Joint Analysis of Individual-level and Summary-level GWAS Data by Leveraging Pleiotropy

30 Apr 2018 Dai Mingwei Wan Xiang Peng Hao Wang Yao Liu Yue Liu Jin Xu Zongben Yang Can

A large number of recent genome-wide association studies (GWASs) for complex phenotypes confirm the early conjecture for polygenicity, suggesting the presence of large number of variants with only tiny or moderate effects. However, due to the limited sample size of a single GWAS, many associated genetic variants are too weak to achieve the genome-wide significance... (read more)

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