Please answer this: Information:  - A game engine is a software framework designed for the creation and development of video games. Developers use them to create games for consoles, mobile devices and personal computers. The core functionality typically provided by a game engine includes a rendering engine (renderer) for 2D or 3D graphics, a physics engine or collision detection (and collision response), sound, scripting, animation, artificial intelligence, networking, streaming, memory management, threading, localization support, scene graph, and may include video support for cinematics. The process of game development is often economized, in large part, by reusing/adapting the same game engine to create different games, or to make it easier to "port" games to multiple platforms.  - Fox Interactive was a video game publisher and developer mainly concerned with titles based on 20th Century Fox properties, such as "The Simpsons", "Family Guy", "Futurama", the "Alien" and "Predator 2", and "" , "Predator" film franchises, "Independence Day", "Charmed", "Buffy the Vampire Slayer", "The X-Files", "24", the first two "Ice Age" films, the "Die Hard" series of films and others made by 20th Century Fox. They have also been involved with original titles, including "".  - A video game is an electronic game that involves human or animal interaction with a user interface to generate visual feedback on a video device such as a TV screen or computer monitor. The word "video" in "video game" traditionally referred to a raster display device, but as of the 2000s, it implies any type of display device that can produce two- or three-dimensional images. Some theorists categorize video games as an art form, but this designation is controversial.  - LithTech is a game engine which was initially developed by Monolith Productions in collaboration with Microsoft. Monolith later formed a separate company, LithTech Inc., to deal with further advancements of the engine technology and currently, after a change of its corporate identity, LithTech Inc. is known as Touchdown Entertainment.  - Monolith Productions (or simply Monolith) is a Kirkland, Washington-based Video game developer founded in October 1994 by Brian Goble, Garrett Price, Paul Renault, Toby Gladwell, Brian Waite and Jace Hall.The Company is known for their games "Blood", the "No One Lives Forever" series, "F.E.A.R" and more recently, "". Monolith is also known for the development of the graphical game engine LithTech, which has been used for most of their games and premièred with "" in September 1998; they also used Brian Goble's Windows Animation Package 32 engine for their 2D games. Between 1997 and 1999, Monolith also published games, some developed by the studio, some by third parties.  - Sanity : Aiken 's Artifact is a 2000 action video game developed by Monolith Productions and published by Fox Interactive . The game 's lead character , Agent Nathaniel Cain , was voiced by Ice - T.    What is the relationship between 'sanity: aiken's artifact' and 'lithtech'?
++++++++
Answer: software engine


Q: Information:  - The National Institutes of Health (NIH) is a biomedical research facility primarily located in Bethesda, Maryland. An agency of the United States Department of Health and Human Services, it is the primary agency of the United States government responsible for biomedical and health-related research. The NIH both conducts its own scientific research through its Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program.  - PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintains the database as part of the Entrez system of information retrieval.  - MEDLINE (Medical Literature Analysis and Retrieval System Online, or MEDLARS Online) is a bibliographic database of life sciences and biomedical information. It includes bibliographic information for articles from academic journals covering medicine, nursing, pharmacy, dentistry, veterinary medicine, and health care. MEDLINE also covers much of the literature in biology and biochemistry, as well as fields such as molecular evolution.  - HubMed is an alternative , third - party interface to PubMed , the database of biomedical literature produced by the National Library of Medicine . Features include relevance - ranked search results , direct citation export , tagging and graphical display of related articles .  - The Entrez Global Query Cross-Database Search System is a federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website. The NCBI is a part of the National Library of Medicine (NLM), which is itself a department of the National Institutes of Health (NIH), which in turn is a part of the United States Department of Health and Human Services. The name "Entrez" (a greeting meaning "Come in!" in French) was chosen to reflect the spirit of welcoming the public to search the content available from the NLM.  - Information retrieval (IR) is the activity of obtaining information resources relevant to an information need from a collection of information resources. Searches can be based on full-text or other content-based indexing.  - The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library.    What is the relationship between 'hubmed' and 'website'?
A:
instance of