Please answer the following question: Information:  - A university system is a set of multiple, affiliated universities and colleges that are usually geographically distributed. Typically, all member universities in a university system share a common component among all of their various names. Usually, all member universities of a university system are governed by a system-wide governing body, such as a board of trustees or a board of regents. In fact, university systems are so common in post-World War II United States that most states have one or two state university systems under which many of their publicly funded universities are aligned, both in name and in governance. Additionally, for-profit universities, such as DeVry University, often have multiple campuses which share the same name; these may be, but are not always, described as a university system (not necessarily accurately, see below).  - The University of the Philippines Manila (also referred to as UPM or UP Manila) is a coeducational and public research university in the Philippines. Located in Manila, the country's capital city, it is the oldest of the seven constituent universities of the University of the Philippines system. Its oldest degree-granting unit is the College of Medicine, which was founded in 1905 as the Philippine Medical School, predating the founding of UP by three years.  - A national university is generally a university created or managed by a government, but which may at the same time operate autonomously without direct control by the state.  - The University of the Philippines Manila - College of Arts and Sciences is the largest college by population of the University of the Philippines Manila , one of the constituent universities of the University of the Philippines System . The college offers subjects under the general education curriculum . It provides education to around 1,200 non-CAS students and 1,700 CAS students annually . It is the college which offers the most number of subjects every semester .  - The University of the Philippines (UP; Filipino: "Unibersidad ng Pilipinas" or "Pamantasan ng Pilipinas") is a public university system in the Philippines. Founded by the American colonial government on June 18, 1908, it was originally a university conceived for the Filipinos. Act 1870 of the 1st Philippine Legislature was signed to establish UP to provide "advanced instruction in literature, philosophy, the sciences and arts, and to give professional and technical training" to eligible students regardless of "age, sex, nationality, religious belief and political affiliation". UP has institutional autonomy as the country's national university as mandated by Republic Act No. 9500 (UP Charter of 2008).  - Filipinos are the people who are native to, or identified with the country of the Philippines. The people of the Philippines come from various ethnolinguistic groups, with the vast majority of Filipinos being of Austronesian stock.  - Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe.  - The Philippines, officially the Republic of the Philippines, is a sovereign island country in Southeast Asia situated in the western Pacific Ocean. It consists of about 7,641 islands that are categorized broadly under three main geographical divisions from north to south: Luzon, Visayas, and Mindanao. The capital city of the Philippines is Manila and the most populous city is Quezon City, both part of Metro Manila. Bounded by the South China Sea on the west, the Philippine Sea on the east and the Celebes Sea on the southwest, the Philippines shares maritime borders with Taiwan to the north, Vietnam to the west, Palau to the east and Malaysia and Indonesia to the south.  - Manila (or ), officially City of Manila, is the capital of the Philippines.  - The First Philippine Legislature was the first session of the Philippine Legislature, the first representative legislature of the Philippines. Then known as the Philippine Islands, the Philippines under the sovereign control of the United States through the Insular Government. The Philippine Legislature consisted of an appointed upper house, the Philippine Commission and an elected lower house, the Philippine Assembly. These bodies were the predecessors of the Philippine Senate and Philippine House of the Philippine Congress.    Given the paragraphs above, decide what entity has the relation 'instance of' with 'medical school'.
A:
university of the philippines manila college of arts and sciences