Reducing complexity and unidentifiability when modelling human atrial cells

29 Jan 2020 C. Houston B. Marchand L. Engelbert C. D. Cantwell

Mathematical models of a cellular action potential in cardiac modelling have become increasingly complex, particularly in gating kinetics which control the opening and closing of individual ion channel currents. As cardiac models advance towards use in personalised medicine to inform clinical decision-making, it is critical to understand the uncertainty hidden in parameter estimates from their calibration to experimental data... (read more)

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