Information:  - Immunoglobulin M, or IgM for short, is a basic antibody that is produced by B cells. IgM is by far the physically largest antibody in the human circulatory system. It is the first antibody to appear in response to initial exposure to an antigen. The spleen, where plasmablasts responsible for antibody production reside, is the major site of specific IgM production.  - Hyper IgM syndromes is a group of primary immune deficiency disorders characterized by defective CD40 signaling; "via" B cells affecting class switch recombination(CSR) and somatic hypermutation. Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum Immunoglobulin M (IgM) levels and a considerable deficiency in Immunoglobulins G (IgG), A (IgA) and E (IgE). As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections.  - Macrophages (from Greek "" ("makros") = large, "" ("phagein") = to eat) are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, cancer cells, and anything else that does not have the types of proteins specific to healthy body cells on its surface in a process called phagocytosis. These large phagocytes are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system. Besides phagocytosis, they play a critical role in nonspecific defense (innate immunity) and also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes. For example, they are important as antigen presenters to T cells. In humans, dysfunctional macrophages cause severe diseases such as chronic granulomatous disease that result in frequent infections.  - B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system by secreting antibodies. Additionally, B cells present antigen (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines.  - Hyper - IgM syndrome type 3 is a form of Hyper IgM syndrome characterized by mutations of the CD40 gene . In this type , Immature B cells can not receive signal 2 from helper T cells which is necessary to mature into mature B cells .  - IGE (Internet Gaming Entertainment) is a company which trades in virtual currency and accounts for MMORPGs. One of the main dealers in virtual economy services, members of the gaming community were often critical of IGE, as its services may allow players to break rules in online games.  - In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the "CD4" gene.    Given the information above, choose from the list below the object entity that exhibits the relation 'instance of' with the subject 'hyper-igm syndrome type 3'.  Choices: - antibody  - blood cell  - cell  - class  - community  - component  - disease  - economy  - entertainment  - function  - group  - internet  - professional  - subtype  - system
disease

Information:  - A firefighter (historically fireman) is a rescuer extensively trained in firefighting, primarily to extinguish hazardous fires that threaten property and civilian or natural populations, and to rescue people from dangerous situations, like collapsed or burning buildings or crashed vehicles. In some areas, they are also trained in Emergency Medical Services (EMS) and operate ambulances in addition to being a firefighter.  - A fire hydrant is an active fire protection measure , and a connection point by which firefighters can tap into a water supply .  - Active fire protection (AFP) is an integral part of fire protection. AFP is characterized by items and/or systems, which require a certain amount of motion and response in order to work, contrary to passive fire protection.  - Fire protection is the study and practice of mitigating the unwanted effects of potentially destructive fires. It involves the study of the behaviour, compartmentalisation, suppression and investigation of fire and its related emergencies, as well as the research and development, production, testing and application of mitigating systems. In structures, be they land-based, offshore or even ships, the owners and operators are responsible to maintain their facilities in accordance with a design-basis that is rooted in laws, including the local building code and fire code, which are enforced by the Authority Having Jurisdiction.    Given the information above, choose from the list below the object entity that exhibits the relation 'use' with the subject 'fire hydrant'.  Choices: - firefighting  - passive fire protection  - production  - research and development
firefighting