Existence and incompressible limit of a tissue growth model with autophagy

7 Feb 2021  ·  Jian-Guo Liu, Xiangsheng Xu ·

In this paper we study a cross-diffusion system whose coefficient matrix is non-symmetric and degenerate. The system arises in the study of tissue growth with autophagy. The existence of a weak solution is established. We also investigate the limiting behavior of solutions as the pressure gets stiff. The so-called incompressible limit is a free boundary problem of Hele-Shaw type. Our key new discovery is that the usual energy estimate still holds as long as the time variable stays away from $0$.

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Analysis of PDEs