Information:  - In urologic pathology , PUNLMP , short for papillary urothelial neoplasm of low malignant potential , is an exophytic ( outward growing ) , ( microscopically ) nipple - shaped ( or papillary ) pre-malignant growth of the lining of the upper genitourinary tract ( the urothelium ) , which includes the renal pelvis , ureters , urinary bladder and part of the urethra . PUNLMP is pronounced pun - lump , like the words pun and lump . As their name suggests , PUNLMPs are neoplasms , i.e. clonal cellular proliferations , that are thought to have a low probability of developing into urothelial cancer , i.e. a malignancy such as bladder cancer . They are thought to be relatively rare ; one study of two - hundred papillary urothelial lesions found a prevalence of 0 - 3.5 % .  - A penis (plural "penises" or "penes" ) is the primary sexual organ that male animals use to inseminate sexually receptive mates (usually females and hermaphrodites respectively) during copulation. Such organs occur in many animals, both vertebrate and invertebrate, but males do not bear a penis in every animal species, and in those species in which the male does bear a so-called penis, the penes in the various species are not necessarily homologous. For example, the penis of a mammal is at most analogous to the penis of a male insect or barnacle.  - Anatomy is the branch of biology concerned with the study of the structure of organisms and their parts. Anatomy is inherently tied to embryology, comparative anatomy, evolutionary biology, and phylogeny, as these are the processes by which anatomy is generated over immediate (embryology) and long (evolution) timescales. Human anatomy is one of the basic essential sciences of medicine.  - In anatomy, the urethra (from Greek   "ourthr") is a tube that connects the urinary bladder to the urinary meatus for the removal of fluids from the body. In male placental mammals, the urethra travels through the penis, and carries semen as well as urine. In female placental mammals, the urethra is shorter and emerges at the female external urethral orifice above the vaginal opening.  - Semen, also known as seminal fluid, is an organic fluid that may contain spermatozoa. It is secreted by the gonads (sexual glands) and other sexual organs of male or hermaphroditic animals and can fertilize female ova. In humans, seminal fluid contains several components besides spermatozoa: proteolytic and other enzymes as well as fructose are elements of seminal fluid which promote the survival of spermatozoa, and provide a medium through which they can move or "swim".  - The urinary bladder is a hollow muscular organ that collects urine from the kidneys before disposal by urination. A hollow muscular, and distensible (or elastic) organ, the bladder sits on the pelvic floor. Urine enters the bladder via the ureters and exits via the urethra. The typical human bladder capacity is between 300 and (10.14 and ).  - Neoplasm is an abnormal growth of tissue, and, when it also forms a mass, is commonly referred to as a tumor. This abnormal growth (neoplasia) usually but not always forms a mass.  - The renal pelvis or pelvis of the kidney is the basin-like or funnel-like dilated proximal part of the ureter in the kidney.  - The kidneys are two bean-shaped organs found on the left and right sides of the body in vertebrates. They filter the blood in order to make urine, to release and retain water, and to remove waste. They also control the ion concentrations and acid-base balance of the blood. Each kidney feeds urine into the bladder by means of a tube known as the ureter.  - Diagnosis is the identification of the nature and cause of a certain phenomenon. Diagnosis is used in many different disciplines with variations in the use of logic, analytics, and experience to determine "cause and effect". In systems engineering and computer science, it is typically used to determine the causes of symptoms, mitigations, and solutions.  - Medicine (British English ; American English ) is the science and practice of the diagnosis, treatment, and prevention of disease. The word "medicine" is derived from Latin "medicus", meaning "a physician". Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.  - Urothelium (or uroepithelium) is an example of "transitional epithelium". It is the type of epithelium that lines much of the urinary tract including the renal pelvis, the ureters, the bladder, and parts of the urethra.   - A disease is a particular abnormal condition, a disorder of a structure or function, that affects part or all of an organism. The study of disease is called pathology which includes the causal study of etiology. Disease is often construed as a medical condition associated with specific symptoms and signs. It may be caused by external factors such as pathogens, or it may be caused by internal dysfunctions particularly of the immune system such as an immunodeficiency, or a hypersensitivity including allergies and autoimmunity.  - In human anatomy, the ureters are tubes made of smooth muscle fibers that propel urine from the kidneys to the urinary bladder. In the adult, the ureters are usually long and ~34 mm in diameter. Histologically, the ureter contains transitional epithelium and an additional smooth muscle layer in the more distal one-third to assist with peristalsis.  - The urinary meatus, also known as the external urethral orifice, is the opening or meatus of the urethra. It is the point where urine exits the urethra in males and in females, and also where semen exits the urethra in males. The meatus has varying degrees of sensitivity to touch. The meatus is located on the glans penis in males and in the vulval vestibule in females.  - The pelvic floor or pelvic diaphragm is composed of muscle fibers of the levator ani, the coccygeus muscle, and associated connective tissue which span the area underneath the pelvis. The pelvic diaphragm is a muscular partition formed by the levatores ani and coccygei, with which may be included the parietal pelvic fascia on their upper and lower aspects. The pelvic floor separates the pelvic cavity above from the perineal region (including perineum) below.  - Transitional epithelium is a type of tissue consisting of multiple layers of epithelial cells which can contract and expand. It is so named because of this function in the transition of degree of distension. This tissue structure type is found in urothelium, including that of the renal pelvis, urinary bladder, the ureters, the superior urethra, and the prostatic and ejaculatory ducts of the prostate.  - Urination is the release of urine from the urinary bladder through the urethra to the outside of the body. It is the urinary system's form of excretion. It is also known medically as micturition, voiding, uresis, or, rarely, emiction, and known colloquially by various names including tinkling, peeing, weeing, whizzing, pissing, and draining the snake.  - Epithelium ("epi-" + "thele" + "-ium") is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. Epithelial tissues line the cavities and surfaces of blood vessels and organs throughout the body.  - A funnel is a pipe with a wide (often conical) mouth and a narrow stem. It is used to channel liquid or fine-grained substances into containers with a small opening. Without a funnel, spillage may occur.  - Urine is a liquid by-product of metabolism in the bodies of many animals, including humans. It is expelled from the kidneys and flows through the ureters to the urinary bladder, from which it is soon excreted from the body through the urethra during urination.  - Pathology (from the Greek roots of "pathos", meaning "experience" or "suffering", and "-logia", "study of") is a significant component of the causal study of disease and a major field in modern medicine and diagnosis.  - In mammals, the vagina is a muscular and tubular part of the female genital tract, which in humans extends from the vulva to the cervix. The outer vaginal opening may be partly covered by a membrane called the hymen. At the deep end, the cervix (neck of the uterus) bulges into the vagina. The vagina allows for sexual intercourse and childbirth, and channels menstrual flow, which occurs periodically as part of the menstrual cycle.    After reading the paragraphs above, we are interested in knowing the entity with which 'papillary urothelial neoplasm of low malignant potential' exhibits the relationship of 'instance of'. Find the answer from the choices below.  Choices: - adult  - anatomy  - animal  - area  - bear  - branch  - cause  - channel  - component  - disease  - filter  - fluid  - four  - function  - health  - human  - humans  - injury  - ion  - ionizing radiation  - line  - liquid  - logic  - mass  - may  - medicine  - membrane  - metabolism  - muscle  - neoplasm  - opening  - organ  - part  - penis  - penises  - phenomenon  - pipe  - point  - practice  - product  - release  - research  - science  - species  - study  - system  - tissue  - tract  - two  - word
The answer to this question is:
disease