miR-34a-5p and miR-34a-3p contribute to the signaling pathway of p53 by targeting overlapping sets of genes

10 Aug 2016 Chafik Abderrahim

In contrary to the common belief that only one strand of the pre-miRNA is active (usually the 5p one that is the more abundant) while the second one (miRNA*) is discarded, functional 5p and 3p have been observed for many miRNAs. Among those miRNAs is miR-34a which is a target gene of the tumor suppressor p53... (read more)

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