An efficient and robust approach to Mendelian randomization with measured pleiotropic effects in a high-dimensional setting

1 Nov 2019Andrew J. GrantStephen Burgess

Valid estimation of a causal effect using instrumental variables requires that all of the instruments are independent of the outcome conditional on the risk factor of interest and any confounders. In Mendelian randomization studies with large numbers of genetic variants used as instruments, it is unlikely that this condition will be met... (read more)

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