Information:  - Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).  - Cycloguanil is a dihydrofolate reductase inhibitor , and is a metabolite of the antimalarial drug proguanil ; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil . However , more recent work has indicated that , while proguanil is synergistic with the drug atovaquone ( as in the combination Malarone ) , cycloguanil is in fact antagonistic to the effects of atovaquone , suggesting that , unlike cycloguanil , proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition . Although cycloguanil is not currently in general use as an antimalarial , the continuing development of resistance to current antimalarial drugs has led to renewed interest in studying the use of cycloguanil in combination with other drugs .  - Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the "DHFR" gene. It is found in the q11q22 region of chromosome 5. Bacterial species possess distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar.  - A dihydrofolate reductase inhibitor (DHFR inhibitor) is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate.  - Atovaquone (alternative spelling: atavaquone) is a chemical compound that belongs to the class of naphthoquinones. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. It is manufactured in the US in the liquid form, or oral suspension, under the brand name Mepron.    Given the information, choose the subject and object entities that have the relation of 'instance of'.
Ans: cycloguanil , chemical compound

Information:  - Gondia district, also known as Gondiya district, is an administrative district in the state of Maharashtra in India. The district headquarters are located at Gondia (Gondiya). The district occupies an area of 5,431 km² and has a population of 1,200,707 of which 11.95% were urban (as of 2001). The district is part of Nagpur Division.  - Area is the quantity that expresses the extent of a two-dimensional figure or shape, or planar lamina, in the plane. Surface area is its analog on the two-dimensional surface of a three-dimensional object. Area can be understood as the amount of material with a given thickness that would be necessary to fashion a model of the shape, or the amount of paint necessary to cover the surface with a single coat. It is the two-dimensional analog of the length of a curve (a one-dimensional concept) or the volume of a solid (a three-dimensional concept).  - Mahurkuda Village in Arjuni Morgaontahsil in Gondia district is 7 km from Arjuni . It well known for its literacy , a village with population of 3000 plus and literacy more than 70 % .  - Gondia also spelt as Gondiya is a major city in the state of Maharashtra in Central India, and is the administrative headquarters of the Gondia District. Gondia is also known as Rice City due to the abundance of rice mills in the area. It is famous for birsi Airport .Gondia is very close to the state of Madhya Pradesh, Chhattishgarh, and is considered the gateway to Maharashtra from Central and Eastern India.There are large number of rice mills and some small scale tobacco industries.  - India, officially the Republic of India ("Bhrat Gaarjya"), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country (with over 1.2 billion people), and the most populous democracy in the world. It is bounded by the Indian Ocean on the south, the Arabian Sea on the southwest, and the Bay of Bengal on the southeast. It shares land borders with Pakistan to the west; China, Nepal, and Bhutan to the northeast; and Myanmar (Burma) and Bangladesh to the east. In the Indian Ocean, India is in the vicinity of Sri Lanka and the Maldives. India's Andaman and Nicobar Islands share a maritime border with Thailand and Indonesia. Its capital is New Delhi; other metropolises include Mumbai, Kolkata, Chennai, Bangalore, Hyderabad and Ahmedabad.  - A population is the number of all the organisms of the same group or species, which live in a particular geographical area, and have the capability of interbreeding.  - Nagpur Division is one of six administrative divisions of Maharashtra State in India. Nagpur is the easternmost division in the state, with an administrative headquarters in the city of Nagpur. it covers 19,821 sq mi [51,336 km].Amravati and Nagpur divisions make up the region of Vidarbha.  History. Nagpur Division was created in 1861, when the Central Provinces administrative division of British India was created by merging the Nagpur Province and the Saugor and Nerbudda Territories. Before 1861, Nagpur Division had been part of Nagpur Province, which had been created after the Nagpur kingdom was annexed by the British in 1853 by means of the Doctrine of lapse. The British Nagpur Division included the current districts as well as Balaghat District, currently part of Madhya Pradesh.  - Maharashtra (Marathi:  pronunciation: , abbr. MH) is a state in the western region of India and is India's third-largest state by area and is also the world's second-most populous sub-national entity. It has over 112 million inhabitants and its capital, Mumbai, has a population of approximately 18 million. Nagpur is Maharashtra's second capital as well as its winter capital. Maharashtra's business opportunities along with its potential to offer a higher standard of living attract migrants from all over India.    Given the information, choose the subject and object entities that have the relation of 'located in the administrative territorial entity'.
Ans: mahurkuda , maharashtra