Efficient quantitative hyperspectral image unmixing method for large-scale Raman micro-spectroscopy data analysis

5 Mar 2018E. G. LobanovaS. V. Lobanov

Vibrational micro-spectroscopy is a powerful optical tool, providing a non-invasive label-free chemically specific imaging for many chemical and biomedical applications. However, hyperspectral image produced by Raman micro-spectroscopy typically consists of thousands discrete pixel points, each having individual Raman spectrum at thousand wavenumbers, and therefore requires appropriate image unmixing computational methods to retrieve non-negative spatial concentration and corresponding non-negative spectra of the image biochemical constituents... (read more)

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