Microvascular Dynamics from 4D Microscopy Using Temporal Segmentation

14 Jan 2020Shir GurLior WolfLior GolgherPablo Blinder

Recently developed methods for rapid continuous volumetric two-photon microscopy facilitate the observation of neuronal activity in hundreds of individual neurons and changes in blood flow in adjacent blood vessels across a large volume of living brain at unprecedented spatio-temporal resolution. However, the high imaging rate necessitates fully automated image analysis, whereas tissue turbidity and photo-toxicity limitations lead to extremely sparse and noisy imagery... (read more)

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