In this paper, an orthogonal stochastic gradient descent (O-SGD) based learning approach is proposed to tackle the wireless channel over-training problem inherent in artificial neural network (ANN)-assisted MIMO signal detection. Our basic idea lies in the discovery and exploitation of the training-sample orthogonality between the current training epoch and past training epochs... Unlike the conventional SGD that updates the neural network simply based upon current training samples, O-SGD discovers the correlation between current training samples and historical training data, and then updates the neural network with those uncorrelated components. The network updating occurs only in those identified null subspaces. By such means, the neural network can understand and memorize uncorrelated components between different wireless channels, and thus is more robust to wireless channel variations. This hypothesis is confirmed through our extensive computer simulations as well as performance comparison with the conventional SGD approach. (read more)