Information:  - Metabolic wastes or excretes are substances left over from metabolic processes (such as cellular respiration), which cannot be used by the organism (they are surplus or toxic), and must therefore be excreted. This includes nitrogen compounds, water, CO, phosphates, sulfates, etc. Animals treat these compounds as excretes. Plants have chemical "machinery" which transforms some of them (primarily the nitrogen compounds) into useful substances, and it has been shown by Brian J. Ford that abscissa leaves also carry wastes away from the parent plant. In this way, Ford argues that the shed leaf acts as an "excretory" (an organ carrying away excretory products).  - Surgery (from the "cheirourgik" (composed of , "hand", and , "work"), via , meaning "hand work") is an ancient medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance or to repair unwanted ruptured areas (for example, a perforated ear drum).  - Blood transfusion is generally the process of receiving blood or blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern medical practice commonly uses only components of the blood, such as red blood cells, white blood cells, plasma, clotting factors, and platelets.  - Apheresis ( ("aphairesis", "a taking away")) is a medical technology in which the blood of a person is passed through an apparatus that separates out one particular constituent and returns the remainder to the circulation. It is thus an extracorporeal therapy.  - Transfusion medicine (or "transfusiology") is the branch of medicine that is concerned with transfusion of blood and blood components. It encompasses issues of blood donation, immunohematology and other laboratory testing, transfusion practices, therapeutic apheresis, stem cell collections, cellular therapy, and coagulation. Laboratory management and understanding of state and federal regulations related to blood products are also a large part of the field.  - Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.  - Platelets, also called thrombocytes (thromb- + -cyte, "blood clot cell"), are a component of blood whose function (along with the coagulation factors) is to stop bleeding by clumping and clotting blood vessel injuries. Platelets have no cell nucleus: they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow, and then enter the circulation. These unactivated platelets are biconvex discoid (lens-shaped) structures, 23 µm in greatest diameter. Platelets are found only in mammals, whereas in other animals (e.g. birds, amphibians) thrombocytes circulate as intact mononuclear cells.  - The liver is a vital organ of vertebrates and some other animals. In the human, it is located in the upper right quadrant of the abdomen, below the diaphragm. The liver has a wide range of functions, including detoxification of various metabolites, protein synthesis, and the production of biochemicals necessary for digestion.  - In transfusion medicine , transfusion associated circulatory overload ( TACO ) is a transfusion reaction ( an adverse effect of blood transfusion ) that occurs due to a rapid transfusion of a large volume of blood .  - White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system.  - In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery.  - Medicine (British English ; American English ) is the science and practice of the diagnosis, treatment, and prevention of disease. The word "medicine" is derived from Latin "medicus", meaning "a physician". Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.  - Red blood cells (RBCs), also called erythrocytes, are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O) to the body tissuesvia blood flow through the circulatory system. RBCs take up oxygen in the lungs, or gills of fish, and release it into tissues while squeezing through the body's capillaries.  - Oxygen is a chemical element with symbol O and atomic number 8. It is a member of the chalcogen group on the periodic table and is a highly reactive nonmetal and oxidizing agent that readily forms oxides with most elements as well as other compounds. By mass, oxygen is the third-most abundant element in the universe, after hydrogen and helium. At standard temperature and pressure, two atoms of the element bind to form dioxygen, a colorless and odorless diatomic gas with the formula . This is an important part of the atmosphere and diatomic oxygen gas constitutes 20.8% of the Earth's atmosphere. Additionally, as oxides the element makes up almost half of the Earth's crust.  - A blood product is any component of the blood which is collected from a donor for use in a blood transfusion. Whole blood is uncommonly used in transfusion medicine; most blood products consist of specific processed components such as red blood cells, blood plasma, or platelets.  - Body fluid, bodily fluids or biofluids are liquids originating from inside the bodies of living people. They include fluids that are excreted or secreted from the body, and body water that normally is not.  - A nutrient is a component in foods that an organism uses to survive and grow. Macronutrients provide the bulk energy an organism's metabolic system needs to function while micronutrients provide the necessary cofactors for metabolism to be carried out. Both types of nutrients can be acquired from the environment. Micronutrients are used to build and repair tissues and to regulate body processes while macronutrients are converted to, and used for, energy. Methods of nutrient intake are different for plants and animals. Plants take in nutrients directly from the soil through their roots and from the atmosphere through their leaves. Animals and protists have specialized digestive systems that work to break down macronutrients for energy and utilize micronutrients for both metabolism and anabolism (constructive synthesis) in the body.    After reading the paragraphs above, we are interested in knowing the entity with which 'transfusion associated circulatory overload' exhibits the relationship of 'instance of'. Find the answer from the choices below.  Choices: - blood cell  - blood vessel  - body fluid  - bone  - branch  - cell  - chemical  - chemical element  - component  - dioxygen  - disease  - drum  - energy  - environment  - field  - fluid  - formula  - function  - health  - human  - humans  - injury  - intervention  - leaf  - medicine  - member  - nucleus  - number  - nutrient  - organ  - organism  - person  - practice  - process  - product  - production  - protein  - range  - release  - research  - science  - soil  - standard  - state  - surgery  - system  - technology  - temperature  - word  - work
A:
disease