Given the task definition and input, reply with output. In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).

Context: Testosterone is the primary male sex hormone and an anabolic steroid. In men, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. In addition, testosterone is essential for health and well-being, and for the prevention of osteoporosis. Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss., South Asia or Southern Asia is a term used to represent the southern region of the Asian continent, which comprises the sub-Himalayan SAARC countries and, for some authorities, adjoining countries to the west and east. Topographically, it is dominated by the Indian Plate, which rises above sea level as Nepal and northern parts of India situated south of the Himalayas and the Hindu Kush. South Asia is bounded on the south by the Indian Ocean and on land (clockwise, from west) by West Asia, Central Asia, East Asia, and Southeast Asia., Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyze, chemical reactions. The molecules at the beginning of the process upon which enzymes may act are called substrates and the enzyme converts these into different molecules, called products. Almost all metabolic processes in the cell need enzymes in order to occur at rates fast enough to sustain life. The set of enzymes made in a cell determines which metabolic pathways occur in that cell. The study of enzymes is called "enzymology"., Asia-Pacific or Asia Pacific (abbreviated as APAC, Asia-Pac, AsPac, APJ, JAPA or JAPAC) is the part of the world in or near the Western Pacific Ocean. The region varies in size depending on which context, but it typically includes much of East Asia, South Asia, Southeast Asia, and Oceania., Dihydrotestosterone (DHT), or 5-dihydrotestosterone (5-DHT), also known as 5-androstan-17-ol-3-one, is an endogenous androgen sex steroid and hormone. The enzyme 5-reductase catalyzes the formation of DHT from testosterone in certain tissues including the prostate gland, seminal vesicles, epididymides, skin, hair follicles, liver, and brain. This enzyme mediates reduction of the C4-5 double bond of testosterone. Relative to testosterone, DHT is considerably more potent as an agonist of the androgen receptor (AR)., Southeast Asia or Southeastern Asia is a subregion of Asia, consisting of the countries that are geographically south of China, east of India, west of New Guinea and north of Australia. The region lies near the intersection of geological plates, with heavy seismic and volcanic activity. Southeast Asia consists of two geographic regions:, Asia is Earth's largest and most populous continent, located primarily in the eastern and northern hemispheres and sharing the continental landmass of Eurasia with the continent of Europe. Asia covers an area of , about 30% of Earth's total land area and 8.7% of the Earth's total surface area. The continent, which has long been home to the majority of the human population, was the site of many of the first civilizations. Asia is notable for not only its overall large size and population, but also dense and large settlements as well as vast barely populated regions within the continent of 4.4 billion people., East Asia is the eastern subregion of the Asian continent, which can be defined in either geographical or ethno-cultural terms. Geographically and geopolitically, it includes China, Hong Kong, and Macao; Mongolia and Taiwan; North and South Korea; and Japan; it covers about , or about 28% of the Asian continent, about twice the area of Europe., A steroid is an organic compound with four rings arranged in a specific configuration. Examples include the dietary lipid cholesterol, the sex hormones estradiol and testosterone and the anti-inflammatory drug dexamethasone. Steroids have two principal biological functions: certain steroids (such as cholesterol) are important components of cell membranes which alter membrane fluidity, and many steroids are signaling molecules which activate steroid hormone receptors., An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist., Mesterolone is an orally applicable androgen and dihydrotestosterone ( DHT ) derivative . It is sold under the brand name Proviron ( as Provironum in Asia - Pacific region ) , by Bayer Schering Pharma ( earlier by Schering ) . In the late 70s and early 80s , it was used with some success in controlled studies of men suffering from various forms of depression . Mesterolone is a relatively weak androgen and rarely used for replacement therapies ., 5-reductases, also known as 3-oxo-5-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism. There are three isoenzymes of 5-reductase, which vary in different tissues with age., The Pacific Ocean is the largest of the Earth's oceanic divisions. It extends from the Arctic Ocean in the north to the Southern Ocean (or, depending on definition, to Antarctica) in the south and is bounded by Asia and Australia in the west and the Americas in the east., The liver is a vital organ of vertebrates and some other animals. In the human, it is located in the upper right quadrant of the abdomen, below the diaphragm. The liver has a wide range of functions, including detoxification of various metabolites, protein synthesis, and the production of biochemicals necessary for digestion., Skin is the soft outer covering of vertebrates. Other animal coverings, such as the arthropod exoskeleton have different developmental origin, structure and chemical composition. The adjective cutaneous means "of the skin" (from Latin "cutis", skin). In mammals, the skin is an organ of the integumentary system made up of multiple layers of ectodermal tissue, and guards the underlying muscles, bones, ligaments and internal organs. Skin of a different nature exists in amphibians, reptiles, and birds. All mammals have some hair on their skin, even marine mammals like whales, dolphins, and porpoises which appear to be hairless.
The skin interfaces with the environment and is the first line of defense from external factors. For example, the skin plays a key role in protecting the body against pathogens and excessive water loss. Its other functions are insulation, temperature regulation, sensation, and the production of vitamin D folates. Severely damaged skin may heal by forming scar tissue. This is sometimes discoloured and depigmented. The thickness of skin also varies from location to location on an organism. In humans for example, the skin located under the eyes and around the eyelids is the thinnest skin in the body at 0.5 mm thick, and is one of the first areas to show signs of aging such as "crows feet" and wrinkles. The skin on the palms and the soles of the feet is 4 mm thick and the back is 14 mm thick and is the thickest skin in the body. The speed and quality of wound healing in skin is promoted by the reception of estrogen., Androgen (from Greek "andro" meaning male human being), also called androgenic hormone or testoid, is any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes the activity of the primary male sex organs and development of male secondary sex characteristics. Androgens were first discovered in 1936. Androgens increase in both boys and girls during puberty. Androgens are also the original anabolic steroids and the precursor of all estrogens. The primary and most well-known androgen is testosterone. Dihydrotestosterone (DHT) and androstenedione are less known generally, but are of equal importance in male development. DHT in the embryo life causes differentiation of penis, scrotum and prostate. Later in life DHT contributes to balding, prostate growth and sebaceous gland activity. Although androgens are described as male sex hormones, both males and females have them to varying degrees, as is also true of estrogens. They are one of three types of sex hormones, the others being estrogens like estradiol and progestogens like progesterone., Oceania (or ), also known as Oceanica, is a region centred on the islands of the tropical Pacific Ocean. Opinions of what constitutes Oceania range from its three subregions of Melanesia, Micronesia, and Polynesia to, more broadly, the entire insular region between Southeast Asia and the Americas, including Australasia and the Malay Archipelago., The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. The brain is located in the head, usually close to the sensory organs for senses such as vision. The brain is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 1533 billion neurons, each connected by synapses to several thousand other neurons. These neurons communicate with one another by means of long protoplasmic fibers called axons, which carry trains of signal pulses called action potentials to distant parts of the brain or body targeting specific recipient cells., The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor., A double bond in chemistry is a chemical bond between two chemical elements involving four bonding electrons instead of the usual two. The most common double bond, that is between two carbon atoms, can be found in alkenes. Many types of double bonds exist between two different elements. For example, in a carbonyl group with a carbon atom and an oxygen atom. Other common double bonds are found in azo compounds (N=N), imines (C=N) and sulfoxides (S=O). In skeletal formula the double bond is drawn as two parallel lines (=) between the two connected atoms; typographically, the equals sign is used for this. Double bonds were first introduced in chemical notation by prominent Russian chemist Alexander Butlerov., A hair follicle is a mammalian skin organ that produces hair. Hair production occurs in phases, including growth (anagen), cessation (catagen), and rest (telogen) phases. Stem cells are responsible for hair production. The shape of the hair follicle has an effect on the hair shape and texture of the individual's hair., Subject: mesterolone, Relation: has_part, Options: (A) 0 (B) a (C) alexander (D) antarctica (E) arctic ocean (F) asia (G) brain (H) c (I) carbon (J) cell (K) chemistry (L) earth (M) eurasia (N) europe (O) formation (P) group (Q) human (R) key (S) lead (T) liver (U) malay archipelago (V) member (W) metabolism (X) micronesia (Y) o (Z) oceania ([) one (\) organ (]) organism (^) outer (_) pacific ocean (`) polynesia (a) s (b) set (c) south korea (d) speed (e) stem (f) temperature (g) the americas
carbon