Modulation of synaptic plasticity by glutamatergic gliotransmission: A modeling study

12 Aug 2016 De Pittà Maurizio Brunel Nicolas

Glutamatergic gliotransmission, that is the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. Here, we focus on two experimentally well-identified gliotransmitter patwhays: (i)~modulations of synaptic release and (ii)~postynaptic slow inward currents mediated by glutamate released from astrocytes, and investigate their possible functional relevance on synaptic plasticity in a biophysical model of an astrocyte-regulated synapse... (read more)

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