In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).

Context: Hurricane Georges was a powerful and long-lived Cape Verde-type Category 4 hurricane which caused severe destruction as it traversed the Caribbean and Gulf of Mexico in September 1998, making seven landfalls along its path. Georges was the seventh tropical storm, fourth hurricane, and second major hurricane of the 1998 Atlantic hurricane season. It became the second most destructive storm of the season after Hurricane Mitch, the costliest Atlantic hurricane since Hurricane Andrew in 1992, and the deadliest since Hurricane Gordon in 1994. Georges killed 604 people, mainly on the island of Hispaniola, and caused extensive damage resulting at just under $10 billion (1998 US dollars, $  USD) in damages mostly in St. Kitts and Nevis, Puerto Rico and Hispaniola., The Gulf of Mexico is an ocean basin largely surrounded by the North American continent. It is bounded on the northeast, north and northwest by the Gulf Coast of the United States, on the southwest and south by Mexico, and on the southeast by Cuba. The U.S. states of Alabama, Florida, Louisiana, Mississippi and Texas border the Gulf on the north, which are often referred to as the "Third Coast" in comparison with the U.S. Atlantic and Pacific coasts, or sometimes the "south coast", in juxtaposition to the Great Lakes region being the "north coast." One of the gulf's seven main areas is the Gulf of Mexico basin., Nevis is a small island in the Caribbean Sea that forms part of the inner arc of the Leeward Islands chain of the West Indies. Nevis and the neighbouring island of Saint Kitts constitute one country: the Federation of Saint Kitts and Nevis. Nevis is located near the northern end of the Lesser Antilles archipelago, about 350 km east-southeast of Puerto Rico and 80 km west of Antigua. Its area is and the capital is Charlestown., Puerto Rico, (Spanish for "Rich Port") officially the Commonwealth of Puerto Rico ("Free Associated State of Puerto Rico") and briefly called Porto Rico, is an unincorporated territory of the United States located in the northeast Caribbean Sea., The Mississippi River is the chief river of the largest drainage system on the North American continent. Flowing entirely in the United States (although its drainage basin reaches into Canada), it rises in northern Minnesota and meanders slowly southwards for to the Mississippi River Delta at the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains all or parts of 31 U.S. states and 2 Canadian provinces between the Rocky and Appalachian Mountains. The Mississippi ranks as the fourth longest and fifteenth largest river in the world by discharge. The river either borders or passes through the states of Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana., The Caribbean (or ) is a region that consists of the Caribbean Sea, its islands (some surrounded by the Caribbean Sea and some bordering both the Caribbean Sea and the North Atlantic Ocean) and the surrounding coasts. The region is southeast of the Gulf of Mexico and the North American mainland, east of Central America, and north of South America., Hurricane Mitch was the most powerful and destructive hurricane of the 1998 Atlantic hurricane season, with maximum sustained winds of . The storm was the thirteenth tropical storm, ninth hurricane, and third major hurricane of the season. Along with Hurricane Georges, Mitch was the most notable hurricane in the season. At the time, Hurricane Mitch was the strongest Atlantic hurricane observed in the month of October, though it has since been surpassed by Hurricane Wilma of the 2005 season. The hurricane matched the fourth most intense Atlantic hurricane on record (it has since dropped to seventh)., Hispaniola (Spanish: "La Española"; Latin: "Hispaniola"; Taíno: "Haiti") is the 22nd-largest island in the world, located in the Caribbean island group, the Greater Antilles. It is the second largest island in the Caribbean after Cuba, and the tenth most populous island in the world., The effects of Hurricane Georges in Mississippi included $ 676.8 million in damages but no fatalities . Hurricane Georges was a Category 2 storm in the 1998 Hurricane season ., The 1998 Atlantic hurricane season was one of the deadliest and costliest Atlantic hurricane seasons that featured the highest number of storm-related fatalities in over 200 years. It officially began on June 1 and ended on November 30, dates which conventionally delimit the period during which most tropical cyclones form in the Atlantic Ocean. The first tropical cyclone, Tropical Storm Alex, developed on July 27, and the season's final storm, Hurricane Nicole, became extratropical on December 1. The strongest storm, Mitch, was tied with Hurricane Dean for the seventh most intense Atlantic hurricane ever recorded. Mitch is also the second deadliest Atlantic hurricane in recorded history. The system dropped tremendous amounts of rainfall in Central America, causing 19,000 confirmed deaths and at least $6.2 billion (1998 USD) in damage. The season was the first since Hurricane Andrew in the 1992 season to feature a Category 5 hurricane on the SaffirSimpson hurricane wind scale. , Mississippi is a state in the southern region of the United States, with part of its southern border formed by the Gulf of Mexico. Its western border is formed by the Mississippi River., Subject: effects of hurricane georges in mississippi, Relation: instance_of, Options: (A) 1 (B) atlantic hurricane (C) border (D) cape (E) category (F) coast (G) continent (H) country (I) cyclone (J) damage (K) drainage (L) drainage basin (M) federation (N) gulf (O) island (P) july (Q) number (R) ocean (S) part (T) port (U) region (V) river (W) river delta (X) sea (Y) season (Z) september ([) state (\) storm (]) system (^) territory (_) territory of the united states (`) time (a) tropical cyclone (b) unincorporated territory (c) wind
cyclone

Context: France, officially the French Republic, is a country with territory in western Europe and several overseas regions and territories. The European, or metropolitan, area of France extends from the Mediterranean Sea to the English Channel and the North Sea, and from the Rhine to the Atlantic Ocean. Overseas France include French Guiana on the South American continent and several island territories in the Atlantic, Pacific and Indian oceans. France spans and had a total population of almost 67 million people as of January 2017. It is a unitary semi-presidential republic with the capital in Paris, the country's largest city and main cultural and commercial centre. Other major urban centres include Marseille, Lyon, Lille, Nice, Toulouse and Bordeaux., Gaul (Latin: "Gallia") was a region of Western Europe during the Iron Age that was inhabited by Celtic tribes, encompassing present day France, Luxembourg, Belgium, most of Switzerland, Northern Italy, as well as the parts of the Netherlands, Central Italy and Germany on the west bank of the Rhine. It covered an area of 190,800 mi² or 494,169 km². According to the testimony of Julius Caesar, Gaul was divided into three parts: Gallia Celtica, Belgica and Aquitania.
Archaeologically, the Gauls were bearers of the La Tène culture, which extended across all of Gaul, as well as east to Raetia, Noricum, Pannonia and southwestern Germania during the 5th to 1st centuries BC.
During the 2nd and 1st centuries BC, Gaul fell under Roman rule: Gallia Cisalpina was conquered in 203 BC and Gallia Narbonensis in 123 BC. Gaul was invaded after 120 BC by the Cimbri and the Teutons, who were in turn defeated by the Romans by 103 BC. Julius Caesar finally subdued the remaining parts of Gaul in his campaigns of 58 to 51 BC., Pelagianism is the belief that original sin did not taint human nature and that mortal will is still capable of choosing good or evil without special divine aid. This theological theory is named after the British monk Pelagius (354420 or 440), although he denied, at least at some point in his life, many of the doctrines associated with his name. Pelagius taught that the human will, as created with its abilities by God, was sufficient to live a sinless life, although he believed that God's grace assisted every good work. Pelagianism has come to be identified with the view (whether taught by Pelagius or not) that human beings can earn salvation by their own efforts., Canonization is the act by which the Catholic Church and Anglican Communion declare that a person who has died was a saint, upon which declaration the person is included in the canon, or list, of recognized saints. Originally, people were recognized as saints without any formal process. Later, different processes, such as those used today in the Eastern Orthodox Church and Roman Catholic Church, were developed., Italy, officially the Italian Republic, is a unitary parliamentary republic in Europe. Located in the heart of the Mediterranean Sea, Italy shares open land borders with France, Switzerland, Austria, Slovenia, San Marino and Vatican City. Italy covers an area of and has a largely temperate seasonal climate and Mediterranean climate; due to its shape, it is often referred to in Italy as "lo Stivale" (the Boot). With 61 million inhabitants, it is the fourth most populous EU member state., Saint Alban is venerated as the first recorded British Christian martyr, and is considered to be the British protomartyr. Along with his fellow saints "Amphibalus," Julius, and Aaron, Alban is one of four named martyrs recorded from Roman Britain. He is traditionally believed to have been beheaded in the Roman city of Verulamium (modern St Albans) sometime during the 3rd or 4th century, and his cult has been celebrated there since ancient times., Constrained Energy Lapped Transform (CELT) is an open, royalty-free lossy audio compression format and a free software codec with especially low algorithmic delay for use in low-latency audio communication. The algorithms are openly documented and may be used free of software patent restrictions. Development of the format was maintained by the Xiph.Org Foundation (as part of the Ogg codec family) and later coordinated by the Opus working group of the Internet Engineering Task Force (IETF)., The Netherlands  is the main constituent country of the Kingdom of the Netherlands. It is a densely populated country located in Western Europe with three island territories in the Caribbean. The European part of the Netherlands borders Germany to the east, Belgium to the south, and the North Sea to the northwest, sharing maritime borders with Belgium, the United Kingdom, and Germany. The largest cities in the Netherlands are Amsterdam, Rotterdam, The Hague and Utrecht. Amsterdam is the country's capital, while The Hague holds the Dutch seat of government and parliament. The name "Holland" is used to refer informally to the whole of the country of the Netherlands., Glorification may have several meanings in the Christian religion. From the Catholic canonization to the similar sainthood of the Eastern Orthodox Church to the salvation in Protestant beliefs, the glorification of the human condition can be a long and arduous process., Belgium , officially the Kingdom of Belgium, is a sovereign state in Western Europe bordered by France, the Netherlands, Germany, Luxembourg, and the North Sea. It is a small, densely populated country which covers an area of and has a population of about 11 million people. Straddling the cultural boundary between Germanic and Latin Europe, Belgium is home to two main linguistic groups: the Dutch-speaking, mostly Flemish community, which constitutes about 59% of the population, and the French-speaking, mostly Walloon population, which comprises 41% of all Belgians. Additionally, there is a small group of German-speakers who live in the East Cantons located around the High Fens area, and bordering Germany., The Cimbri were an ancient people, either Germanic or Celtic who, together with the Teutones and the Ambrones, fought the Roman Republic between 113 and 101 BC. The Cimbri were initially successful, particularly at the Battle of Arausio, in which a large Roman army was routed, after which they raided large areas in Gaul and Hispania. In 101 BC, during an attempted invasion of Italy, the Cimbri were decisively defeated by Gaius Marius, and their king, Boiorix, was killed. Some of the surviving captives are reported to have been among the rebelling Gladiators in the Third Servile War., Evil, in a general context, is the absence or opposite of that which is described as being good. Often, evil is used to denote profound immorality. In certain religious contexts, evil has been described as a supernatural force. Definitions of evil vary, as does the analysis of its motives. However, elements that are commonly associated with evil involve unbalanced behavior involving expediency, selfishness, ignorance, or neglect., Pelagius (360  418 AD) was a British-born ascetic moralist, who became well known throughout the Roman Empire in Late Antiquity. He opposed the idea of predestination and asserted a strong version of the doctrine of free will. He was accused by Augustine of Hippo and others of denying the need for divine aid in performing good works. They understood him to have said that the only grace necessary was the declaration of the law; humans were not wounded by Adam's sin and were perfectly able to fulfill the law without divine aid. Pelagius denied Augustine's theory of original sin. His adherents cited Deuteronomy 24:16 in support of their position. Pelagius was declared a heretic by the Council of Carthage. His interpretation of a doctrine of free will became known as Pelagianism., A Christian (or ) is a person who follows or adheres to Christianity, an Abrahamic, monotheistic religion based on the life and teachings of Jesus Christ. "Christian" derives from the Koine Greek word "Christós" (), a translation of the Biblical Hebrew term "mashiach"., Veneration (Latin "veneratio" or "dulia", Greek , "douleia"), or veneration of saints, is the act of honoring a saint, a person who has been identified as having a high degree of sanctity or holiness. Angels are shown similar veneration in many religions. Philologically, "to venerate" derives from the Latin verb, "venerare", meaning to regard with reverence and respect. Veneration of saints is practiced, formally or informally, by adherents of some branches of all major religions, including Christianity, Judaism, Hinduism, Islam, and Buddhism., Germany, officially the Federal Republic of Germany, is a federal parliamentary republic in central-western Europe. It includes 16 constituent states, covers an area of , and has a largely temperate seasonal climate. With about 82 million inhabitants, Germany is the most populous member state of the European Union. After the United States, it is the second most popular immigration destination in the world. Germany's capital and largest metropolis is Berlin. Other major cities include Hamburg, Munich, Cologne, Frankfurt, Stuttgart and Düsseldorf., Saint Amphibalus is a venerated early Christian priest who is said to have converted Saint Alban to Christianity, and, although his identity and historicity are dubious, he at one point occupied a place in British hagiography almost as revered as Saint Alban himself. According to many hagiographical accounts, including those of Gildas, Bede, Geoffrey of Monmouth, and Matthew of Paris, Amphibalus was a Roman Christian fleeing the religious persecution under Emperor Diocletian. While in the Roman city of Verulamium, in modern day England, Saint Amphibalus was offered shelter by Saint Alban, who was so impressed with the priest's faith and teaching that Alban began to emulate him in worship and eventually became a Christian himself. When Roman soldiers came to seize St. Amphibalus, Alban put on Amphibalus' robes and was punished in his stead. According to Matthew Paris, after St. Alban's martyrdom, the Romans eventually caught and martyred Amphibalus, too., A saint, also historically known as a hallow, is a term used for a person who is recognized as having an exceptional degree of holiness or likeness to God. Depending on the context and denomination, the term also retains its original Christian meaning, as any believer who is "in Christ" and in whom Christ dwells, whether in Heaven or on Earth. In Anglican, Roman Catholic, Eastern Orthodox, Lutheran, and Oriental Orthodox doctrine, all of their faithful deceased in Heaven are considered to be saints, but some are considered worthy of greater honor or emulation; official ecclesiastical recognition, and consequently veneration, is given to some saints through the process of canonization in the Catholic Church or glorification in the Eastern Orthodox Church., The Iron Age is an archaeological era, referring to a period of time in the prehistory and protohistory of the Old World (Afro-Eurasia) when the dominant toolmaking material was iron. It is commonly preceded by the Bronze Age in Europe and Asia with exceptions and the Stone Age in Africa. Meteoric iron has been used by humans since at least 3200 BC, but ancient iron production did not become widespread until the ability to smelt iron ore, remove impurities and regulate the amount of carbon in the alloy were developed. The start of the Iron Age proper is considered by many to fall between around 1200 BC to 600 BC, depending on the region. In most parts of the world, its end is defined by the widespread adoption of writing, and therefore marks the transition from prehistory to history., Germanus of Auxerre ( Welsh : Garmon Sant ) ( c. 378 -- c. 448 ) was a bishop of Auxerre in Late Antique Gaul . He is best remembered for his journey to combat Pelagianism in Britain in or around 429 AD , and the records of this visit provide valuable information on the state of post-Roman British society . He also played an important part in the invention and promotion of the Cult of Saint Alban , who was unknown before the saint revealed himself to Germanus in a dream or holy vision . Germanus is venerated as a saint in both the Roman Catholic and Orthodox churches , which commemorate him on July 31 . The principal source for the events of his life is the Vita Germani , a hagiography written by Constantius of Lyon around 480 , and the Passio Albani , which may possibly have been written or commissioned by Germanus . Constantius was a friend of Bishop Lupus of Troyes , who accompanied Germanus to Britain , which provided him with a link to Germanus ., Human nature refers to the distinguishing characteristics which humans tend to have naturally and their actions. Human is defined with three main abilities; to "think, wish and feel". They are expressed in three main areas of human existence and have their appropriate ideals; science ("truth"), arts ("beauty") and religion ("goodness"). Jesus Christ alludes on them when mentions "mind, soul and heart" in Greatest Commandment. In search for ideals and meaning, perversion can mislead human into vices of egoism (might / success), materialism (wealth / money) and hedonism (satisfaction / pleasure). These were also temptations Jesus had to reject before started his public life and ministry. He confronted temptation with three human or cardinal virtues; fortitude ("courage"), temperance ("self-control") and prudence ("caution") and with 
three theological virtues; "faith, hope and love" which relate directly to God who is True, Beauty and Goodness., The Eastern Orthodox Church, also known as the Orthodox Church, or officially as the Orthodox Catholic Church, is the second largest Christian church and one of the oldest current religious institutions in the world. The Eastern Orthodox Church teaches that it is the One, Holy, Catholic and Apostolic Church established by Jesus Christ in his Great Commission to the apostles. It practices what it understands to be the original Christian faith and maintains the sacred tradition passed down from the apostles., Heaven, the heavens or seven heavens, is common religious, cosmological, or transcendent place where beings such as gods, angels, jinn, saints, or venerated ancestors are said to originate, be enthroned, or to live. According to the beliefs of some religions, heavenly beings can descend to earth or incarnate, and earthly beings can ascend to Heaven in the afterlife, or in exceptional cases enter Heaven alive., The Catholic Church, also known as the Roman Catholic Church, is the largest Christian church, with more than 1.27 billion members worldwide. As one of the oldest religious institutions in the world, it has played a prominent role in the history of Western civilisation. Headed by the Bishop of Rome, known as the pope, its doctrines are summarised in the Nicene Creed. The Catholic Church is notable within Western Christianity for its sacred tradition and seven sacraments., Gaius Julius Caesar (13 July 100 BC  15 March 44 BC), known as Julius Caesar, was a Roman politician, general, and notable author of Latin prose. He played a critical role in the events that led to the demise of the Roman Republic and the rise of the Roman Empire., St Albans , is a city in Hertfordshire, England, and the major urban area in the City and District of St Albans. It lies east of Hemel Hempstead and west of Hatfield, about north-northwest of London, southwest of Welwyn Garden City and south-southeast of Luton. St Albans was the first major town on the old Roman road of Watling Street for travellers heading north, and it became the Roman city of Verulamium. It is a historic market town and is now a dormitory town within the London commuter belt and the Greater London Built-up Area., Luxembourg, officially the Grand Duchy of Luxembourg, is a landlocked country in western Europe. It is bordered by Belgium to the west and north, Germany to the east, and France to the south. Its capital, Luxembourg City, is, together with Brussels and Strasbourg, one of the three official capitals of the European Union and the seat of the European Court of Justice, the highest juridical authority in the EU. Its culture, people and languages are highly intertwined with its neighbors, making it essentially a mixture of French and Germanic cultures. The repeated invasions by its neighbor countries, especially in World War II, resulted in the country's strong will for mediation between France and Germany and led to the foundation of the European Union., Subject: germanus of auxerre, Relation: occupation, Options: (A) army (B) ascetic (C) bank (D) bishop (E) carbon (F) cardinal (G) commercial (H) engineering (I) general (J) islam (K) justice (L) king (M) major (N) member (O) monk (P) official (Q) politician (R) priest (S) religion (T) religious (U) saint (V) science (W) sovereign (X) translation (Y) united kingdom
priest

Context: A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease. The tissue is generally examined under a microscope by a pathologist, and can also be analyzed chemically. When an entire lump or suspicious area is removed, the procedure is called an excisional biopsy. When only a sample of tissue is removed with preservation of the histological architecture of the tissues cells, the procedure is called an incisional biopsy or core biopsy. When a sample of tissue or fluid is removed with a needle in such a way that cells are removed without preserving the histological architecture of the tissue cells, the procedure is called a needle aspiration biopsy. Biopsies are most commonly performed for insight into possible cancerous and inflammatory conditions., Colorectal cancer (CRC), also known as bowel cancer, is the development of cancer from the colon or rectum (parts of the large intestine). A cancer is the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and feeling tired all the time.
Most colorectal cancers are due to old age and lifestyle factors with only a small number of cases due to underlying genetic disorders. Some risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red and processed meat as well as alcohol. Another risk factor is inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. It typically starts as a benign tumor, often in the form of a polyp, which over time becomes cancerous.
Bowel cancer may be diagnosed by obtaining a sample of the colon during a sigmoidoscopy or colonoscopy. This is then followed by medical imaging to determine if the disease has spread. Screening is effective for preventing and decreasing deaths from colorectal cancer. Screening is recommended starting from the age of 50 to 75. During colonoscopy, small polyps may be removed if found. If a large polyp or tumor is found, a biopsy may be performed to check if it is cancerous. Aspirin and other non-steroidal anti-inflammatory drugs decrease the risk. Their general use is not recommended for this purpose, however, due to side effects.
Treatments used for colorectal cancer may include some combination of surgery, radiation therapy, chemotherapy and targeted therapy. Cancers that are confined within the wall of the colon may be curable with surgery while cancer that has spread widely are usually not curable, with management being directed towards improving quality of life and symptoms. Five year survival rates in the United States are around 65%. This, however, depends on how advanced the cancer is, whether or not all the cancer can be removed with surgery, and the person's overall health. Globally, colorectal cancer is the third most common type of cancer making up about 10% of all cases. In 2012, there were 1.4 million new cases and 694,000 deaths from the disease. It is more common in developed countries, where more than 65% of cases are found. It is less common in women than men., Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging., The National Football League (NFL) is a professional American football league consisting of 32 teams, divided equally between the National Football Conference (NFC) and the American Football Conference (AFC). The NFL is one of the four major professional sports leagues in North America, and the highest professional level of American football in the world. The NFL's 17-week regular season runs from the week after Labor Day to the week after Christmas, with each team playing 16 games and having one bye week. Following the conclusion of the regular season, six teams from each conference (four division winners and two wild card teams) advance to the playoffs, a single-elimination tournament culminating in the Super Bowl, played between the champions of the NFC and AFC., Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and feeling tired. Other symptoms may include bone pain, chest pain, or itchiness. Some forms are slow growing while others are fast growing.
Lymphomas are types of cancer that develops from lymphocytes, a type of white blood cell. Risk factors include poor immune function, autoimmune diseases, "Helicobacter pylori" infection, hepatitis C, obesity, and "Epstein-Barr virus" infection. The World Health Organization (WHO) classifies lymphomas into five major groups, including one for Hodgkin's lymphoma. Within the four groups for NHL there are over 60 specific types of lymphoma. Diagnosis is by examination of a bone marrow or lymph node biopsy. Medical imaging is done to help with cancer staging.
Treatment depends on if the lymphoma is slow or fast growing and if it is in one area or many areas. Treatments may include chemotherapy, radiation, immunotherapy, targeted therapy, stem cell transplantation, surgery, or watchful waiting. If the blood becomes overly thick due to antibodies, plasmapheresis may be used. Radiation and some chemotherapy, however, increase the risk of other cancers, heart disease or nerve problems over the subsequent decades.
In 2013 about 2.96 million people had non-Hodgkin lymphoma and 226,000 died. In the United States 2.1% of people are affected at some point in their life. The most common age of diagnosis is between 65 to 75 years old. The percentage of people who survive five years in the United States is 71%., Stomach cancer, also known as gastric cancer, is cancer developing from the lining of the stomach. Early symptoms may include heartburn, upper abdominal pain, nausea and loss of appetite. Later signs and symptoms may include weight loss, yellowing of the skin and whites of the eyes, vomiting, difficulty swallowing, and blood in the stool among others. The cancer may spread from the stomach to other parts of the body, particularly the liver, lungs, bones, lining of the abdomen and lymph nodes.
The most common cause is infection by the bacterium "Helicobacter pylori", which accounts for more than 60% of cases. Certain types of "H. pylori" have greater risks than others. Other common causes include eating pickled vegetables and smoking. About 10% of cases run in families and between 1% and 3% of cases are due to genetic syndromes inherited from a person's parents such as hereditary diffuse gastric cancer. Most cases of stomach cancers are gastric carcinomas. This type can be divided into a number of subtypes. Lymphomas and mesenchymal tumors may also develop in the stomach. Most of the time, stomach cancer develops in stages over years. Diagnosis is usually by biopsy done during endoscopy. This is followed by medical imaging to determine if the disease has spread to other parts of the body. Japan and South Korea, two countries that have high rates of the disease, screen for stomach cancer.
A Mediterranean diet lowers the risk of cancer as does the stopping of smoking. There is tentative evidence that treating "H. pylori" decreases the future risk. If cancer is treated early, many cases can be cured. Treatments may include some combination of surgery, chemotherapy, radiation therapy, and targeted therapy. If treated late, palliative care may be advised. Outcomes are often poor with a less than 10% 5-year survival rate globally. This is largely because most people with the condition present with advanced disease. In the United States 5-year survival is 28% while in South Korea it is over 65% partly due to screening efforts.
Globally stomach cancer is the fifth leading cause of cancer and the third leading cause of death from cancer making up 7% of cases and 9% of deaths. In 2012 it occurred in 950,000 people and caused 723,000 deaths. Before the 1930s in much of the world, including most Western developed countries, it was the most common cause of death from cancer. Rates of death have been decreasing in many areas of the world since then. This is believed to be due to the eating of less salted and pickled foods as a result of the development of refrigeration as a method of keeping food fresh. Stomach cancer occurs most commonly in East Asia and Eastern Europe. It occurs twice as often in males as in females., Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose tissue and/or lean mass, namely bone mineral deposits, muscle, tendon, and other connective tissue. Weight loss can either occur unintentionally due to malnourishment or an underlying disease or arise from a conscious effort to improve an actual or perceived overweight or obese state. "Unexplained" weight loss that is not caused by reduction in calorific intake or exercise is called cachexia and may be a symptom of a serious medical condition. Intentional weight loss is commonly referred to as slimming., The Pittsburgh Steelers are a professional American football team based in Pittsburgh, Pennsylvania. The Steelers compete in the National Football League (NFL), as a member club of the league's American Football Conference (AFC) North division. Founded in , the Steelers are the oldest franchise in the AFC., The five-year survival rate is a type of survival rate for estimating the prognosis of a particular disease, normally calculated from the point of diagnosis. Lead time bias from earlier diagnosis can affect interpretation of the five-year survival rate., Surgery (from the "cheirourgik" (composed of , "hand", and , "work"), via , meaning "hand work") is an ancient medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance or to repair unwanted ruptured areas (for example, a perforated ear drum)., Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology., The Denver Broncos are an American football team based in Denver, Colorado. The Broncos compete in the National Football League (NFL) as a member club of the league's American Football Conference (AFC) West division. The team began play in 1960 as a charter member of the American Football League (AFL) and joined the NFL as part of the merger in 1970. The Broncos are owned by the Pat Bowlen trust. The Broncos have played at Sports Authority Field at Mile High since , after previously playing at Mile High Stadium from 1960 to 2000., Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy. As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering with all rapidly dividing cells (e.g. with traditional chemotherapy). Because most agents for targeted therapy are biopharmaceuticals, the term "biologic therapy" is sometimes synonymous with "targeted therapy" when used in the context of cancer therapy (and thus distinguished from chemotherapy, that is, cytotoxic therapy). However, the modalities can be combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy., Cervical cancer is a cancer arising from the cervix. It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, typically no symptoms are seen. Later symptoms may include abnormal vaginal bleeding, pelvic pain, or pain during sexual intercourse. While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer.
Human papillomavirus (HPV) infection appears to be involved in the development of more than 90% of cases; most people who have had HPV infections, however, do not develop cervical cancer. Other risk factors include smoking, a weak immune system, birth control pills, starting sex at a young age, and having many sexual partners, but these are less important. Cervical cancer typically develops from precancerous changes over 10 to 20 years. About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. Diagnosis is typically by cervical screening followed by a biopsy. Medical imaging is then done to determine whether or not the cancer has spread.
HPV vaccines protect against between two and seven high-risk strains of this family of viruses and may prevent up to 90% of cervical cancers. As a risk of cancer still exists, guidelines recommend continuing regular Pap smears. Other methods of prevention include: having few or no sexual partners and the use of condoms. Cervical cancer screening using the Pap smear or acetic acid can identify precancerous changes which when treated can prevent the development of cancer. Treatment of cervical cancer may consist of some combination of surgery, chemotherapy, and radiotherapy. Five year survival rates in the United States are 68%. Outcomes, however, depend very much on how early the cancer is detected.
Worldwide, cervical cancer is both the fourth-most common cause of cancer and the fourth-most common cause of death from cancer in women. In 2012, an estimated 528,000 cases of cervical cancer occurred, with 266,000 deaths. This is about 8% of the total cases and total deaths from cancer. About 70% of cervical cancers occur in developing countries. In low-income countries, it is the most common cause of cancer death. In developed countries, the widespread use of cervical screening programs has dramatically reduced rates of cervical cancer. In medical research, the most famous cell line known as HeLa was developed from cervical cancer cells of a woman named Henrietta Lacks., A benign tumor is a mass of cells (tumor) that lacks the ability to invade neighboring tissue or metastasize. These characteristics are required for a tumor to be defined as cancerous and therefore benign tumors are non-cancerous. Also, benign tumors generally have a slower growth rate than malignant tumors and the tumor cells are usually more differentiated (cells have normal features). Benign tumors are typically surrounded by an outer surface (fibrous sheath of connective tissue) or remain with the epithelium. Common examples of benign tumors include moles and uterine fibroids., A brain tumor or intracranial neoplasm occurs when abnormal cells form within the brain. There are two main types of tumors: malignant or cancerous tumors and benign tumors. Cancerous tumors can be divided into primary tumors that start within the brain, and secondary tumors that have spread from somewhere else, known as brain metastasis tumors. All types of brain tumors may produce symptoms that vary depending on the part of the brain involved. These symptoms may include headaches, seizures, problem with vision, vomiting, and mental changes. The headache is classically worse in the morning and goes away with vomiting. More specific problems may include difficulty in walking, speaking, and with sensation. As the disease progresses unconsciousness may occur.
The cause of most brain tumors is unknown. Uncommon risk factors include inherited neurofibromatosis, exposure to vinyl chloride, EpsteinBarr virus, and ionizing radiation. The evidence for mobile phones is not clear. The most common types of primary tumors in adults are meningiomas (usually benign), and astrocytomas such as glioblastomas. In children, the most common type is a malignant medulloblastoma. Diagnosis is usually by medical examination along with computed tomography or magnetic resonance imaging. This is then often confirmed by a biopsy. Based on the findings, the tumors are divided into different grades of severity.
Treatment may include some combination of surgery, radiation therapy and chemotherapy. Anticonvulsant medication may be needed if seizures occur. Dexamethasone and furosemide may be used to decrease swelling around the tumor. Some tumors grow gradually, requiring only monitoring and possibly needing no further intervention. Treatments that use a person's immune system are being studied. Outcome varies considerably depending on the type of tumor and how far it has spread at diagnosis. Glioblastomas usually have poor outcomes while meningiomas usually have good outcomes. The average five-year survival rate for brain cancer in the United States is 33%.
Secondary or metastatic brain tumors are more common than primary brain tumors, with about half of metastases coming from lung cancer. Primary brain tumors occur in around 250,000 people a year globally, making up less than 2% of cancers. In children younger than 15, brain tumors are second only to acute lymphoblastic leukemia as a cause of cancer. In Australia the average economic cost of a case of brain cancer is $1.9 million, the greatest of any type of cancer., Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, abdominal pain, and yellow tinged skin occurs. The virus persists in the liver in about 75% to 85% of those initially infected. Early on chronic infection typically has no symptoms. Over many years however, it often leads to liver disease and occasionally cirrhosis. In some cases, those with cirrhosis will develop complications such as liver failure, liver cancer, or esophageal and gastric varices.
HCV is spread primarily by blood-to-blood contact associated with intravenous drug use, poorly sterilized medical equipment, needlestick injuries in healthcare, and transfusions. Using blood screening, the risk from a transfusion is less than one per two million. It may also be spread from an infected mother to her baby during birth. It is not spread by superficial contact. It is one of five known hepatitis viruses: A, B, C, D, and E. Diagnosis is by blood testing to look for either antibodies to the virus or its RNA. Testing is recommended in all people who are at risk.
There is no vaccine against hepatitis C. Prevention includes harm reduction efforts among people who use intravenous drugs and testing donated blood. Chronic infection can be cured about 90% of the time with treatments that include the medications sofosbuvir or simeprevir. Previous to this a combination of peginterferon and ribavirin was used which had a cure rate around 50% and greater side effects. Getting access to the newer treatments however can be expensive. Those who develop cirrhosis or liver cancer may require a liver transplant. Hepatitis C is the leading reason for liver transplantation, though the virus usually recurs after transplantation.
An estimated 130200 million people worldwide are infected with hepatitis C. In 2013 about 11 million new cases occurred. It occurs most commonly in Africa and Central and East Asia. About 343,000 deaths due to liver cancer and 358,000 deaths due to cirrhosis occurred in 2013 due to hepatitis C. The existence of hepatitis C  originally identifiable only as a type of non-A non-B hepatitis  was suggested in the 1970s and proven in 1989. Hepatitis C infects only humans and chimpanzees., Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health. People are generally considered obese when their body mass index (BMI), a measurement obtained by dividing a person's weight by the square of the person's height, is over , with the range defined as overweight. Some East Asian countries use lower values. Obesity increases the likelihood of various diseases, particularly heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis.
Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity, and genetic susceptibility. A few cases are caused primarily by genes, endocrine disorders, medications, or mental illness. The view that obese people eat little yet gain weight due to a slow metabolism is not generally supported. On average, obese people have a greater energy expenditure than their thin counterparts due to the energy required to maintain an increased body mass.
Obesity is mostly preventable through a combination of social changes and personal choices. Changes to diet and exercising are the main treatments. Diet quality can be improved by reducing the consumption of energy-dense foods, such as those high in fat and sugars, and by increasing the intake of dietary fiber. Medications may be taken, along with a suitable diet, to reduce appetite or decrease fat absorption. If diet, exercise, and medication are not effective, a gastric balloon or surgery may be performed to reduce stomach volume or bowel length, leading to feeling full earlier or a reduced ability to absorb nutrients from food.
Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. In 2014, 600 million adults (13%) and 42 million children under the age of five were obese. Obesity is more common in women than men. Authorities view it as one of the most serious public health problems of the 21st century. Obesity is stigmatized in much of the modern world (particularly in the Western world), though it was seen as a symbol of wealth and fertility at other times in history and still is in some parts of the world. In 2013, the American Medical Association classified obesity as a disease., Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) which affects the liver. It can cause both acute and chronic infections. Many people have no symptoms during the initial infection. Some develop a rapid onset of sickness with vomiting, yellowish skin, tiredness, dark urine and abdominal pain. Often these symptoms last a few weeks and rarely does the initial infection result in death. It may take 30 to 180 days for symptoms to begin. In those who get infected around the time of birth 90% develop chronic while less than 10% of those infected after the age of five do. Most of those with chronic disease have no symptoms; however, cirrhosis and liver cancer may eventually develop. These complications result in the death of 15 to 25% of those with chronic disease.
The virus is transmitted by exposure to infectious blood or body fluids. Infection around the time of birth or from contact with other people's blood during childhood is the most frequent method by which hepatitis B is acquired in areas where the disease is common. In areas where the disease is rare, intravenous drug use and sexual intercourse are the most frequent routes of infection. Other risk factors include working in healthcare, blood transfusions, dialysis, living with an infected person, travel in countries where the infection rate is high, and living in an institution. Tattooing and acupuncture led to a significant number of cases in the 1980s; however, this has become less common with improved sterility. The viruses cannot be spread by holding hands, sharing eating utensils, kissing, hugging, coughing, sneezing, or breastfeeding. The infection can be diagnosed 30 to 60 days after exposure. The diagnosis is usually confirmed by testing the blood for parts of the virus and for antibodies against the virus. It is one of five known hepatitis viruses: A, B, C, D, and E.
The infection has been preventable by vaccination since 1982. Vaccination is recommended by the World Health Organization in the first day of life if possible. Two or three more doses are required at a later time for full effect. This vaccine works about 95% of the time. About 180 countries gave the vaccine as part of national programs as of 2006. It is also recommended that all blood be tested for hepatitis B before transfusion and condoms be used to prevent infection. During an initial infection, care is based on the symptoms that a person has. In those who develop chronic disease, antiviral medication such as tenofovir or interferon may be useful; however, these drugs are expensive. Liver transplantation is sometimes used for cirrhosis.
About a third of the world population has been infected at one point in their lives, including 240 million to 350 million who have chronic infections. Another 129 million new infections occurred in 2013. Over 750,000 people die of hepatitis B each year. About 300,000 of these are due to liver cancer. The disease is now only common in East Asia and sub-Saharan Africa where between 5 and 10% of adults are chronically infected. Rates in Europe and North America are less than 1%. It was originally known as "serum hepatitis". Research is looking to create foods that contain HBV vaccine. The disease may affect other great apes as well.
Signs and symptoms.
Acute infection with virus is associated with acute viral hepatitis, an illness that begins with general ill-health, loss of appetite, nausea, vomiting, body aches, mild fever, and dark urine, and then progresses to development of jaundice. It has been noted that itchy skin has been an indication as a possible symptom of all hepatitis virus types. The illness lasts for a few weeks and then gradually improves in most affected people. A few people may have a more severe form of liver disease known as (fulminant hepatic failure) and may die as a result. The infection may be entirely asymptomatic and may go unrecognized., The New York Giants are a professional American football team located in the New York metropolitan area. The Giants compete in the National Football League (NFL) as a member club of the league's National Football Conference (NFC) East division. The team plays its home games in East Rutherford, New Jersey, at MetLife Stadium, which it shares with the New York Jets in a unique arrangement. The Giants hold their summer training camp at the Quest Diagnostics Training Center at the Meadowlands Sports Complex., Lymphoma is a group of blood cell tumors that develop from lymphocytes (a type of white blood cell). The name often refers to just the cancerous ones rather than all such tumors. Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired. The enlarged lymph nodes are usually painless. The sweats are most common at night.
There are dozens of subtypes of lymphomas. The two main categories of lymphomas are Hodgkin's lymphomas (HL) and the non-Hodgkin lymphomas (NHL). The World Health Organization (WHO) includes two other categories as types of lymphoma: multiple myeloma and immunoproliferative diseases. About 90% of lymphomas are non-Hodgkin lymphomas. Lymphomas and leukemias are a part of the broader group of tumors of the hematopoietic and lymphoid tissues.
Risk factors for Hodgkin lymphoma include infection with EpsteinBarr virus and a history of the disease in the family. Risk factors for common types of non-Hodgkin lymphomas include autoimmune diseases, HIV/AIDS, infection with human T-lymphotropic virus, immunosuppressant medications, and some pesticides. Eating large amounts of red meat and tobacco smoking may also increase the risk. Diagnosis, if enlarged lymph nodes are present, is usually by lymph node biopsy. Blood, urine, and bone marrow testing may also be useful in the diagnosis. Medical imaging may then be done to determine if and where the cancer has spread. Lymphoma most often spreads to the lungs, liver, and/or brain.
Treatment may involve one or more of the following: chemotherapy, radiation therapy, targeted therapy, and surgery. In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein. Watchful waiting may be appropriate for certain types. The outcome depends on the subtype with some being curable and treatment prolonging survival in most. The five-year survival rate in the United States for all Hodgkin lymphoma subtypes is 85%, while that for non-Hodgkin lymphomas is 69%. Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths. They make up 34% of all cancers, making them as a group the seventh-most common form. In children, they are the third-most common cancer. They occur more often in the developed world than the developing world., Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a category of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of medical oncology (the medical discipline specifically devoted to pharmacotherapy for cancer)., Clarence Hubert Kay (born July 30, 1961 in Seneca, South Carolina) is a former professional American football player. A 6'2", 237-lb. tight end from the University of Georgia, Kay was selected by the Denver Broncos in the 7th round of the 1984 NFL Draft. Kay played in 9 NFL seasons from 19841992, all with the Broncos., Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumors are cancerous; benign tumors do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans.
Tobacco use is the cause of about 22% of cancer deaths. Another 10% is due to obesity, poor diet, lack of physical activity and drinking alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In the developing world nearly 20% of cancers are due to infections such as hepatitis B, hepatitis C and human papillomavirus (HPV). These factors act, at least partly, by changing the genes of a cell. Typically many genetic changes are required before cancer develops. Approximately 510% of cancers are due to inherited genetic defects from a person's parents. Cancer can be detected by certain signs and symptoms or screening tests. It is then typically further investigated by medical imaging and confirmed by biopsy.
Many cancers can be prevented by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat, and avoiding too much sunlight exposure. Early detection through screening is useful for cervical and colorectal cancer. The benefits of screening in breast cancer are controversial. Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy, and targeted therapy. Pain and symptom management are an important part of care. Palliative care is particularly important in people with advanced disease. The chance of survival depends on the type of cancer and extent of disease at the start of treatment. In children under 15 at diagnosis the five-year survival rate in the developed world is on average 80%. For cancer in the United States the average five-year survival rate is 66%.
In 2012 about 14.1 million new cases of cancer occurred globally (not including skin cancer other than melanoma). It caused about 8.2 million deaths or 14.6% of human deaths. The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. If skin cancer other than melanoma were included in total new cancers each year it would account for around 40% of cases. In children, acute lymphoblastic leukaemia and brain tumors are most common except in Africa where non-Hodgkin lymphoma occurs more often. In 2012, about 165,000 children under 15 years of age were diagnosed with cancer. The risk of cancer increases significantly with age and many cancers occur more commonly in developed countries. Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world. The financial costs of cancer were estimated at $1.16 trillion US dollars per year as of 2010.
Definitions.
Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely., A symptom (from Greek , "accident, misfortune, that which befalls", from , "I befall", from - "together, with" and , "I fall") is a departure from normal function or feeling which is noticed by a patient, reflecting the presence of an unusual state, or of a disease. A symptom is subjective, observed by the patient, and cannot be measured directly, whereas a sign is objectively observable by others. For example, paresthesia is a symptom (only the person experiencing it can directly observe their own tingling feeling), whereas erythema is a sign (anyone can confirm that the skin is redder than usual). Symptoms and signs are often nonspecific, but often combinations of them are at least suggestive of certain diagnoses, helping to narrow down what may be wrong. In other cases they are specific even to the point of being pathognomonic., Vaccination is the administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to a pathogen. Vaccines can prevent or ameliorate morbidity from infection. When a sufficiently large percentage of a population has been vaccinated, this results in herd immunity. The effectiveness of vaccination has been widely studied and verified; for example, the influenza vaccine, the HPV vaccine, and the chicken pox vaccine. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world. The World Health Organization (WHO) reports that licensed vaccines are currently available to prevent or contribute to the prevention and control of twenty-five preventable infections., Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Melanomas typically occur in the skin but may rarely occur in the mouth, intestines, or eye. In women they most commonly occur on the legs, while in men they are most common on the back. Sometimes they develop from a mole with concerning changes including an increase in size, irregular edges, change in color, itchiness, or skin breakdown.
The primary cause of melanoma is ultraviolet light (UV) exposure in those with low levels of skin pigment. The UV light may be from either the sun or from other sources, such as tanning devices. About 25% develop from moles. Those with many moles, a history of affected family members, and who have poor immune function are at greater risk. A number of rare genetic defects such as xeroderma pigmentosum also increase risk. Diagnosis is by biopsy of any concerning skin lesion.
Using sunscreen and avoiding UV light may prevent melanoma. Treatment is typically removal by surgery. In those with slightly larger cancers, nearby lymph nodes may be tested for spread. Most people are cured if spread has not occurred. For those in whom melanoma has spread, immunotherapy, biologic therapy, radiation therapy, or chemotherapy may improve survival. With treatment the five-year survival rates in the United States is 98% among those with localized disease and 17% among those in whom spread has occurred. The likelihood that it will come back or spread depends how thick the melanoma is, how fast the cells are dividing, and whether or not the overlying skin has broken down.
Melanoma is the most dangerous type of skin cancer. Globally, in 2012, it occurred in 232,000 people and resulted in 55,000 deaths. Australia and New Zealand have the highest rates of melanoma in the world. There are also high rates in Northern Europe and North America, while it is less common in Asia, Africa, and Latin America. Melanoma is more common in men than women. Melanoma has become more common since the 1960s in areas that are mostly Caucasian., Super Bowl XXIV was an American football game between the National Football Conference (NFC) champion San Francisco 49ers and the American Football Conference (AFC) champion Denver Broncos to decide the National Football League (NFL) champion for the 1989 season. Played on January 28, 1990, at the Louisiana Superdome in New Orleans, Louisiana, the 49ers defeated the Broncos by the score of 5510, winning their second consecutive Super Bowl, and tying the Pittsburgh Steelers with four Super Bowl victories. San Francisco also became the first team to win back-to-back Super Bowls with two different head coaches; rookie head coach George Seifert took over after Bill Walsh retired after the previous season's Super Bowl., Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to these organisms and the toxins they produce. Infectious disease, also known as transmissible disease or communicable disease, is illness resulting from an infection.
Infections are caused by infectious agents including viruses, viroids, prions, bacteria, nematodes such as parasitic roundworms and pinworms, arthropods such as ticks, mites, fleas, and lice, fungi such as ringworm, and other macroparasites such as tapeworms and other helminths., The New York Jets are a professional American football team located in the New York metropolitan area. The Jets compete in the National Football League (NFL) as a member club of the league's American Football Conference (AFC) East division. The team is headquartered in Florham Park, New Jersey. In a unique arrangement for the league, the Jets share MetLife Stadium in East Rutherford, New Jersey with the New York Giants. The franchise is legally and corporately registered as New York Jets, LLC., Skin cancers are cancers that arise from the skin. They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. The first two together along with a number of less common skin cancers are known as nonmelanoma skin cancer (NMSC). Basal-cell cancer grows slowly and can damage the tissue around it but is unlikely to spread to distant areas or result in death. It often appears as a painless raised area of skin, that may be shiny with small blood vessel running over it or may present as a raised area with an ulcer. Squamous-cell cancer is more likely to spread. It usually presents as a hard lump with a scaly top but may also form an ulcer. Melanomas are the most aggressive. Signs include a mole that has changed in size, shape, color, has irregular edges, has more than one color, is itchy or bleeds.
Greater than 90% of cases are caused by exposure to ultraviolet radiation from the Sun. This exposure increases the risk of all three main types of skin cancer. Exposure has increased partly due to a thinner ozone layer. Tanning beds are becoming another common source of ultraviolet radiation. For melanomas and basal-cell cancers exposure during childhood is particularly harmful. For squamous-cell cancers total exposure, irrespective of when it occurs, is more important. Between 20% and 30% of melanomas develop from moles. People with light skin are at higher risk as are those with poor immune function such as from medications or HIV/AIDS. Diagnosis is by biopsy.
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing melanoma and squamous-cell cancer. It is not clear if sunscreen affects the risk of basal-cell cancer. Nonmelanoma skin cancer is usually curable. Treatment is generally by surgical removal but may less commonly involve radiation therapy or topical medications such as fluorouracil. Treatment of melanoma may involve some combination of surgery, chemotherapy, radiation therapy, and targeted therapy. In those people whose disease has spread to other areas of their bodies, palliative care may be used to improve quality of life. Melanoma has one of the higher survival rates among cancers, with over 86% of people in the UK and more than 90% in the United States surviving more than 5 years.
Skin cancer is the most common form of cancer, globally accounting for at least 40% of cases. It is especially common among people with light skin. The most common type is nonmelanoma skin cancer, which occurs in at least 2-3 million people per year. This is a rough estimate, however, as good statistics are not kept. Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell cancers. Basal-cell and squamous-cell cancers rarely result in death. In the United States they were the cause of less than 0.1% of all cancer deaths. Globally in 2012 melanoma occurred in 232,000 people, and resulted in 55,000 deaths. Australia and New Zealand have the highest rates of melanoma in the world. The three main types of skin cancer have become more common in the last 20 to 40 years, especially in those areas which are mostly Caucasian., A single-elimination tournamentalso called an Olympic system tournament, a knockout (or, knock-out), single penetration, or sudden death tournamentis a type of elimination tournament where the loser of each bracket is immediately eliminated from winning the championship or first prize in the event., Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. If left untreated, this growth can spread beyond the lung by the process of metastasis into nearby tissue or other parts of the body. Most cancers that start in the lung, known as primary lung cancers, are carcinomas. The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). The most common symptoms are coughing (including coughing up blood), weight loss, shortness of breath, and chest pains.
The vast majority (85%) of cases of lung cancer are due to long-term tobacco smoking. About 1015% of cases occur in people who have never smoked. These cases are often caused by a combination of genetic factors and exposure to radon gas, asbestos, second-hand smoke, or other forms of air pollution. Lung cancer may be seen on chest radiographs and computed tomography (CT) scans. The diagnosis is confirmed by biopsy which is usually performed by bronchoscopy or CT-guidance.
Prevention is by avoiding risk factors including smoking and air pollution. Treatment and long-term outcomes depend on the type of cancer, the stage (degree of spread), and the person's overall health. Most cases are not curable. Common treatments include surgery, chemotherapy, and radiotherapy. NSCLC is sometimes treated with surgery, whereas SCLC usually responds better to chemotherapy and radiotherapy.
Worldwide in 2012, lung cancer occurred in 1.8 million people and resulted in 1.6 million deaths. This makes it the most common cause of cancer-related death in men and second most common in women after breast cancer. The most common age at diagnosis is 70 years. Overall, 17.4% of people in the United States diagnosed with lung cancer survive five years after the diagnosis, while outcomes on average are worse in the developing world.
Signs and symptoms.
Signs and symptoms which may suggest lung cancer include:, Patrick Joseph Kelly II ( October 29 , 1965 - March 28 , 2003 ) was a National Football League tight end who played for the Denver Broncos ( 1988 -- 1989 ) and the New York Jets ( 1990 -- 1991 ) . He played in 44 games over 4 seasons , starting only the 1988 AFC Championship due to an injury to starter Clarence Kay . Kelly also played in Super Bowl XXIV . He died of cancer on March 28 , 2003 ., Patrick Dennis Bowlen (born February 18, 1944) is the majority owner of the Denver Broncos of the National Football League (NFL). The Bowlen Family, including his two brothers John Bowlen and Bill Bowlen, and sister Marybeth Bowlen, purchased the team from Edgar Kaiser in 1984. He served as the Broncos CEO from his purchase of the club in 1984 until July 2014, when he stepped down as Broncos' CEO due to the onset and progression of Alzheimer's disease., Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.
Risk factors for developing breast cancer include being female, obesity, lack of physical exercise, drinking alcohol, hormone replacement therapy during menopause, ionizing radiation, early age at first menstruation, having children late or not at all, older age, and family history. About 510% of cases are due to genes inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply the ducts with milk. Cancers developing from the ducts are known as ductal carcinomas, while those developing from lobules are known as lobular carcinomas. In addition, there are more than 18 other sub-types of breast cancer. Some cancers, such as ductal carcinoma in situ, develop from pre-invasive lesions. The diagnosis of breast cancer is confirmed by taking a biopsy of the concerning lump. Once the diagnosis is made, further tests are done to determine if the cancer has spread beyond the breast and which treatments it may respond to.
The balance of benefits versus harms of breast cancer screening is controversial. A 2013 Cochrane review stated that it is unclear if mammographic screening does more good or harm. A 2009 review for the US Preventive Services Task Force found evidence of benefit in those 40 to 70 years of age, and the organization recommends screening every two years in women 50 to 74 years old. The medications tamoxifen or raloxifene may be used in an effort to prevent breast cancer in those who are at high risk of developing it. Surgical removal of both breasts is another preventative measure in some high risk women. In those who have been diagnosed with cancer, a number of treatments may be used, including surgery, radiation therapy, chemotherapy, hormonal therapy and targeted therapy. Types of surgery vary from breast-conserving surgery to mastectomy. Breast reconstruction may take place at the time of surgery or at a later date. In those in whom the cancer has spread to other parts of the body, treatments are mostly aimed at improving quality of life and comfort.
Outcomes for breast cancer vary depending on the cancer type, extent of disease, and person's age. Survival rates in the developed world are high, with between 80% and 90% of those in England and the United States alive for at least 5 years. In developing countries survival rates are poorer. Worldwide, breast cancer is the leading type of cancer in women, accounting for 25% of all cases. In 2012 it resulted in 1.68 million cases and 522,000 deaths. It is more common in developed countries and is more than 100 times more common in women than in men., Prostate cancer, also known as carcinoma of the prostate, is the development of cancer in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, some grow relatively quickly. The cancer cells may spread from the prostate to other parts of the body, particularly the bones and lymph nodes. It may initially cause no symptoms. In later stages it can lead to difficulty urinating, blood in the urine, or pain in the pelvis, back or when urinating. A disease known as benign prostatic hyperplasia may produce similar symptoms. Other late symptoms may include feeling tired due to low levels of red blood cells.
Factors that increase the risk of prostate cancer include: older age, a family history of the disease, and race. About 99% of cases occur in those over the age of 50. Having a first-degree relative with the disease increases the risk two to threefold. In the United States it is more common in the African American population than the white American population. Other factors that may be involved include a diet high in processed meat, red meat, or milk products or low in certain vegetables. An association with gonorrhea has been found, but a reason for this relationship has not been identified. Prostate cancer is diagnosed by biopsy. Medical imaging may then be done to determine if the cancer has spread to other parts of the body.
Prostate cancer screening is controversial. Prostate-specific antigen (PSA) testing increases cancer detection but does not decrease mortality. The United States Preventive Services Task Force recommends against screening using the PSA test, due to the risk of overdiagnosis and overtreatment, as most cancer diagnosed would remain asymptomatic. The USPSTF concludes that the potential benefits of testing do not outweigh the expected harms. While 5-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention. Supplementation with vitamins or minerals does not appear to affect the risk.
Many cases can be safely followed with active surveillance or watchful waiting. Other treatments may include a combination of surgery, radiation therapy, hormone therapy or chemotherapy. When it only occurs inside the prostate it may be curable. In those in whom the disease has spread to the bones, pain medications, bisphosphonates and targeted therapy, among others, may be useful. Outcomes depend on a person's age and other health problems as well as how aggressive and extensive the cancer is. Most people with prostate cancer do not end up dying from the disease. The 5-year survival rate in the United States is 99%. Globally it is the second most common type of cancer and the fifth leading cause of cancer-related death in men. In 2012 it occurred in 1.1 million men and caused 307,000 deaths. It was the most common cancer in males in 84 countries, occurring more commonly in the developed world. Rates have been increasing in the developing world. Detection increased significantly in the 1980s and 1990s in many areas due to increased PSA testing. Studies of males who died from unrelated causes have found prostate cancer in 30% to 70% of those over age 60.
Signs and symptoms.
Early prostate cancer usually has no clear symptoms. Sometimes, however, prostate cancer does cause symptoms, often similar to those of diseases such as benign prostatic hyperplasia. These include frequent urination, nocturia (increased urination at night), difficulty starting and maintaining a steady stream of urine, hematuria (blood in the urine), and dysuria (painful urination). A study based on the 1998 Patient Care Evaluation in the US found that about a third of patients diagnosed with prostate cancer had one or more such symptoms, while two-thirds had no symptoms., Subject: pat kelly , Relation: cause_of_death, Options: (A) brain tumor (B) breast cancer (C) cancer (D) carcinoma (E) cervical cancer (F) club (G) consumption (H) disease (I) fall (J) fever (K) heart disease (L) hepatitis (M) hepatitis c (N) illness (O) infection (P) influenza (Q) injury (R) jaundice (S) leukemia (T) liver cancer (U) lymphoma (V) measles (W) melanoma (X) multiple myeloma (Y) skin cancer (Z) smallpox ([) tournament (\) tumor
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