Definition: In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).
Input: Context: Atomic TV was a channel launched in 1997 in Poland ( in 1996 - 1997 aired as programming block in polish cable station PTK2 ) . It originated in music and music videos . It was closed in 2000 and was replaced by MTV Poland ., A gene is a locus (or region) of DNA which is made up of nucleotides and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as geneenvironment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life., Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.
Risk factors for developing breast cancer include being female, obesity, lack of physical exercise, drinking alcohol, hormone replacement therapy during menopause, ionizing radiation, early age at first menstruation, having children late or not at all, older age, and family history. About 510% of cases are due to genes inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply the ducts with milk. Cancers developing from the ducts are known as ductal carcinomas, while those developing from lobules are known as lobular carcinomas. In addition, there are more than 18 other sub-types of breast cancer. Some cancers, such as ductal carcinoma in situ, develop from pre-invasive lesions. The diagnosis of breast cancer is confirmed by taking a biopsy of the concerning lump. Once the diagnosis is made, further tests are done to determine if the cancer has spread beyond the breast and which treatments it may respond to.
The balance of benefits versus harms of breast cancer screening is controversial. A 2013 Cochrane review stated that it is unclear if mammographic screening does more good or harm. A 2009 review for the US Preventive Services Task Force found evidence of benefit in those 40 to 70 years of age, and the organization recommends screening every two years in women 50 to 74 years old. The medications tamoxifen or raloxifene may be used in an effort to prevent breast cancer in those who are at high risk of developing it. Surgical removal of both breasts is another preventative measure in some high risk women. In those who have been diagnosed with cancer, a number of treatments may be used, including surgery, radiation therapy, chemotherapy, hormonal therapy and targeted therapy. Types of surgery vary from breast-conserving surgery to mastectomy. Breast reconstruction may take place at the time of surgery or at a later date. In those in whom the cancer has spread to other parts of the body, treatments are mostly aimed at improving quality of life and comfort.
Outcomes for breast cancer vary depending on the cancer type, extent of disease, and person's age. Survival rates in the developed world are high, with between 80% and 90% of those in England and the United States alive for at least 5 years. In developing countries survival rates are poorer. Worldwide, breast cancer is the leading type of cancer in women, accounting for 25% of all cases. In 2012 it resulted in 1.68 million cases and 522,000 deaths. It is more common in developed countries and is more than 100 times more common in women than in men., MTV (originally an initialism of Music Television) is an American cable and satellite television channel owned by Viacom Media Networks (a division of Viacom) and headquartered in New York City. Launched on August 1, 1981, the channel originally aired music videos as guided by television personalities known as "video jockeys" (VJs). In its early years, MTV's main target demographic was young adults, but today it is primarily towards teenagers, high school students and college students. MTV has toned down its music video programming significantly in recent years, and its programming now consists mainly of original reality, comedy and drama programming and some off-network syndicated programs and films, with limited music video programming in off-peak time periods. It has received criticism towards this change of focus, both by certain segments of its audience and musicians. MTV's influence on its audience, including issues involving censorship and social activism, has also been a subject of debate for several years., PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the "PTK2" gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility., A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase., Proteins (or ) are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity., In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the substrate gains a phosphate group and the high-energy ATP molecule donates a phosphate group. This transesterification produces a phosphorylated substrate and ADP. Conversely, it is referred to as dephosphorylation when the phosphorylated substrate donates a phosphate group and ADP gains a phosphate group (producing a dephosphorylated substrate and the high energy molecule of ATP). These two processes, phosphorylation and dephosphorylation, occur four times during glycolysis. Kinases are part of the larger family of phosphotransferases. Kinases are not to be confused with phosphorylases, which catalyze the addition of inorganic phosphate groups to an acceptor, nor with phosphatases, which remove phosphate groups. The phosphorylation state of a molecule, whether it be a protein, lipid, or carbohydrate, can affect its activity, reactivity, and its ability to bind other molecules. Therefore, kinases are critical in metabolism, cell signalling, protein regulation, cellular transport, secretory processes, and many other cellular pathways., In cell biology, focal adhesions (also cellmatrix adhesions or FAs) are large macromolecular assemblies through which mechanical force and regulatory signals are transmitted between the extracellular matrix (ECM) and an interacting cell. More precisely, focal adhesions are the sub-cellular structures that mediate the regulatory effects (i.e., signaling events) of a cell in response to ECM adhesion., MTV Polska is the Polish version of the international music channel MTV. It was launched on July 7, 2000 and replaced the music channel Atomic TV after it was purchased by MTV Networks Europe. It is currently operated by Warsaw-based MTV Networks Polska (which runs also VIVA and VH1 Polska) and is available on cable and digital satellite television. It airs both American and European (mainly British) MTV shows, as well as local production., Warsaw (; see also other names) is the capital and largest city of Poland. It stands on the Vistula River in east-central Poland, roughly from the Baltic Sea and from the Carpathian Mountains. Its population is estimated at 1.750 million residents within a greater metropolitan area of 3.105 million residents, which makes Warsaw the 9th most-populous capital city in the European Union. The city limits cover , while the metropolitan area covers ., Subject: atomic tv, Relation: instance_of, Options: (A) 1 (B) acid (C) activity (D) alcohol (E) amino acid (F) august (G) biology (H) capital (I) cell (J) censorship (K) change (L) channel (M) city (N) college (O) dna (P) energy (Q) england (R) environment (S) enzyme (T) family (U) force (V) four (W) gene (X) good (Y) high school (Z) history ([) hormone (\) inheritance (]) initialism (^) limited (_) may (`) metropolitan (a) music (b) music television (c) number (d) organism (e) patch (f) phosphate (g) production (h) programming (i) protein (j) quality (k) satellite television (l) school (m) sea (n) shape (o) skin (p) state (q) surgery (r) task force (s) television (t) television channel (u) therapy (v) three (w) time (x) tissue
Output:
television channel