Point signature, a representation describing the structural neighborhood of a point in 3D shapes, can be applied to establish correspondences between points in 3D shapes. Conventional methods apply a weight-sharing network, e.g., any kind of graph neural networks, across all neighborhoods to directly generate point signatures and gain the generalization ability by extensive training over a large amount of training samples from scratch. However, these methods lack the flexibility in rapidly adapting to unseen neighborhood structures and thus generalizes poorly on new point sets. In this paper, we propose a novel meta-learning based 3D point signature model, named 3Dmetapointsignature (MEPS) network, that is capable of learning robust point signatures in 3D shapes. By regarding each point signature learning process as a task, our method obtains an optimized model over the best performance on the distribution of all tasks, generating reliable signatures for new tasks, i.e., signatures of unseen point neighborhoods. Specifically, the MEPS consists of two modules: a base signature learner and a meta signature learner. During training, the base-learner is trained to perform specific signature learning tasks. In the meantime, the meta-learner is trained to update the base-learner with optimal parameters. During testing, the meta-learner that is learned with the distribution of all tasks can adaptively change parameters of the base-learner, accommodating to unseen local neighborhoods. We evaluate the MEPS model on two datasets, e.g., FAUST and TOSCA, for dense 3Dshape correspondence. Experimental results demonstrate that our method not only gains significant improvements over the baseline model and achieves state-of-the-art results, but also is capable of handling unseen 3D shapes.