In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).

[Q]: Context: Germany, officially the Federal Republic of Germany, is a federal parliamentary republic in central-western Europe. It includes 16 constituent states, covers an area of , and has a largely temperate seasonal climate. With about 82 million inhabitants, Germany is the most populous member state of the European Union. After the United States, it is the second most popular immigration destination in the world. Germany's capital and largest metropolis is Berlin. Other major cities include Hamburg, Munich, Cologne, Frankfurt, Stuttgart and Düsseldorf., Beijing (formerly romanised as Peking) is the capital of the People's Republic of China and the world's third most populous city proper. It is also one of the world's most populous capital cities. The city, located in northern China, is governed as a direct-controlled municipality under the national government with 16 urban, suburban, and rural districts. Beijing Municipality is surrounded by Hebei Province with the exception of neighbouring Tianjin Municipality to the southeast; together the three divisions form the Jingjinji metropolitan region and the national capital region of China., Asia is Earth's largest and most populous continent, located primarily in the eastern and northern hemispheres and sharing the continental landmass of Eurasia with the continent of Europe. Asia covers an area of , about 30% of Earth's total land area and 8.7% of the Earth's total surface area. The continent, which has long been home to the majority of the human population, was the site of many of the first civilizations. Asia is notable for not only its overall large size and population, but also dense and large settlements as well as vast barely populated regions within the continent of 4.4 billion people., Ukraine (tr. ) is a sovereign state in Eastern Europe, bordered by Russia to the east and northeast, Belarus to the northwest, Poland and Slovakia to the west, Hungary, Romania, and Moldova to the southwest, and the Black Sea and Sea of Azov to the south and southeast, respectively. Ukraine is currently in territorial dispute with Russia over the Crimean Peninsula which Russia annexed in 2014 but which Ukraine and most of the international community recognise as Ukrainian. Including Crimea, Ukraine has an area of , making it the largest country entirely within Europe and the 46th largest country in the world. It has a population of about 44.5 million, making it the 32nd most populous country in the world., Indonesia (or ; Indonesian: ), officially the Republic of Indonesia, is a unitary sovereign state and transcontinental country located mainly in Southeast Asia with some territories in Oceania. Situated between the Indian and Pacific oceans, it is the world's largest island country, with more than seventeen thousand islands. At , Indonesia is the world's 14th-largest country in terms of land area and world's 7th-largest country in terms of combined sea and land area. It has an estimated population of over 260 million people and is the world's fourth most populous country, the most populous Austronesian nation, as well as the most populous Muslim-majority country. The world's most populous island of Java contains more than half of the country's population., Hamburg (local pronunciation ; Low German/Low Saxon: "Hamborg" ), officially "Freie und Hansestadt Hamburg" (Free and Hanseatic City of Hamburg), is the second largest city in Germany and the eighth largest city in the European Union. It is the second smallest German state by area. Its population is over 1.7 million people, and the wider Hamburg Metropolitan Region covers more than 5.1 million inhabitants. The city is situated on the river Elbe., Easter, also called Pascha "(Greek/Latin)" or Resurrection Sunday, is a festival and holiday celebrating the resurrection of Jesus from the dead, described in the New Testament as having occurred on the third day of his burial after his crucifixion by Romans at Calvary 30 AD. It is the culmination of the Passion of Jesus, preceded by Lent (or Great Lent), a forty-day period of fasting, prayer, and penance., The Atlantic Ocean is the second largest of the world's oceans with a total area of about . It covers approximately 20 percent of the Earth's surface and about 29 percent of its water surface area. It separates the "Old World" from the "New World"., The Rhine (, , ) is a European river that begins in the Swiss canton of Graubünden in the southeastern Swiss Alps, forms part of the 
Swiss-Austrian, Swiss-Liechtenstein, Swiss-German and then the Franco-German border, then flows through the Rhineland and eventually empties into the North Sea in the Netherlands. 
The largest city on the river Rhine is Cologne, Germany, with a population of more than 1,050,000 people. It is the second-longest river in Central and Western Europe (after the Danube), at about , with an average discharge of about ., Korea is a historical state in East Asia, since 1945 divided into two distinct sovereign states: North Korea (officially the "Democratic People's Republic of Korea") and South Korea (officially the "Republic of Korea"). Located on the Korean Peninsula, Korea is bordered by China to the northwest and Russia to the northeast. It is separated from Japan to the east by the Korea Strait and the East Sea., A country is a region that is identified as a distinct national entity in political geography. A country may be an independent sovereign state or one that is occupied by another state, as a non-sovereign or formerly sovereign political division, or a geographic region associated with sets of previously independent or differently associated people with distinct political characteristics. Regardless of the physical geography, in the modern internationally accepted legal definition as defined by the League of Nations in 1937 and reaffirmed by the United Nations in 1945, a resident of a country is subject to the independent exercise of legal jurisdiction., Moscow (or ) is the capital and most populous city of Russia, with 12.2 million residents within the city limits and 16.8 million within the urban area. Moscow has the status of a Russian federal city., Novosibirsk is the third-most populous city in Russia after Moscow and St. Petersburg. It is the most populous city in Asian Russia, with a population of 1,473,754 as of the 2010 Census. It is the administrative center of Novosibirsk Oblast as well as of the Siberian Federal District. The city is located in the southwestern part of Siberia on the banks of the Ob River adjacent to the Ob River Valley, near the large water reservoir formed by the dam of the Novosibirsk Hydro Power Plant, and occupies an area of ., Poland, officially the Republic of Poland, is a country in Central Europe, situated between the Baltic Sea in the north and two mountain ranges (the Sudetes and Carpathian Mountains) in the south. Bordered by Germany to the west; the Czech Republic and Slovakia to the south; Ukraine and Belarus to the east; and the Baltic Sea, Kaliningrad Oblast (a Russian exclave) and Lithuania to the north. The total area of Poland is , making it the 69th largest country in the world and the 9th largest in Europe. With a population of over 38.5 million people, Poland is the 34th most populous country in the world, the 8th most populous country in Europe and the sixth most populous member of the European Union. Poland is a unitary state divided into 16 administrative subdivisions, and its capital and largest city is Warsaw. Other metropolises include Kraków, Wrocaw, Pozna, Gdask and Szczecin., Berlin is the capital and the largest city of Germany as well as one of its constituent 16 states. With a population of approximately 3.5 million people, Berlin is the second most populous city proper and the seventh most populous urban area in the European Union. Located in northeastern Germany on the banks of rivers Spree and Havel, it is the centre of the Berlin-Brandenburg Metropolitan Region, which has about 6 million residents from more than 180 nations. Due to its location in the European Plain, Berlin is influenced by a temperate seasonal climate. Around one-third of the city's area is composed of forests, parks, gardens, rivers and lakes., Australia, officially the Commonwealth of Australia, is a country comprising the mainland of the Australian continent, the island of Tasmania and numerous smaller islands. It is the world's sixth-largest country by total area. The neighbouring countries are Papua New Guinea, Indonesia and East Timor to the north; the Solomon Islands and Vanuatu to the north-east; and New Zealand to the south-east. Australia's capital is Canberra, and its largest urban area is Sydney., Toulouse is the capital city of the southwestern French department of Haute-Garonne, as well as of the Occitanie region. The city lies on the banks of the River Garonne, from the Mediterranean Sea, from the Atlantic Ocean, and from Paris. It is the fourth-largest city in France with 466,297 inhabitants in January 2014. 
The Toulouse Metro area is, with 1 312 304 inhabitants as of 2014, France's 4th metropolitan area after Paris, Lyon and Marseille and ahead of Lille and Bordeaux., China, officially the People's Republic of China (PRC), is a unitary sovereign state in East Asia. With a population of over 1.381 billion, it is the world's most populous country. The state is governed by the Communist Party of China, and its capital is Beijing. It exercises jurisdiction over 22 provinces, five autonomous regions, four direct-controlled municipalities (Beijing, Tianjin, Shanghai, and Chongqing), and two mostly self-governing special administrative regions (Hong Kong and Macau), and claims sovereignty over Taiwan. The country's major urban areas include Shanghai, Guangzhou, Beijing, Chongqing, Shenzhen, Tianjin and Hong Kong. China is a great power and a major regional power within Asia, and has been characterized as a potential superpower., Russia (from the  Rus'), also officially known as the Russian Federation, is a country in Eurasia. At , Russia is the largest country in the world by surface area, covering more than one-eighth of the Earth's inhabited land area, and the ninth most populous, with over 140 million people at the end of March 2016. The European western part of the country is much more populated and urbanised than the eastern, about 77% of the population live in European Russia. Russia's capital Moscow is one of the largest cities in the world, other major urban centers include Saint Petersburg, Novosibirsk, Yekaterinburg, Nizhny Novgorod and Samara., Nice (; Niçard , classical norm, or "", nonstandard,  ) is the fifth most populous city in France and the capital of the Alpes-Maritimes "département". The urban area of Nice extends beyond the administrative city limits, with a population of about 1 million on an area of . Located in the French Riviera, on the south east coast of France on the Mediterranean Sea, at the foot of the Alps, Nice is the second-largest French city on the Mediterranean coast and the second-largest city in the Provence-Alpes-Côte d'Azur region after Marseille. Nice is about 13 kilometres (8 miles) from the principality of Monaco, and its airport is a gateway to the principality as well., Nizhny Novgorod, colloquially shortened to Nizhny, is a city in the administrative center of Nizhny Novgorod Oblast and Volga Federal District in Russia. From 1932 to 1990, it was known as Gorky, after the writer Maxim Gorky, who was born there. The city is an important economic, transportation, scientific, educational and cultural center in Russia and the vast Volga-Vyatka economic region, and is the main center of river tourism in Russia. In the historical part of the city there are a large number of universities, theaters, museums and churches. Nizhny Novgorod is located about 400 km east of Moscow, where the Oka empties into the Volga. Population: , French Guiana (pronounced or ), officially called Guiana, is an overseas department and region of France, located on the north Atlantic coast of South America in the Guyanas. It borders Brazil to the east and south, and Suriname to the west. Its area has a very low population density of only 3 inhabitants per km, with half of its 244,118 inhabitants in 2013 living in the metropolitan area of Cayenne, its capital. By land area, it is the second largest region of France and the largest outermost region within the European Union., Hungary is a unitary parliamentary republic in Central Europe. It covers an area of , situated in the Carpathian Basin and bordered by Slovakia to the north, Romania to the east, Serbia to the south, Croatia to the southwest, Slovenia to the west, Austria to the northwest, and Ukraine to the northeast. With about 10 million inhabitants, Hungary is a medium-sized member state of the European Union. The official language is Hungarian, which is the most widely spoken Uralic language in the world. Hungary's capital and largest metropolis is Budapest, a significant economic hub, classified as an Alpha- global city. Major urban areas include Debrecen, Szeged, Miskolc, Pécs and Gyr., Slovakia, officially the Slovak Republic, is a landlocked country in Central Europe. It is bordered by the Czech Republic and Austria to the west, Poland to the north, Ukraine to the east and Hungary to the south. Slovakia's territory spans about and is mostly mountainous. The population is over 5 million and comprises mostly ethnic Slovaks. The capital and largest city is Bratislava. The official language is Slovak, a member of the Slavic language family., Tasmania (abbreviated as Tas and known colloquially as "Tassie") is an island state of the Commonwealth of Australia. It is located to the south of the Australian mainland, separated by Bass Strait. The state encompasses the main island of Tasmania, the 26th-largest island in the world, and the surrounding 334 islands. The state has a population of around 518,500, just over forty percent of which resides in the Greater Hobart precinct, which forms the metropolitan area of the state capital and largest city, Hobart., Shanghai (": Zånhae" ), often abbreviated as Hu or Shen, is one of the four direct-controlled municipalities of the People's Republic of China. It is the most populous city proper in the world, with a population of more than 24 million . It is a global financial centre and transport hub, with the world's busiest container port. Located in the Yangtze River Delta in East China, Shanghai sits on the south edge of the mouth of the Yangtze in the middle portion of the Chinese coast. The municipality borders the provinces of Jiangsu and Zhejiang to the north, south and west, and is bounded to the east by the East China Sea., Düsseldorf (Low Franconian, Ripuarian: "Düsseldörp" ) is the capital city of the German state of North Rhine-Westphalia and the seventh most populous city in Germany. Düsseldorf is an international business and financial centre, renowned for its fashion and trade fairs. The city is headquarters to one Fortune Global 500 and two DAX companies. Messe Düsseldorf organises nearly one fifth of premier trade shows., Munich (also in British English ) is the capital and largest city of the German state of Bavaria, on the banks of River Isar north of the Bavarian Alps. Munich is the third largest city in Germany, after Berlin and Hamburg, and the 12th biggest city of the European Union, with a population of above 1.5 million. The Munich Metropolitan Region is home to 5.8 million people., Stuttgart ( Swabian: "Schduagert"), often nicknamed the ""Schwabenmetropole"" in reference to its location in the center of Swabia and the local dialect spoken by some natives, is the capital and largest city of the German state of Baden-Württemberg. It is located on the Neckar river in a fertile valley locally known as the "Stuttgarter Kessel" an hour from the Swabian Jura and the Black Forest. Stuttgart's name comes from the Old High German word ""Stuogarten"," or "stud farm"  a reference to the city's founding in 950 AD as a stud farm. Stuttgarts urban area has a population of 623,738, and a further making it the sixth largest city in Germany, 2.7 million people live in the citys administrative region, and another 5.3 million people in its metropolitan area, making it the fourth largest metropolitan area in Germany., Russia is not proportionately populated between the smaller western portion (almost 25%) of the country that is considered part of Europe, and the larger eastern portion (more than 75%) that is part of Asia. European Russia contains about 77% of the country's population (110,000,000 people out of about 144,000,000) in an area comprising almost 4 million km (1.54 million mi); an average of 27.5 persons per km (70 per mi). This territory makes up 38% of Europe. Its eastern border is defined by the Ural Mountains and in the south, it is defined by the border with Kazakhstan. This area includes Moscow and Saint Petersburg, the two largest cities in Russia., The euro (sign: €; code: EUR) is the official currency of the eurozone, which consists of 19 of the member states of the European Union: Austria, Belgium, Cyprus, Estonia, Finland, France, Germany, Greece, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Portugal, Slovakia, Slovenia, and Spain. The currency is also officially used by the institutions of the European Union and four other European countries, as well as unilaterally by two others, and is consequently used daily by some 337 million Europeans . Outside of Europe, a number of overseas territories of EU members also use the euro as their currency., Saint Petersburg is Russia's second-largest city after Moscow, with five million inhabitants in 2012, and an important Russian port on the Baltic Sea. It is politically incorporated as a federal subject (a federal city). Situated on the Neva River, at the head of the Gulf of Finland on the Baltic Sea, it was founded by Tsar Peter the Great on May . In 1914, the name was changed from Saint Petersburg to Petrograd, in 1924 to Leningrad, and in 1991 back to Saint Petersburg. Between 17131728 and 17321918, Saint Petersburg was the imperial capital of Russia. In 1918, the central government bodies moved to Moscow., Frankfurt am Main is a metropolis and the largest city in the German state of Hesse and the fifth-largest city in Germany, with a 2015 population of 731,095 within its administrative boundaries, and 2.3 million in its urban area. The city is at the centre of the larger Frankfurt Rhine-Main Metropolitan Region, which has a population of 5.8 million and is Germany's second-largest metropolitan region after Rhine-Ruhr. Since the enlargement of the European Union in 2013, the geographic centre of the EU is about to the east of Frankfurt's CBD, the Bankenviertel. Frankfurt is culturally and ethnically diverse, with around half of the population, and a majority of young people, having a migration background. A quarter of the population are foreign nationals, including many expatriates., Parallels is a privately held virtualization technology company with offices in 15 countries , including the USA , Germany , UK , France , Japan , China , Russia , Australia and Ukraine . Parallels headquarters is in Renton , Washington . The company has more than 1000 employees as of 2015 . In March 2015 , Parallels moved to two separate brands : its service provider team became Odin , while its cross-platform solutions team continues to use the name Parallels . Parallels , Inc. was an SWsoft company until January 2008 ; each company operated as a separate entity and maintained its own distinct branding . In December 2007 , Parallels parent company SWsoft announced its plans to change its name to Parallels and ship both companies ' products under the Parallels name . The merger was formalized in January 2008 . Parallels has development centers in Moscow and Novosibirsk . Parallels acquired 2X Software in February 2015 . In March 2015 Parallels rebranded their service provider business unit to Odin ., East Timor or Timor-Leste (Tetum: "Timór Lorosa'e"), officially the Democratic Republic of Timor-Leste, is a sovereign state in Maritime Southeast Asia. It comprises the eastern half of the island of Timor; the nearby islands of Atauro and Jaco; and Oecusse, an exclave on the northwestern side of the island surrounded by Indonesian West Timor. The country's size is about 15,410 km (5,400 sq mi)., France, officially the French Republic, is a country with territory in western Europe and several overseas regions and territories. The European, or metropolitan, area of France extends from the Mediterranean Sea to the English Channel and the North Sea, and from the Rhine to the Atlantic Ocean. Overseas France include French Guiana on the South American continent and several island territories in the Atlantic, Pacific and Indian oceans. France spans and had a total population of almost 67 million people as of January 2017. It is a unitary semi-presidential republic with the capital in Paris, the country's largest city and main cultural and commercial centre. Other major urban centres include Marseille, Lyon, Lille, Nice, Toulouse and Bordeaux., Tianjin, formerly romanized as Tientsin, is a metropolis in northern coastal Mainland China, administered by the People's Republic of China and one of the five national central cities of China, with a total municipal population of 15,469,500. It is governed as one of the four direct-controlled municipalities of the PRC and is thus under direct administration of the central government. Tianjin borders Hebei Province and Beijing Municipality, bounded to the east by the Bohai Gulf portion of the Yellow Sea. Part of the Bohai Economic Rim, it is the largest coastal city in northern China., Hong Kong, officially the Hong Kong Special Administrative Region of the People's Republic of China, is an autonomous territory on the Pearl River Delta of East Asia. Macau lies across the delta to the west, and the Chinese province of Guangdong borders the territory to the north. With a total land area of and a population of over 7.3 million of various nationalities, it ranks as the world's fourth most densely populated sovereign state or territory., The European Union (EU) is a political and economic union of member states that are located primarily in Europe. It has an area of , and an estimated population of over 510 million. The EU has developed an internal single market through a standardised system of laws that apply in all member states. EU policies aim to ensure the free movement of people, goods, services, and capital within the internal market, enact legislation in justice and home affairs, and maintain common policies on trade, agriculture, fisheries, and regional development. Within the Schengen Area, passport controls have been abolished. A monetary union was established in 1999 and came into full force in 2002, and is composed of 19 EU member states which use the euro currency., Romania is a sovereign state located in Southeastern Europe. It borders the Black Sea, Bulgaria, Ukraine, Hungary, Serbia, and Moldova. It has an area of and a temperate-continental climate. With 19.94 million inhabitants, the country is the seventh-most-populous member state of the European Union. The capital and largest city, Bucharest, with its 1,883,425 inhabitants is the sixth-largest city in the EU., Solomon Islands is a sovereign country consisting of six major islands and over 900 smaller islands in Oceania lying to the east of Papua New Guinea and northwest of Vanuatu and covering a land area of . The country's capital, Honiara, is located on the island of Guadalcanal. The country takes its name from the Solomon Islands archipelago, which is a collection of Melanesian islands that also includes the North Solomon Islands (part of Papua New Guinea), but excludes outlying islands, such as Rennell and Bellona, and the Santa Cruz Islands., Paris (French: ) is the capital and most populous city of France. It has an area of and a population in 2013 of 2,229,621 within its administrative limits. The city is both a commune and department, and forms the centre and headquarters of the Île-de-France, or Paris Region, which has an area of and a population in 2014 of 12,005,077, comprising 18.2 percent of the population of France., Macau (literally: "Bay Gate"), (in Portuguese, which is still widely used in the city) also spelled Macao (in English), officially the Região Administrativa Especial de Macau da República Popular da China, is an autonomous territory on the western side of the Pearl River Delta in East Asia. Macau is bordered by the city of Zhuhai in China to the North and the Pearl River Estuary to the East and South. Hong Kong lies about to its East across the Delta. With a population of 650,900 living in an area of , it is the most densely populated region in the world., Yekaterinburg, alternatively romanised as "Ekaterinburg", is the fourth-largest city in Russia and the administrative centre of Sverdlovsk Oblast, located in the middle of the Eurasian continent, on the border of Europe and Asia. At the 2010 Census, it had a population of 1,349,772., Japan ("Nippon" or "Nihon" ; formally "" or "Nihon-koku", means "State of Japan") is a sovereign island nation in Eastern Asia. Located in the Pacific Ocean, It is lying off the eastern coast of the Asia Mainland (east of China, Korea, Russia) and stretching from the Sea of Okhotsk in the north to the East China Sea and near Taiwan in the southwest. , The Communist Party of China (CPC) is the founding and ruling political party of the People's Republic of China (PRC). The CPC is the sole governing party of China, although it coexists alongside eight other legal parties that comprise the United Front; these parties, however, hold no real power or independence from the CPC. It was founded in 1921, chiefly by Chen Duxiu and Li Dazhao. The party grew quickly, and by 1949 the CPC had driven the nationalist Kuomintang (KMT) government from mainland China after the Chinese Civil War, thus leading to the establishment of the People's Republic of China. The CPC is currently the world's second largest political party with a membership of 88.76 million as of 2016 (while the Indian Bharatiya Janata Party appears to have remained the largest with a membership of 110 million as of the previous year, 2015). It also controls the world's largest armed force, the People's Liberation Army. , Subject: parallels , Relation: inception, Options: (A) 1 (B) 10 (C) 12 (D) 140 (E) 15 (F) 16 (G) 1713 (H) 19 (I) 1914 (J) 1918 (K) 1921 (L) 1924 (M) 1932 (N) 1937 (O) 1945 (P) 1991 (Q) 1999 (R) 2 (S) 20 (T) 2002 (U) 2010 (V) 2012 (W) 2013 (X) 2014 (Y) 2015 (Z) 229 ([) 24 (\) 25 (]) 260 (^) 29 (_) 30 (`) 312 (a) 400 (b) 5 (c) 500 (d) 650 (e) 7 (f) 8 (g) 900 (h) 950
[A]: 1999


[Q]: Context: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. The disease may also affect other parts of the body. This may result in a low red blood cell count, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often, symptoms come on gradually over weeks to months.
While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves the body's immune system attacking the joints. This results in inflammation and thickening of the joint capsule. It also affects the underlying bone and cartilage. The diagnosis is made mostly on the basis of a person's signs and symptoms. X-rays and laboratory testing may support a diagnosis or exclude other diseases with similar symptoms. Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others.
The goal of treatment is to reduce pain, decrease inflammation, and improve a person's overall functioning. This may be helped by balancing rest and exercise, the use of splints and braces, or the use of assistive devices. Pain medications, steroids, and NSAIDs are frequently used to help with symptoms. A group of medications called disease-modifying antirheumatic drugs (DMARDs), such as hydroxychloroquine and methotrexate, may be used to try to slow the progression of disease. Biological DMARDs may be used when disease does not respond to other treatments. However, they may have a greater rate of adverse effects. Surgery to repair, replace, or fuse joints may help in certain situations. Most alternative medicine treatments are not supported by evidence.
RA affects between 0.5 and 1% of adults in the developed world with between 5 and 50 per 100,000 people newly developing the condition each year. Onset is most frequent during middle age and women are affected 2.5 times as frequently as men. In 2013, it resulted in 38,000 deaths up from 28,000 deaths in 1990. The first recognized description of RA was made in 1800 by Dr. Augustin Jacob Landré-Beauvais (17721840) of Paris. The term "rheumatoid arthritis" is based on the Greek for watery and inflamed joints.
Signs and symptoms.
RA primarily affects joints, but it also affects other organs in more than 1525% of individuals., Fibromyalgia (FM) is a medical condition characterised by chronic widespread pain and a heightened pain response to pressure. Other symptoms include feeling tired to a degree that normal activities are affected, sleep problems, and troubles with memory. Some people also report restless legs syndrome, bowel or bladder problems, numbness and tingling, and sensitivity to noise, lights or temperature. Fibromyalgia is frequently associated with depression, anxiety, and posttraumatic stress disorder. Other types of chronic pain are also frequently present.
The cause of fibromyalgia is unknown; however, it is believed to involve a combination of genetic and environmental factors with half the risk attributed to each. The condition runs in families and many genes are believed to be involved. Environmental factors may include psychological stress, trauma, and certain infections. The pain appears to result from processes in the central nervous system and the condition is referred to as a "central sensitization syndrome". Fibromyalgia is recognized as a disorder by the US National Institutes of Health and the American College of Rheumatology. There is no specific diagnostic test. Diagnosis involves first ruling out other potential causes and verifying that a set number of symptoms are present.
The treatment of fibromyalgia can be difficult. Recommendations often include getting enough sleep, exercising regularly, and eating a healthy diet. Cognitive behavioral therapy may also be helpful. The medications duloxetine, milnacipran, or pregabalin may be used. Use of opioid pain medication is controversial with some stating their use is poorly supported by evidence and others saying that weak opioids may be reasonable if other medications are not effective. Dietary supplements also lack evidence to support their use. While fibromyalgia can last a long time, it does not result in death or tissue damage.
Fibromyalgia is estimated to affect 28% of the population. Females are affected about twice as often as males. Rates appear similar in different areas of the world and among different cultures. Fibromyalgia was first defined in 1990 with updated criteria in 2011. There is controversy about the classification, diagnosis, and treatment of fibromyalgia. While some feel the diagnosis of fibromyalgia may negatively affect a person, other research finds it to be beneficial. The term "fibromyalgia" is from New Latin, "fibro-", meaning "fibrous tissues", Greek  "myo-", "muscle", and Greek  "algos", "pain"; thus the term literally means "muscle and fibrous connective tissue pain"., A burn is a type of injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or radiation. Most burns are due to heat from hot liquids, solids, or fire. Females in many areas of the world have a higher risk related to the more frequent use of open cooking fires or unsafe cook stoves. Alcoholism and smoking are other risk factors. Burns can also occur as a result of self harm or violence between people.
Burns that affect only the superficial skin layers are known as superficial or first-degree burns. They appear red without blisters and pain typically lasts around three days. When the injury extends into some of the underlying skin layer, it is a partial-thickness or second-degree burn. Blisters are frequently present and they are often very painful. Healing can require up to eight weeks and scarring may occur. In a full-thickness or third-degree burn, the injury extends to all layers of the skin. Often there is no pain and the burn area is stiff. Healing typically does not occur on its own. A fourth-degree burn additionally involves injury to deeper tissues, such as muscle, tendons, or bone. The burn is often black and frequently leads to loss of the burned part.
Burns are generally preventable. Treatment depends on the severity of the burn. Superficial burns may be managed with little more than simple pain medication, while major burns may require prolonged treatment in specialized burn centers. Cooling with tap water may help pain and decrease damage; however, prolonged cooling may result in low body temperature. Partial-thickness burns may require cleaning with soap and water, followed by dressings. It is not clear how to manage blisters, but it is probably reasonable to leave them intact if small and drain them if large. Full-thickness burns usually require surgical treatments, such as skin grafting. Extensive burns often require large amounts of intravenous fluid, due to capillary fluid leakage and tissue swelling. The most common complications of burns involve infection. Tetanus toxoid should be given if not up to date.
In 2013, fire and heat resulted in 35 million injuries. This resulted in about 2.9 million hospitalizations and 238,000 dying. Most deaths due to burns occur in the developing world, particularly in Southeast Asia. While large burns can be fatal, treatments developed since 1960 have improved outcomes, especially in children and young adults. In the United States, approximately 96% of those admitted to a burn center survive their injuries. Burns occur at similar frequencies in men and women. The long-term outcome is related to the size of burn and the age of the person affected.
Signs and symptoms.
The characteristics of a burn depend upon its depth. Superficial burns cause pain lasting two or three days, followed by peeling of the skin over the next few days. Individuals suffering from more severe burns may indicate discomfort or complain of feeling pressure rather than pain. Full-thickness burns may be entirely insensitive to light touch or puncture. While superficial burns are typically red in color, severe burns may be pink, white or black. Burns around the mouth or singed hair inside the nose may indicate that burns to the airways have occurred, but these findings are not definitive. More worrisome signs include: shortness of breath, hoarseness, and stridor or wheezing. Itchiness is common during the healing process, occurring in up to 90% of adults and nearly all children. Numbness or tingling may persist for a prolonged period of time after an electrical injury. Burns may also produce emotional and psychological distress., Orthopedic surgery or orthopedics (alternatively spelled orthopaedic surgery and orthopaedics) is the branch of surgery concerned with conditions involving the musculoskeletal system. Orthopedic surgeons use both surgical and nonsurgical means to treat musculoskeletal trauma, spine diseases, sports injuries, degenerative diseases, infections, tumors, and congenital disorders.
Etymology.
Nicholas Andry coined the word ""orthopædics"" in French as "orthopédie", derived from the Greek words  "orthos" ("correct", "straight") and  "paidion" ("child"), when he published "Orthopedie" (translated as "Orthopædia: or the Art of Correcting and Preventing Deformities in Children") in 1741. Though as the name implies it was initially developed with attention to children, the correction of spinal and bony deformities in all stages of life eventually became the cornerstone of orthopedic practice., Septic arthritis, also known as infectious arthritis or joint infection, is the purulent invasion of a joint by an infectious agent which produces arthritis. People with artificial joints are more at risk than the general population but have slightly different symptoms, are infected with different organisms and require different treatment. Septic arthritis is considered a medical emergency. If untreated, it may destroy the joint in a period of days. The infection may also spread to other parts of the body., Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types other organs are also affected. Onset can be gradual or sudden.
There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disorder that often affects the hands and feet. Other types include gout, lupus, fibromyalgia, and septic arthritis. They are all types of rheumatic disease.
Treatment may include resting the joint and alternating between applying ice and heat. Weight loss and exercise may also be useful. Pain medications such as ibuprofen and paracetamol (acetaminophen) may be used. In some a joint replacement may be useful.
Osteoarthritis affects more than 3.8% of people while rheumatoid arthritis affects about 0.24% of people. Gout affects about 1 to 2% of the Western population at some point in their lives. In Australia about 15% of people are affected, while in the United States more than 20% of have a type of arthritis. Overall the disease becomes more common with age. Arthritis is a common reason that people miss work and can result in a decreased quality of life. The term is from Greek "arthro-" meaning joint and "-itis" meaning inflammation., A bone is a rigid organ that constitutes part of the vertebrate skeleton. Bones support and protect the various organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. Bones come in a variety of shapes and sizes and have a complex internal and external structure. They are lightweight yet strong and hard, and serve multiple functions. , Pain is a distressing feeling often caused by intense or damaging stimuli, such as stubbing a toe, burning a finger, putting alcohol on a cut, or bumping the "funny bone". Because it is a complex, subjective phenomenon, defining pain has been a challenge. The International Association for the Study of Pain's widely used definition states: "Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." In medical diagnosis, pain is regarded as a symptom of an underlying condition., A disease is a particular abnormal condition, a disorder of a structure or function, that affects part or all of an organism. The study of disease is called pathology which includes the causal study of etiology. Disease is often construed as a medical condition associated with specific symptoms and signs. It may be caused by external factors such as pathogens, or it may be caused by internal dysfunctions particularly of the immune system such as an immunodeficiency, or a hypersensitivity including allergies and autoimmunity., Replacement arthroplasty (from Greek "arthron", joint, limb, articulate, + "plassein", to form, mould, forge, feign, make an image of), or joint replacement surgery, is a procedure of orthopedic surgery in which an arthritic or dysfunctional joint surface is replaced with an orthopedic prosthesis. Joint replacement is considered as a treatment when severe joint pain or dysfunction is not alleviated by less-invasive therapies. During the latter half of the 20th century, rheumasurgery developed as a subspecialty focused on these and a few other procedures in patients with rheumatic diseases., White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system., Osteoarthritis ( OA ) is a type of joint disease that results from breakdown of joint cartilage and underlying bone . The most common symptoms are joint pain and stiffness . Initially , symptoms may occur only following exercise , but over time may become constant . Other symptoms may include joint swelling , decreased range of motion , and when the back is affected weakness or numbness of the arms and legs . The most commonly involved joints are those near the ends of the fingers , at the base of the thumb , neck , lower back , knees , and hips . Joints on one side of the body are often more affected than those on the other . Usually the problems come on over years . It can affect work and normal daily activities . Unlike other types of arthritis , only the joints are typically affected . Causes include previous joint injury , abnormal joint or limb development , and inherited factors . Risk is greater in those who are overweight , have one leg of a different length , and have jobs that result in high levels of joint stress . Osteoarthritis is believed to be caused by mechanical stress on the joint and low grade inflammatory processes . It develops as cartilage is lost with eventually the underlying bone becoming affected . As pain may make it difficult to exercise , muscle loss may occur . Diagnosis is typically based on signs and symptoms with medical imaging and other tests occasionally used to either support or rule out other problems . Unlike in rheumatoid arthritis , which is primarily an inflammatory condition , the joints do not typically become hot or red . Treatment includes exercise , efforts to decrease joint stress , support groups , and pain medications . Efforts to decrease joint stress include resting and the use of a cane . Weight loss may help in those who are overweight . Pain medications may include paracetamol ( acetaminophen ) . If this does not work NSAIDs such as naproxen may be used , but these medications are associated with greater side effects . Opioids if used are generally only recommended short term due to the risk of addiction . If pain interferes with normal life despite other treatments , joint replacement surgery may help . An artificial joint , however , only lasts a limited amount of time . Outcomes for most people with osteoarthritis are good . OA is the most common form of arthritis with disease of the knee and hip affecting about 3.8 % of people as of 2010 . Among those over 60 years old about 10 % of males and 18 % of females are affected . It is the cause of about 2 % of years lived with disability . In Australia about 1.9 million people are affected , and in the United States about 27 million people are affected . Before 45 years of age it is more common in men , while after 45 years of age it is more common in women . It becomes more common in both sexes as people become older ., Pathology (from the Greek roots of "pathos", meaning "experience" or "suffering", and "-logia", "study of") is a significant component of the causal study of disease and a major field in modern medicine and diagnosis., Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging., Subject: osteoarthritis, Relation: medical_specialty, Options: (A) infection (B) infectious disease (C) orthopedics (D) pathology (E) rheumatology (F) surgery
[A]: rheumatology


[Q]: Context: Russia (from the  Rus'), also officially known as the Russian Federation, is a country in Eurasia. At , Russia is the largest country in the world by surface area, covering more than one-eighth of the Earth's inhabited land area, and the ninth most populous, with over 140 million people at the end of March 2016. The European western part of the country is much more populated and urbanised than the eastern, about 77% of the population live in European Russia. Russia's capital Moscow is one of the largest cities in the world, other major urban centers include Saint Petersburg, Novosibirsk, Yekaterinburg, Nizhny Novgorod and Samara., The BTR-60 is the first vehicle in a series of Soviet eight-wheeled armoured personnel carriers (APCs). It was developed in the late 1950s as a replacement for the BTR-152 and was seen in public for the first time in 1961. BTR stands for "Bronetransporter" (, , literally "armoured transporter")., An armoured fighting vehicle (AFV) is a combat vehicle, protected by strong armour and generally armed with weapons, which combines operational mobility, tactical offensive, and defensive capabilities. AFVs can be wheeled or tracked. It is not uncommon for AFVs to be simply referred to as "armour"., The Eastern Bloc was the group of communist states of Central and Eastern Europe, generally the Soviet Union and the countries of the Warsaw Pact. The terms Communist Bloc and Soviet Bloc were also used to denote groupings of states aligned with the Soviet Union, although these terms might include states outside Central and Eastern Europe., A military operation is the coordinated military actions of a state, or a non-state actor, in response to a developing situation. These actions are designed as a military plan to resolve the situation in the state's favor. Operations may be of a combat or non-combat nature and are referred to by a code name for the purpose of national security. Military operations are often known for their more generally accepted common usage names than their actual operational objectives., The ZiS-151 was general-purpose truck produced by the Soviet car manufacturer Automotive Factory No. 2 "Zavod imeni Stalina" in 19471958. In 1956, the factory was renamed to "Zavod imeni Likhacheva", and new trucks were called ZiL-151., The BTR-152 (also known as BTR-140) was a six-wheeled Soviet armored personnel carrier (, from /"Bronetransporter", literally "armored transporter") , built on the chassis and drive train of a ZiS-151 utility truck. It entered service with a number of Warsaw Pact member states beginning in 1950, and formed the mainstay of Soviet motor rifle battalions until the advent of the amphibious BTR-60 series during the 1960s., In military operations, reconnaissance is the exploration outside an area occupied by friendly forces to gain information about natural features and enemy presence., The BRDM-2 ("Boyevaya Razvedyvatelnaya Dozornaya Mashina",    , literally "Combat Reconnaissance/Patrol Vehicle") is an amphibious armoured patrol car used by Russia and the former Soviet Union. It was also known under the designations BTR-40PB, BTR-40P-2 and GAZ 41-08. This vehicle, like many other Soviet designs, has been exported extensively and is in use in at least 38 countries. It was intended to replace the earlier BRDM-1, compared to which it had improved amphibious capabilities and better armament., BRDM is an initialism for "Boyevaya Razvedyvatelnaya Dozornaya Mashina", (RU    ), literally "Combat Reconnaissance Patrol Vehicle". The BRDM is a four-wheeled amphibious vehicle which is very lightly armoured by today's standards. Both versions were produced in the Soviet Union and other Eastern Bloc countries. Both versions came in an ATGM variant. The BRDM-2 also came as a command vehicle and as an air defence vehicle., The BRDM-1 ("Bronirovannaya Razvedyvatelnaya Dozornaya Mashina",    , literally "Armored reconnaissance/patrol vehicle") was an amphibious armored scout car used by Russia and the former Soviet Union. It was originally known simply as BRDM but when the BRDM-2 entered production and service with Soviet Army in 1962, it received the designation BRDM-1. The BRDM (also known as the BTR-40P) first appeared in 1957, and was in production until 1966. Total production was around 10,000 vehicles, less than 600 remain in the reserves of a number of countries., An armoured personnel carrier (APC) is a type of armoured fighting vehicle (AFV) designed to transport infantry to the battlefield. APCs are colloquially referred to as 'battle taxis' or 'battle buses', among other things. Armoured personnel carriers are distinguished from infantry fighting vehicles by the weaponry they carry., Infantry is the general branch of an army that engages in military combat on foot. As the troops who engage with the enemy in close-ranged combat, infantry units bear the largest brunt of warfare and typically suffer the greatest number of casualties during a military campaign. Historically, as the oldest branch of the combat arms, the infantry are the tip of the spear of a modern army, and continually undergo training that is typically more physically demanding and psychologically stressful than that of any other branch of the combat arms. Common representations of infantry fighting forces include the U.S. Army Infantry Branch, U.S. Marine Corps Infantry, Royal Canadian Infantry Corps, Infantry of the British Army, and the Royal Australian Corps of Infantry., The Warsaw Pact, formally the Treaty of Friendship, Co-operation, and Mutual Assistance and sometimes, informally, WarPac. was a collective defense treaty among the Soviet Union and seven other Soviet satellite states in Central and Eastern Europe in existence during the Cold War. The Warsaw Pact was the military complement to the Council for Mutual Economic Assistance (CoMEcon), the regional economic organization for the communist states of Central and Eastern Europe. The Warsaw Pact was created in reaction to the integration of West Germany into NATO in 1955 per the London and Paris Conferences of 1954, but it is also considered to have been motivated by Soviet desires to maintain control over military forces in Central and Eastern Europe., The BTR - 40 (  , from  , or Bronetransporter , literally `` armoured transporter '' .  ) is a Soviet non-amphibious , wheeled armoured personnel carrier and reconnaissance vehicle . It is often referred to as the Sorokovka in Soviet service . It is also the first mass - produced Soviet APC . It was eventually replaced in the APC role by the BTR - 152 and in the scout car role by the BRDM - 1 ., The Soviet Union, officially the Union of Soviet Socialist Republics (USSR " ) was a socialist state in Eurasia that existed from 1922 to 1991. A union of multiple subnational republics, its government and economy were highly centralized. The Soviet Union was a one-party federation, governed by the Communist Party with Moscow as its capital., An infantry fighting vehicle (IFV), or mechanized infantry combat vehicle (MICV), is a type of armoured fighting vehicle used to carry infantry into battle and provide direct fire support. The Treaty on Conventional Armed Forces in Europe defines an infantry fighting vehicle as "an armoured combat vehicle which is designed and equipped primarily to transport a combat infantry squad, which is armed with an integral or organic cannon of at least 20 millimeters calibre and sometimes an antitank missile launcher.", Subject: btr-40, Relation: instance_of, Options: (A) 1 (B) armored personnel carrier (C) armour (D) bear (E) branch (F) calibre (G) campaign (H) cannon (I) capital (J) chassis (K) collective (L) combat (M) communist party (N) corps (O) council (P) country (Q) designation (R) eight (S) exploration (T) factory (U) federation (V) four (W) government (X) group (Y) infantry (Z) infantry fighting vehicle ([) information (\) initialism (]) march (^) may (_) member (`) military (a) military campaign (b) military operation (c) number (d) operation (e) pact (f) party (g) plan (h) population (i) public (j) reconnaissance (k) reconnaissance vehicle (l) role (m) saint (n) series (o) service (p) six (q) soviet (r) state (s) surface (t) time (u) training (v) treaty (w) truck (x) vehicle
[A]:
armored personnel carrier