Reconstructing continuous distributions of 3D protein structure from cryo-EM images

ICLR 2020 Ellen D. ZhongTristan BeplerJoseph H. DavisBonnie Berger

Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of proteins and other macromolecular complexes at near-atomic resolution. In single particle cryo-EM, the central problem is to reconstruct the three-dimensional structure of a macromolecule from $10^{4-7}$ noisy and randomly oriented two-dimensional projections... (read more)

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