing paraneoplastic syndromes). Some adenomas are too small to be seen macroscopically but can still cause clinical symptoms.    Given the information, choose the subject and object entities that have the relation of 'instance of'.
++++++++++++++++++++++++++++++++
The answer is:
warthin's tumor , benign tumor


Problem: Given the question: Information:  - Berengaria of León (1204  12 April 1237) was the third wife but only empress consort of John of Brienne, Latin Emperor of Constantinople.  - Jerusalem , is a city located on a plateau in the Judaean Mountains between the Mediterranean and the Dead Sea. One of the oldest cities in the world, Jerusalem was named as ""Urusalima"" on ancient Mesopotamian cuneiform tablets, probably meaning "City of Shalem" after a Canaanite deity, during the early Canaanite period (approximately 2400 BCE). During the Israelite period, significant construction activity in Jerusalem began in the 9th century BCE (Iron Age II), and in the 8th century the city developed into the religious and administrative center of the Kingdom of Judah. It is considered a holy city in the three major Abrahamic religions of Judaism, Christianity and Islam.  - The King of Jerusalem was the supreme ruler of the Kingdom of Jerusalem, the Crusader state founded by Christian princes in 1099 when the First Crusade took the city.  - Constantinople  was the capital city of the Roman/Byzantine Empire (3301204 and 12611453), and also of the brief Latin (12041261), and the later Ottoman (14531923) empires. It was reinaugurated in 324 AD from ancient Byzantium as the new capital of the Roman Empire by Emperor Constantine the Great, after whom it was named, and dedicated on 11 May 330 AD.  - John of Brienne (1170  27 March 1237), also known as John I, was King of Jerusalem from 1210 to 1225 and Latin Emperor of Constantinople from 1229 to 1237. He was the youngest son of Erard II of Brienne, a wealthy nobleman in Champagne. John, originally destined for an ecclesiastical career, became a knight and owned small estates in Champagne around 1200. After the death of his brother, Walter III, he ruled the County of Brienne on behalf of his minor nephew Walter IV (who lived in southern Italy).  - Alphonso of Brienne or Alphonse I de Brienne , called Alphonse d'Acre ( c. 1228 -- August 25 , 1270 ) was the son of John of Brienne and Berengaria of León , born in Acre . He was the Grand Butler of France in 1258 . By his marriage ( bef . 1250 ) to Marie , Countess of Eu he became Count of Eu . He was also Grand Chamberlain of France , and died in Tunis on the Seventh Crusade . He had at least two children by Marie : John I of Brienne , Count of Eu Blanche ( d. bef . 1338 ) , Abbess of Maubuisson Alphonso 's possible children : Isabella Margaret Guy    Given the information, choose the subject and object entities that have the relation of 'date of birth'.
++++++++++++++++++++++++++++++++
The answer is:
alphonso of brienne , 1225